Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-09
Y
Yuet‐Kin Leung
High Impact
Associate Professor
Also affiliated: Tufts University (2004); State University of New York (2011); University of Massachusetts Chan Medical School (2003–2006); Chinese University of Hong Kong (1998–2005); National Institute for Occupational Safety and Health (2015); University of Arkansas Medical Center (2020–2026); Cincinnati Health Department (2017); University at Albany, State University of New York (2011); Central Arkansas Veterans Healthcare System (2020–2024); University of Cincinnati (2006–2026); University of Cincinnati Medical Center (2010–2026)
Pharmacology & Toxicology, College of Medicine
34 h-index
110 pubs
3,924 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Yuet‐Kin Leung's research focuses on the molecular mechanisms underlying disease, particularly in the context of environmental exposures and epigenetics. His work investigates how factors such as arsenic exposure can lead to intergenerational effects on sperm quality, as evidenced by his co-PI role on an NIH/National Institute of Environmental Health Sciences grant totaling $468,131.
Leung's publications explore the dynamic regulation of gene expression, including the role of DNA methylation in prostate cancer development and metastasis. He has also examined androgenic regulation of oxidative stress in the rat prostate and reviewed the significance of estrogen receptor-beta isoforms in understanding cellular signaling. His research interests extend to environmental epigenetics and its implications for disease risk and health outcomes, particularly concerning developmental origins of reproductive disorders.
With an h-index of 40 and over 5,500 citations across 143 publications, Leung is recognized as a highly cited researcher. He actively leads a research group and collaborates with colleagues at the University of Arkansas for Medical Sciences, including Shuk-Mei Ho, Brendan Frett, Anupreet Kharbanda, and Phuc Tran.
Metrics
- h-index: 34
- Publications: 110
- Citations: 3,924
Positions
-
Associate Professor 2019–presentUniversity of Arkansas for Medical Sciences Pharmacology & Toxicology, College of Medicine Institutional directory
-
Associate Professor 2005–2019University of Cincinnati Environmental Health ORCID
Selected Publications
-
Service Year-Dependent Disruption of Reproductive Hormones and Altered DNA Methylation in Male Firefighters (2026)
-
A transcriptomic-driven segmentation and cell simulation framework for high-resolution spatial transcriptomics and cell-cell communication (2026)
-
CD5L promotes efferocytosis and resolution of retinal ischemic injury (2026)
-
Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta (2025)
-
Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns (2025)
-
Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology (2024)
-
Endocrine-Disrupting Chemicals: A Looming Threat to Current and Future Generations (2024)
-
Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells (2024)
-
The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β‐catenin Signaling via Epigenetic Dysregulation that Enhances Sp1‐β catenin‐p300 Interactions in Hepatocellular Carcinoma (2024)
-
Abstract 3011: The loss of an orphan nuclear receptor NR2E3 augments Wnt/β-Catenin signaling via epigenetic dysregulation that links to the Sp1-β catenin-p300 interactions in hepatocellular carcinoma (2024)
-
Abstract 6282: Novel androgen related gene network in prostate cancer cell model (2024)
-
Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach (2023)
-
An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L (2023)
-
Stem Cell Theory of Cancer: Clinical Implications of Epigenomic versus Genomic Biomarkers in Cancer Care (2023)
-
N-(3-Methoxyphenyl)-6-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)pyridin-2-amine is an inhibitor of the FLT3-ITD and BCR-ABL pathways, and potently inhibits FLT3-ITD/D835Y and FLT3-ITD/F691L secondary mutants (2023)
Federal Grants 1 $468,131 total
NIH
Co-PI
Apr 2022 - Jan 2027
RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm quality
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- DNA methylation markers associated with exposure and adverse health outcomes in Veterans exposed to airborne hazards from open burn pits DOD Co-Investigator
- NSF, RII Track-2 FEC: Facilitating Ubiquitous Technology Utilizing Resilient Eco-friendly Sensors (FUTURE Sensors) National Science Foundation via Louisiana Tech University Co-Investigator
Collaboration Network
Top Collaborators
Shuk‐Mei Ho
University of Arkansas for Medical Sciences
13 shared publications
In database
- A novel Cas9-targeted long-read assay for simultaneous detection of IDH1/2 mutations and clinically relevant MGMT methylation in fresh biopsies of diffuse glioma
- Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
- The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β‐catenin Signaling via Epigenetic Dysregulation that Enhances Sp1‐β catenin‐p300 Interactions in Hepatocellular Carcinoma
- Three-Generation Study of Male Rats Gestationally Exposed to High Butterfat and Bisphenol A: Impaired Spermatogenesis, Penetrance with Reduced Severity
Showing 5 of 13 shared publications
Hongyu Li
University of Arkansas for Medical Sciences (US)
7 shared publications
- Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L
- Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
Showing 5 of 7 shared publications
Lingtian Zhang
University of Arkansas for Medical Sciences (US)
5 shared publications
- Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
- Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology
Brendan Frett
University of Arkansas for Medical Sciences
5 shared publications
In database
- Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
- Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology
Anupreet Kharbanda
University of Arkansas for Medical Sciences
4 shared publications
In database
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
- Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology
Phuc Tran
University of Arkansas for Medical Sciences
4 shared publications
In database
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L
- Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors
- Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology
Xiuqi Wang
University of Arkansas for Medical Sciences
4 shared publications
In database
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
- An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L
- N-(3-Methoxyphenyl)-6-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)pyridin-2-amine is an inhibitor of the FLT3-ITD and BCR-ABL pathways, and potently inhibits FLT3-ITD/D835Y and FLT3-ITD/F691L secondary mutants
Jagadeesh Puvvula
California University of Pennsylvania (US)
4 shared publications
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
- Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach
- Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns
- Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta
Joseph M. Braun
Brown University (US)
4 shared publications
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
- Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach
- Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns
- Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta
Emily DeFranco
University of Kentucky (US)
4 shared publications
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
- Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach
- Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns
- Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta
Shouxiong Huang
Texas Biomedical Research Institute (US)
4 shared publications
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
- Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach
- Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns
- Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta
Ann M. Vuong
University of Nevada, Las Vegas (US)
4 shared publications
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
- Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach
- Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns
- Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta
Stephani S. Kim
Battelle (US)
4 shared publications
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
- Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach
- Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns
- Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta
Zana Percy
University of Cincinnati (US)
4 shared publications
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
- Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach
- Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns
- Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta
Aimin Chen
California University of Pennsylvania (US)
4 shared publications
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
- Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach
- Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns
- Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta
Similar Researchers
Based on overlapping research topics
Shuk-Mei Ho
University of Arkansas for Medical Sciences
Environmental Health Research
Epigenetics and DNA Methylation
Prostate Cancer Treatment and Research
Justin N. Treas
University of Arkansas for Medical Sciences
Epigenetics and DNA Methylation
Prostate Cancer Treatment and Research
Pharmacological Effects and Toxicity Studies
Brannon G. Broadfoot
University of Arkansas for Medical Sciences
Environmental Health Research
Epigenetics and DNA Methylation
Pharmacological Effects and Toxicity Studies
Igor Koturbash
University of Arkansas for Medical Sciences
Environmental Health Research
Epigenetics and DNA Methylation
Disease Mechanisms Research
Michelle M. Vanlandingham
National Center for Toxicological Research
Environmental Health Research
Receptor Mechanisms and Signaling
Pharmacological Effects and Toxicity Studies
Olena Levurdiak
University of Arkansas for Medical Sciences
Epigenetics and DNA Methylation
Receptor Mechanisms and Signaling
Disease Mechanisms Research