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Presence
Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-09
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Brian Storrie
Federal Grant PI
High Impact
Professor
Also affiliated: California Institute of Technology (1970–1973); National Institutes of Health (2024); Memorial Sloan Kettering Cancer Center (1976); University of Arkansas Medical Center (2019); European Molecular Biology Laboratory (1992–2000); European Molecular Biology Laboratory (1992–2000); Virginia Tech (1977–2007); University of Colorado Denver (1973–1974); University of California, Berkeley (1977)
Physiology & Cell Biology, College of Medicine
44 h-index
183 pubs
6,712 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Brian Storrie's research focuses on cellular transport and organelle function, particularly the pathways involved in intracellular trafficking and the localization of proteins within cells. His work has investigated the movement of molecules between the Golgi apparatus and the endoplasmic reticulum, exploring mechanisms that govern protein recycling and the scattering of cellular structures. Storrie has also examined the specific processes within blood platelets, including the packaging and release of key proteins like von Willebrand factor and fibrinogen, and their roles in hemostasis and thrombosis.
His research group has also delved into the role of autophagy in platelet activation and its implications for hemostasis. Storrie's work has utilized advanced microscopy techniques, such as three-dimensional holographic fluorescence microscopy, to quantitatively map protein distribution within subcellular compartments. His federal grant funding includes a $624,823 award from the NIH/National Heart Lung and Blood Institute to study the structure and function determinants of puncture wound thrombus formation. Storrie is a highly cited researcher with 184 publications and over 6,600 citations.
Metrics
- h-index: 44
- Publications: 183
- Citations: 6,712
Positions
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Professor 2023–presentUniversity of Arkansas for Medical Sciences Physiology & Cell Biology, College of Medicine Institutional directory
Selected Publications
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Murine thrombus organization limits access to high platelet activation states while supporting platelet recruitment (2026)
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BPS2026 – Machine learning analysis of cellular remodeling during occlusive blood clot formation (2026)
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The Syk inhibitor BI 1002494 impairs thrombus infill in a murine femoral artery occlusion without affecting hemostasis (2025)
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Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets (2025)
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Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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BPS2025 - Machine vision pipeline to elucidate structural underpinnings of blood clot formation (2025)
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Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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Differential Platelet Spatial Morphodynamics in Response to Local Signaling Environments Within a Jugular Puncture Wound Thrombus (2025)
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Differential Effects of GPVI Deletion and SYK Inhibition on Thrombus Organization and Platelet Adhesion in a Murine Jugular Puncture Wound Model (2024)
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U-Net Ensembles for Segmentation of High-Density Cell Populations and Organelles (2024)
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Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation (2024)
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Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis (2024)
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JoVE Video Dataset (2024)
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Trained image analysis techniques for characterizing cell phenotype in electron microscopy images of mouse thrombi (2024)
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Screening for Key Structural Differences in Thrombosis Versus Hemostasis through Single Platelet Analysis (2023)
Federal Grants 1 $624,823 total
NIH
Contact PI
Sep 2021 - Aug 2025
Resubmission: Structure/Function Determinants of Puncture Wound Thrombus Formation
Research Interests
Research search concentrates on how platelet secretion and aggregation properties structure thrombus formation asd provide structure based therapeutic targets. Much of the research uses volume electronn microscopy as a 3D structural approach to puncture wound thrombi and occlusive clots. Mechanism is approached through the use of mouse genetic knockouts and inhibitory drugs of clinical significance.
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- 120 kV FEI Electron Microscope and Supporting Sample Preparation Equipment for Biological Microscopy National Science Foundation Principal Investigator
- Platelet Exocytosis and Endocytosis in Thrombosis and Immunity NIH/Nat. Heart, Lung & Blood Institute via University of Kentucky Research Foundation Principal Investigator
- STRUCTURAL ORGANIZATION OF THE MAMMALIAN GOLGI COMPLEX NIH Principal Investigator
- Structural, Functional,and Molecular Characterization of Platelet alpha-Granule Subpopulations American Heart Association (Midwest Affiliate) Principal Investigator
- Storrie EM NSF COM Commitment Acct UAMS College of Medicine Principal Investigator
- Mechanisms of Golgi Apparatus Protein Recycling NIH Principal Investigator
- Development of a Holographic Fluorescence Microscope (subcontract with Johns Hopkins University) National Science Foundation Principal Investigator
- Melanocortin-4 Receptor Traffic and Signaling NIH Co-Investigator
- In vivo multifunctional photothermal cytometry National Science Foundation Principal Investigator
- Studies of Physiologic and Pathologic Platelet Plug formation- NIH/Nat. Heart, Lung & Blood Institute via University of Pennsylvania Medical Center Principal Investigator
- Role of Rab Proteins in Golgi Apparatus Structure and Function NIH Principal Investigator
- 3D Holographic and 2-Photon Super-Resolution Microscopy US Department of Commerce Principal Investigator
- PROCESSING OF PINOCYTIC VESICLES IN FIBROBLASTS NIH Principal Investigator
- Platelet Endocytosis in Hemostasis and Innate Immunity- Resubmission - Continuation - Continuation NIH/Nat. Heart, Lung & Blood Institute via University of Kentucky Research Foundation Principal Investigator
- Integrated Photothermal Nanoprobes NIH Co-Investigator
- Functional Analysis of the conserved oligomeric Golgi (COG) complex in yeast National Science Foundation Principal Investigator
- COM Bridging Award UAMS College of Medicine Principal Investigator
- Non-canonical pathways of Golgi apparatus protein recycling National Science Foundation Principal Investigator
- Summer 2007 Supplement to Non-canonical pthways National Science Foundation Principal Investigator
- Characterization of Mammalian COG Complex-Interacting Golgi Trafficking Machinery UAMS Internal Research Awards Principal Investigator
- Investigating hemostasis and thrombosis at the systems level NIH/National Heart Lung Blood Institue Co-Investigator
- Super-Res Holographic Microscopy to Advance Research on Golgi Apparatus Function NIH Principal Investigator
- Mechanisms of Golgi Apparatus Assembly National Science Foundation Principal Investigator
- Super-Resolution Light Microscope at University of Arkansas for Medical Sciences NIH Principal Investigator
- PROTEIN RETENTION IN THE MAMMALIAN GOLGI APPARATUS NIH Principal Investigator
- Structure/Function Determinants of Platelet Granule Secretion NIH Principal Investigator
- MECHANISMS OF LYSOSOMAL ASSEMBLY IN FIBROBLASTS NIH Principal Investigator
- Structure/Function Determinants of Platelet Granule Secretion - Resubmission NIH Principal Investigator
Collaboration Network
Top Collaborators
Irina D. Pokrovskaya
University of Arkansas for Medical Sciences
46 shared publications
In database
- 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
- STEM tomography reveals that the canalicular system and α‐granules remain separate compartments during early secretion stages in blood platelets
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures
Showing 5 of 46 shared publications
Maria A. Aronova
National Institutes of Health (US)
30 shared publications
- 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
- STEM tomography reveals that the canalicular system and α‐granules remain separate compartments during early secretion stages in blood platelets
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures
Showing 5 of 30 shared publications
Richard D. Leapman
National Institutes of Health (US)
30 shared publications
- 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
- STEM tomography reveals that the canalicular system and α‐granules remain separate compartments during early secretion stages in blood platelets
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures
Showing 5 of 30 shared publications
Sidney W. Whiteheart
University of Kentucky (US)
19 shared publications
- Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis
- Cellubrevin/vesicle-associated membrane protein-3–mediated endocytosis and trafficking regulate platelet functions
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Alterations in platelet secretion differentially affect thrombosis and hemostasis
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
Showing 5 of 19 shared publications
Jeffrey A. Kamykowski
University of Arkansas for Medical Sciences
17 shared publications
In database
- Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet α-granules
- Electron T omography R eveals R ab6 I s E ssential to the T rafficking of trans‐ G olgi C lathrin and COPI ‐ C oated V esicles and the M aintenance of G olgi C isternal N umber
- 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
- STEM tomography reveals that the canalicular system and α‐granules remain separate compartments during early secretion stages in blood platelets
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
Showing 5 of 17 shared publications
Smita Joshi
University of Kentucky (US)
15 shared publications
- Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis
- Cellubrevin/vesicle-associated membrane protein-3–mediated endocytosis and trafficking regulate platelet functions
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Alterations in platelet secretion differentially affect thrombosis and hemostasis
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
Showing 5 of 15 shared publications
Sung W. Rhee
University of Arkansas for Medical Sciences
14 shared publications
In database
- The Steady‐State Distribution of Glycosyltransferases Between the Golgi Apparatus and the Endoplasmic Reticulum is Approximately 90:10
- Capacity of the Golgi Apparatus for Cargo Transport Prior to Complete Assembly
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
Showing 5 of 14 shared publications
Kelly K. Ball
University of Arkansas for Medical Sciences
12 shared publications
In database
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis
Showing 5 of 12 shared publications
Shijie Liu
University of Arkansas for Medical Sciences (US)
10 shared publications
- Are Rab proteins the link between Golgi organization and membrane trafficking?
- Rab proteins as major determinants of the Golgi complex structure
- How Rab Proteins Determine Golgi Structure
- GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells
- Distinct Sets of Rab6 Effectors Contribute to ZW10 ‐ and COG ‐Dependent Golgi Homeostasis
Showing 5 of 10 shared publications
Michael W. Webb
University of Arkansas for Medical Sciences
8 shared publications
In database
- Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
- Theme and Variation: Structuring Thrombus Formation from Jugular/Arterial Puncture Wounds to Occlusive Clots in a Mouse Model
- Screening for Key Structural Differences in Thrombosis Versus Hemostasis through Single Platelet Analysis
- Differential Effects of GPVI Deletion and SYK Inhibition on Thrombus Organization and Platelet Adhesion in a Murine Jugular Puncture Wound Model
Showing 5 of 8 shared publications
Andrew A. Prince
University of Arkansas for Medical Sciences
5 shared publications
In database
- STEM tomography reveals that the canalicular system and α‐granules remain separate compartments during early secretion stages in blood platelets
- Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures
- Comparison of 3D cellular imaging techniques based on scanned electron probes: Serial block face SEM vs. Axial bright-field STEM tomography
- Scanning Transmission Electron Tomography of Blood Platelets in Thick Sections
- Bright-Field STEM Tomography of Blood Platelets in Thick Sections
Shilpi Yadav
University of Arkansas for Medical Sciences (US)
5 shared publications
- The cellular basis of platelet secretion: Emerging structure/function relationships
- 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
- Cellubrevin/vesicle-associated membrane protein-3–mediated endocytosis and trafficking regulate platelet functions
- Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures
- Alpha-Granules in Resting Human Platelets Are a Spatially Clustered, Single Major Population
E.L. McBride
National Institute of Biomedical Imaging and Bioengineering (US)
5 shared publications
- 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
- Comparison of 3D cellular imaging techniques based on scanned electron probes: Serial block face SEM vs. Axial bright-field STEM tomography
- Comparison of 3-D Cell and Tissue Imaging Techniques Based on Scanning Electron Probes
- Alpha-Granules in Resting Human Platelets Are a Spatially Clustered, Single Major Population
- Comparison of 3-D Cellular Imaging Techniques using Scanned Electron Probes
Shu Jiang
University of Arkansas for Medical Sciences (US)
4 shared publications
- Cisternal Rab Proteins Regulate Golgi Apparatus Redistribution in Response to Hypotonic Stress
- Capacity of the Golgi Apparatus for Cargo Transport Prior to Complete Assembly
- Shiga‐like Toxin Subunit B (SLTB)‐Enhanced Delivery of Chlorin e6 (Ce6) Improves Cell Killing
- Dynamic Nucleation of Golgi Apparatus Assembly from the Endoplasmic Reticulum in Interphase HeLa Cells
Meenakshi Banerjee
University of Kentucky (US)
4 shared publications
- Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis
- Cellubrevin/vesicle-associated membrane protein-3–mediated endocytosis and trafficking regulate platelet functions
- Alterations in platelet secretion differentially affect thrombosis and hemostasis
- Autophagy in Platelets
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