Joshua L. Kennedy
Associate Professor
Also affiliated: Carter Center (2013); Arkansas Children's Hospital (2009–2025); University of New Mexico (2018); University of Arkansas Medical Center (2017–2025); University of Virginia Health System (2012–2014); ENT and Allergy (2014); Central Middlesex Hospital (1982); Arkansas Children's Nutrition Center (2018–2023); Arkansas Department of Agriculture (2008–2017); University of Virginia (2011–2022); Syracuse University (2014); University of the West of Scotland (2022–2023)
Faculty Researcher
Peds Pediatrics, College of Medicine
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Joshua L. Kennedy's research focuses on the mechanisms by which rhinovirus (RV) infection exacerbates asthma, particularly in children. He investigates the synergistic interaction between RV infection and allergen sensitization, which significantly increases the likelihood of wheezing in children treated in emergency departments. His work examines epithelial cell-derived cytokines, such as IL-33, IL-25, and TSLP, that contribute to a Th2-biased allergic response during RV infections.
Research Overview
Dr. Kennedy received his medical degree from UAMS in 2006 and completed an Internal Medicine and Pediatrics residency from 2006 to 2010. He went on to complete a fellowship in Allergy and Immunology at the University of Virginia. Dr. Kennedy joined the faculty of UAMS in July 2013 where he is a member of the Division of Pediatric Allergy and Immunology and the ACRI Lung Cell Biology Lab. Dr. Kennedy’s primary research focuses upon mechanisms whereby infection with the common cold virus, rhinovirus (RV), leads to exacerbations of asthma. 60% to 80% of children seen in the emergency room with an exacerbation of asthma will be infected with RV. In his previous research, it became clear that while RV infection alone increases the risk of wheezing in children with asthma; the combination of RV infection and high titer sensitization to allergen significantly increases the odds to wheeze in children seen in the emergency department. It is this synergy between allergy and RV infection that drives his current research hypotheses. To that end, he is studying epithelial cell-derived cytokines that bias a Th2 (i.e., allergic) response (IL-33, IL-25, and TSLP) associated with RV infection in subjects with asthma both in vitro and in vivo. Also, Dr. Kennedy enthusiastically contributes to the education of fellows, residents, and students at UAMS by participating in the educational mission of the Department of Pediatrics in many capacities.
Metrics
- h-index: 25
- Publications: 141
- Citations: 2,263
Selected Publications
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Alarmins Modulate Airway Contraction and Relaxation of Human Small Airways (2026)
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Implementation of early peanut introduction among providers in a southern US state (2026)
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Assessing Strategies to Increase Combination Inhaler Use for Asthma Rescue: A Multi-Phase Quality Improvement Project (2026)
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Hospitalizations and Severity of Rhinovirus-Associated Asthma Exacerbations in Children During the Institution of Non-pharmaceutical Interventions (2026)
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Evaluating Oral Food Challenge Outcomes to the "Big 9” Allergens (2026)
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Exploring new frontiers in eosinophilic chronic rhinosinusitis (2025)
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From lockdown to recovery: changing patterns of viral infection severity in a pediatric cohort with asthma (2025)
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Beyond respiratory syncytial virus and rhinovirus (2025)
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Prevalence of Adverse Drug Reactions: Comparing Crotalidae Immune Polyvalent Antivenoms F(ab’)2 and F(ab) in a Galactose-alpha-1,3-galactose (alpha-gal) Endemic Area (2025)
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Asthma Associated Cytokines Regulate Gasdermin A and Gasdermin B Expression by Human Bronchial Epithelial Cells (2025)
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Resurgence of Respiratory Syncytial Virus Following COVID-19 Pandemic Measures: A Study of Antibody Dynamics in Young Children (2025)
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IL-1β-driven NF-κB transcription of ACE2 as a Mechanism of Macrophage Infection by SARS-CoV-2 (2024)
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Rare inborn error of immunity presenting as acute respiratory failure (2024)
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Younger and rural children are more likely to be hospitalized for SARS-CoV-2 infections (2024)
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Linking <i>The Cancer Imaging Archive</i> and <scp>GenBank</scp> to the <scp>National Clinical Cohort Collaborative</scp> (2024)
Federal Grants 1 $756,000 total
CTSA K12 Program at the University of Arkansas for Medical Sciences
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- “Host-Pathogen Genomic Determinants of Pediatric Respiratory Infection Severity.” CTSA TRI Western Consortium Principal Investigator
- “Examining the intersection of rhinovirus infection and asthma exacerbations.” ACRI Marion B Lyon New Scientist Development Award Principal Investigator
- Kennedy Recruitment ACHRI (ACHRI # 033068) UAMS ACHRI Flow Through Principal Investigator
- DISCOVAR:Disparities in Immune Response to SARS-CoV-2 in ARkansas NIH Co-Investigator
- An Integrated Host-Microbe Gene Classifier to Predict SARS-CoV-2 and Severe Disease in Children with Respiratory Viral Coinfections NIH Principal Investigator
- “Examining mechanisms of synergy between asthma exacerbations and RV infection.” NIH NIAID Principal Investigator
- Enhancing SARS-CoV-2 Sequencing Efforts for Variants in AR UAMS ACHRI Flow Through Principal Investigator
- ORMDL3 Stimulated ICAM1 and RVA-induced Childhood Asthma Exacerbations NIH Principal Investigator
- “Mechanisms for Rhinovirus Induced Airway Hyper-responsiveness in Human Lung.” NIGMS COBRE Pilot Project Award Principal Investigator
- Targeting lipid rafts for treatment of asthma NIH Co-Principal Investigator
- ORMDL3 Stimulated ICAM1 and RVA-induced Childhood Asthma Exacerbations NIH/Nat. Inst. of Allergy & Infectious Diseases via UAMS ACHRI Flow Through Principal Investigator
- Host-Pathogen Genomic Determinants of Pediatric Respiratory Infection Severity UAMS Intramural Grant (CTSA) Principal Investigator
- Targeting Lipid Rafts for Treatment of Asthma UAMS ACHRI Flow Through Principal Investigator
- Examining mechanisms of synergy between asthma exacerbations and RV infections UAMS Clinician Scientist Program Principal Investigator
- GR034183-Kennedy-Enhancing SARS-CoV-2 Sequencing Efforts for Variants in the State of Arkansas UAMS ACHRI Flow Through Principal Investigator
- GR034176-Kennedy-ACRI-Airway Inflammation and Airway Remodeling in Severe Asthma-Cont of Dr. Kurten's(Retired) UAMS ACHRI Flow Through Principal Investigator
Collaboration Network
Top Collaborators
- Development of ACE2 autoantibodies after SARS-CoV-2 infection
- The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
Showing 5 of 10 shared publications
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- Implementing Pharmacogenomics Testing: Single Center Experience at Arkansas Children’s Hospital
- SARS-CoV-2 pandemic non-pharmacologic interventions temporally associated with reduced pediatric infections due to <i>Mycoplasma pneumoniae</i> and co-infecting respiratory viruses in Arkansas
- SARS-CoV-2 Infection Mitigation Strategies Concomitantly Reduce Group A Streptococcus Pharyngitis
- Effects of nonpharmaceutical interventions during COVID-19 pandemic on pediatric asthma exacerbations and viral infections
Showing 5 of 10 shared publications
- Development of ACE2 autoantibodies after SARS-CoV-2 infection
- The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
- Modifying laboratory testing via home brew during the COVID-19 pandemic
Showing 5 of 9 shared publications
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- Rural Research Network to engage rural and minority community members in translational research
- State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
- Modifying laboratory testing via home brew during the COVID-19 pandemic
Showing 5 of 8 shared publications
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
- Effects of nonpharmaceutical interventions during COVID-19 pandemic on pediatric asthma exacerbations and viral infections
- Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas
Showing 5 of 8 shared publications
- SARS-CoV-2 pandemic non-pharmacologic interventions temporally associated with reduced pediatric infections due to <i>Mycoplasma pneumoniae</i> and co-infecting respiratory viruses in Arkansas
- Genomic surveillance of SARS-CoV-2 using long-range PCR primers
- Effects of nonpharmaceutical interventions during COVID-19 pandemic on pediatric asthma exacerbations and viral infections
- Genomic Surveillance of SARS-CoV-2 Using Long-Range PCR Primers
- Severe Acute Respiratory Syndrome Coronavirus-2 Lambda Variant Collected from a Child from Arkansas and Sequenced
Showing 5 of 8 shared publications
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- SARS-CoV-2 Infection Mitigation Strategies Concomitantly Reduce Group A Streptococcus Pharyngitis
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas
- Pediatric SARS-CoV-2 seroprevalence in Arkansas over the first year of the COVID-19 pandemic
Showing 5 of 7 shared publications
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
- Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas
- Pediatric SARS-CoV-2 seroprevalence in Arkansas over the first year of the COVID-19 pandemic
Showing 5 of 6 shared publications
- Development of ACE2 autoantibodies after SARS-CoV-2 infection
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
- Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas
Showing 5 of 6 shared publications
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
- Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas
Showing 5 of 6 shared publications
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas
- Pediatric SARS-CoV-2 seroprevalence in Arkansas over the first year of the COVID-19 pandemic
- Integrative Proteomics and Phosphoproteomics of Asthmatic Airways following RV Infection
- Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
- Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas
- A longitudinal study of SARS-CoV-2 antibody seroprevalence and mitigation behaviors among college students at an Arkansas University
- Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
- Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas
- Pediatric SARS-CoV-2 seroprevalence in Arkansas over the first year of the COVID-19 pandemic
- Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies
- Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
- State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
- Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas
- A longitudinal study of SARS-CoV-2 antibody seroprevalence and mitigation behaviors among college students at an Arkansas University
- SARS-CoV-2 pandemic non-pharmacologic interventions temporally associated with reduced pediatric infections due to <i>Mycoplasma pneumoniae</i> and co-infecting respiratory viruses in Arkansas
- SARS-CoV-2 Infection Mitigation Strategies Concomitantly Reduce Group A Streptococcus Pharyngitis
- Effects of nonpharmaceutical interventions during COVID-19 pandemic on pediatric asthma exacerbations and viral infections
- Severe Acute Respiratory Syndrome Coronavirus-2 Lambda Variant Collected from a Child from Arkansas and Sequenced
- SARS-CoV-2 Pandemic Non-Pharmacologic Interventions Temporally Associated with Reduced Pediatric Infections Due to <i>Mycoplasma pneumoniae</i> and Co-Infecting Respiratory Viruses in Arkansas
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