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Presence Current · Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-08-20
Joshua L. Kennedy profile photo

Joshua L. Kennedy

High Impact

Associate Professor

Also affiliated: Carter Center (2013); Arkansas Children's Hospital (2009–2025); University of New Mexico (2018); University of Arkansas Medical Center (2017–2025); University of Virginia Health System (2012–2014); ENT and Allergy (2014); Central Middlesex Hospital (1982); Arkansas Children's Nutrition Center (2018–2023); Arkansas Department of Agriculture (2008–2017); University of Virginia (2011–2022); Syracuse University (2014); University of the West of Scotland (2022–2023)

Faculty Researcher

Peds Pediatrics, College of Medicine

25 h-index 141 pubs 2,263 cited

  • Humans
  • Asthma
  • Female
  • Male
  • COVID-19
  • Rhinovirus
  • Child
  • Picornaviridae Infections
  • Adult
  • SARS-CoV-2
  • Animals
  • Adolescent
  • Immunoglobulin E
  • Child, Preschool
  • Virus Diseases

Biography and Research Information

OverviewAI-generated summary

Joshua L. Kennedy's research focuses on the mechanisms by which rhinovirus (RV) infection exacerbates asthma, particularly in children. He investigates the synergistic interaction between RV infection and allergen sensitization, which significantly increases the likelihood of wheezing in children treated in emergency departments. His work examines epithelial cell-derived cytokines, such as IL-33, IL-25, and TSLP, that contribute to a Th2-biased allergic response during RV infections.

Research Overview

Dr. Kennedy received his medical degree from UAMS in 2006 and completed an Internal Medicine and Pediatrics residency from 2006 to 2010. He went on to complete a fellowship in Allergy and Immunology at the University of Virginia. Dr. Kennedy joined the faculty of UAMS in July 2013 where he is a member of the Division of Pediatric Allergy and Immunology and the ACRI Lung Cell Biology Lab. Dr. Kennedy’s primary research focuses upon mechanisms whereby infection with the common cold virus, rhinovirus (RV), leads to exacerbations of asthma. 60% to 80% of children seen in the emergency room with an exacerbation of asthma will be infected with RV. In his previous research, it became clear that while RV infection alone increases the risk of wheezing in children with asthma; the combination of RV infection and high titer sensitization to allergen significantly increases the odds to wheeze in children seen in the emergency department. It is this synergy between allergy and RV infection that drives his current research hypotheses. To that end, he is studying epithelial cell-derived cytokines that bias a Th2 (i.e., allergic) response (IL-33, IL-25, and TSLP) associated with RV infection in subjects with asthma both in vitro and in vivo. Also, Dr. Kennedy enthusiastically contributes to the education of fellows, residents, and students at UAMS by participating in the educational mission of the Department of Pediatrics in many capacities.

Metrics

  • h-index: 25
  • Publications: 141
  • Citations: 2,263

Selected Publications

  • Alarmins Modulate Airway Contraction and Relaxation of Human Small Airways (2026)
  • Implementation of early peanut introduction among providers in a southern US state (2026)
    Journal of Allergy and Clinical Immunology Global DOI OpenAlex
  • Assessing Strategies to Increase Combination Inhaler Use for Asthma Rescue: A Multi-Phase Quality Improvement Project (2026)
    Journal of Allergy and Clinical Immunology DOI OpenAlex
  • Hospitalizations and Severity of Rhinovirus-Associated Asthma Exacerbations in Children During the Institution of Non-pharmaceutical Interventions (2026)
    Journal of Allergy and Clinical Immunology DOI OpenAlex
  • Evaluating Oral Food Challenge Outcomes to the "Big 9” Allergens (2026)
    Journal of Allergy and Clinical Immunology DOI OpenAlex
  • Exploring new frontiers in eosinophilic chronic rhinosinusitis (2025)
    Annals of Allergy Asthma & Immunology DOI OpenAlex
  • From lockdown to recovery: changing patterns of viral infection severity in a pediatric cohort with asthma (2025)
    Frontiers in Allergy DOI OpenAlex
  • Beyond respiratory syncytial virus and rhinovirus (2025)
    Annals of Allergy Asthma & Immunology 2 citations DOI OpenAlex
  • Prevalence of Adverse Drug Reactions: Comparing Crotalidae Immune Polyvalent Antivenoms F(ab’)2 and F(ab) in a Galactose-alpha-1,3-galactose (alpha-gal) Endemic Area (2025)
    Annals of Emergency Medicine 5 citations DOI OpenAlex
  • Asthma Associated Cytokines Regulate Gasdermin A and Gasdermin B Expression by Human Bronchial Epithelial Cells (2025)
    Clinical & Experimental Allergy 2 citations DOI OpenAlex
  • Resurgence of Respiratory Syncytial Virus Following COVID-19 Pandemic Measures: A Study of Antibody Dynamics in Young Children (2025)
    Journal of Allergy and Clinical Immunology DOI OpenAlex
  • IL-1β-driven NF-κB transcription of ACE2 as a Mechanism of Macrophage Infection by SARS-CoV-2 (2024)
    bioRxiv (Cold Spring Harbor Laboratory) 1 citation DOI OpenAlex
  • Rare inborn error of immunity presenting as acute respiratory failure (2024)
    Journal of Paediatrics and Child Health DOI OpenAlex
  • Younger and rural children are more likely to be hospitalized for SARS-CoV-2 infections (2024)
    PLoS ONE 3 citations DOI OpenAlex
  • Linking <i>The Cancer Imaging Archive</i> and <scp>GenBank</scp> to the <scp>National Clinical Cohort Collaborative</scp> (2024)
    Learning Health Systems DOI OpenAlex

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Federal Grants 1 $756,000 total

NIH Co-PI Jul 2024 - Jun 2029

CTSA K12 Program at the University of Arkansas for Medical Sciences

National Center for Advancing Translational Sciences $756,000 K12

Grants & Funding

As listed on this researcher's institutional profile. Federal awards with verified records are shown above.

  • “Host-Pathogen Genomic Determinants of Pediatric Respiratory Infection Severity.” CTSA TRI Western Consortium Principal Investigator
  • “Examining the intersection of rhinovirus infection and asthma exacerbations.” ACRI Marion B Lyon New Scientist Development Award Principal Investigator
  • Kennedy Recruitment ACHRI (ACHRI # 033068) UAMS ACHRI Flow Through Principal Investigator
  • DISCOVAR:Disparities in Immune Response to SARS-CoV-2 in ARkansas NIH Co-Investigator
  • An Integrated Host-Microbe Gene Classifier to Predict SARS-CoV-2 and Severe Disease in Children with Respiratory Viral Coinfections NIH Principal Investigator
  • “Examining mechanisms of synergy between asthma exacerbations and RV infection.” NIH NIAID Principal Investigator
  • Enhancing SARS-CoV-2 Sequencing Efforts for Variants in AR UAMS ACHRI Flow Through Principal Investigator
  • ORMDL3 Stimulated ICAM1 and RVA-induced Childhood Asthma Exacerbations NIH Principal Investigator

Collaboration Network

245 Collaborators 59 Institutions 6 Countries

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