Laura Phillips James

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

◆ ARA Academy Federal Grant PI

Director, Translational Research Institute

UAMS primary UA Little Rock University of Arkansas

Also affiliated: Northwestern University (2018); University of North Carolina at Chapel Hill (2017); Tufts University (2017); Cincinnati Children's Hospital Medical Center (2005); National Institutes of Health (2000–2001); Arkansas Children's Hospital (1995–2024); Children's Hospital of Orange County (2008); Translational Research Institute (2018); Children's Mercy Hospital (1998–2008); University of Louisville (2001); Medical University of South Carolina (2018); University of Pittsburgh (1998); University of California, San Francisco (2009–2018); Baylor College of Medicine (2018); Virginia Commonwealth University (2018); East Carolina University (2018); Medical College of Wisconsin (2009–2010); VA Palo Alto Health Care System (2015); University of Utah (2008); University of Michigan (2012–2015); University of Arkansas Medical Center (2004–2023); University of Mississippi Medical Center (2005); University of Alabama at Birmingham (1995–1996); University of California San Diego (2000–2009); Rady Children's Hospital-San Diego (2000); Cayman Chemical (United States) (2012); VA Ann Arbor Healthcare System (2015); Kosair Children's Hospital (2001); Michigan Medicine (2012–2015); Universitätsklinikum Aachen (2015); Children's Hospital of Pittsburgh (1998); Arkansas State Crime Laboratory (2011–2012); Eunice Kennedy Shriver National Institute of Child Health and Human Development (2000–2001); Rainbow Babies & Children's Hospital (2000); Eisai (United States) (2005); University Hospital Ulm (2015); Arkansas Department of Health (2011–2012); Wyeth (2005–2008); Arkansas Children's Research Institute (2005–2023); Case Western Reserve University (2000); Washington State University (2017); University of Missouri–Kansas City (1998–2008); The University of Texas Southwestern Medical Center (2009–2018); Michigan State University (2015)

52 h-index 270 pubs 10,522 cited

Research Areas

Biomedical Subjects

Links

ORCID

OverviewAI-generated summary

Laura Phillips James directs the Translational Research Institute at the University of Arkansas for Medical Sciences. Her research focuses on understanding the mechanisms of drug-induced liver injury, particularly related to acetaminophen toxicity. She has investigated the role of metabolic activation, reactive oxygen and nitrogen species, and mitochondrial permeability transition in acetaminophen-induced liver necrosis. Her work also includes the development and application of methods to measure acetaminophen-protein adducts in both animal models and human serum to assess toxicity levels.

Phillips James has also explored the effects of N-acetylcysteine on acetaminophen toxicity in mice, examining the relationship to reactive nitrogen and cytokine formation. Her research interests extend to severe toxicity following the ingestion of synthetic cannabinoids and the oncogenic and tumor suppressor functions of specific genes in liver cancer. She is a member of the ARA Academy, holding the designation of ARA Fellow, and her research area is identified as Pediatric Pharmacology.

With a career marked by extensive scholarship, Phillips James has an h-index of 53 and has authored over 286 publications, which have garnered more than 10,681 citations. She has a robust network of collaborators at the University of Arkansas for Medical Sciences, including Joshua L. Kennedy, Jessica Snowden, Jeffery H. Moran, and Karl W. Boehme, with whom she has co-authored multiple publications.

Metrics

h-index: 52
Publications: 270
Citations: 10,522

Positions

Director, Translational Research Institute 1994–present

University of Arkansas for Medical Sciences Pediatrics ORCID

Selected Publications

NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen (2025)

Toxicological Sciences 5 citations DOI OpenAlex
Vaccine hesitancy or hesitancies? A latent class analysis of pediatric patients' parents (2025)

1 citation DOI OpenAlex
Development of clinical assays for determination of acetaminophen protein adducts (2024)

1 citation DOI OpenAlex
Differentiating Ischemic Hepatitis from Acetaminophen Overdose in Acute Liver Failure: Role of Acetaminophen Adducts—Ischemic Hepatitis vs Acetaminophen Overdose (2024)

Digestive Diseases and Sciences 3 citations DOI OpenAlex
Association of Acetaminophen (Paracetamol) Use With Severity and Outcomes in Patients With Viral Hepatitis-Associated Acute Liver Failure (2024)

The American Journal of Gastroenterology 7 citations DOI OpenAlex
Physiologically‐based pharmacokinetic modeling of pantoprazole to evaluate the role of CYP2C19 genetic variation and obesity in the pediatric population (2024)

CPT Pharmacometrics & Systems Pharmacology 5 citations DOI OpenAlex
115 Strategies for Training and Advancing under-represented Researchers (STARs) (2024)

DOI OpenAlex
Scientia pro bono humani generis: Science for the benefit of humanity (2024)

1 citation DOI OpenAlex
Vitamin D Oral Replacement in Children With Obesity Related Asthma: VDORA1 Randomized Clinical Trial (2023)

Clinical Pharmacology & Therapeutics 8 citations DOI OpenAlex
Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult (2023)

Molecular Metabolism 28 citations DOI OpenAlex
Hands-Free Analytical Urine Testing Technology Validated for Drug-Facilitated Crime Investigations (2023)

Chemical Research in Toxicology 5 citations DOI OpenAlex
Pharmacokinetics of Oral Vitamin D in Children with Obesity and Asthma (2023)

Clinical Pharmacokinetics 7 citations DOI OpenAlex
A longitudinal study of SARS-CoV-2 antibody seroprevalence and mitigation behaviors among college students at an Arkansas University (2023)

1 citation DOI OpenAlex
Development of a clinical and translational research curriculum for undergraduate students (2023)

Journal of Clinical and Translational Science 7 citations DOI OpenAlex
235 Use of Community Review Boards to Evaluate the Utility of the ICF Navigator - A Browser-based Tool to Create Plain-Language Informed Consent Forms (2023)

1 citation DOI OpenAlex

View all publications on OpenAlex →

ARA Academy 2015 ARA Fellow

Dr. James has served as a pediatrician and UAMS faculty member since 1994. Her research training focused on pediatric pharmacology studies in children, supported by the NIH through the Pediatric Pharmacology Research Unit Network, with emphasis on guiding the dosing of a number of pediatric therapeutics. She now leads the Translational Research Institute at UAMS.

Policy Impact

Leads the UAMS Translational Research Institute, accelerating the translation of laboratory discoveries into clinical treatments that benefit patients across Arkansas.