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OverviewAI-generated summary
Irina D. Pokrovskaya's research focuses on cellular transport mechanisms, particularly within the Golgi apparatus and related vesicular trafficking pathways. Her work investigates the role of protein complexes, such as the conserved oligomeric Golgi (COG) complex, and specific proteins like syntaxin-5, in regulating intra-Golgi recycling and protein transport. Pokrovskaya has explored the impact of COG complex inactivation on Golgi function and the nature of intra-Golgi recycling vesicles.
Her research extends to the study of platelet function and cargo packaging, examining how proteins like serglycin affect α-granule content and release. Pokrovskaya has also applied advanced techniques, including deep learning and 3D ultrastructural analysis, to investigate organelle packing in platelets derived from COVID-19 patients. Additionally, her work includes the development and characterization of cellular models for COG complex-related congenital disorders of glycosylation (CDG-II diseases), and the role of the COG complex in the parasite *Toxoplasma gondii*.
Metrics
- h-index: 26
- Publications: 84
- Citations: 2,071
Selected Publications
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Murine Thrombus Organization Limits Access to High Platelet Activation States While Supporting Platelet Recruitment (2026)
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BPS2026 – Machine learning analysis of cellular remodeling during occlusive blood clot formation (2026)
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The Syk inhibitor BI 1002494 impairs thrombus infill in a murine femoral artery occlusion without affecting hemostasis (2025)
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Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets (2025)
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Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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Acute <scp>GARP</scp> Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and <i>O</i> ‐Glycosylation (2025)
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BPS2025 - Machine vision pipeline to elucidate structural underpinnings of blood clot formation (2025)
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Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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Differential Effects of GPVI Deletion and SYK Inhibition on Thrombus Organization and Platelet Adhesion in a Murine Jugular Puncture Wound Model (2024)
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Acute GARP depletion disrupts vesicle transport, leading to severe defects in sorting, secretion, and O-glycosylation (2024)
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Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation (2024)
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Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis (2024)
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JoVE Video Dataset (2024)
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Trained image analysis techniques for characterizing cell phenotype in electron microscopy images of mouse thrombi (2024)
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Screening for Key Structural Differences in Thrombosis Versus Hemostasis through Single Platelet Analysis (2023)
Collaboration Network
Top Collaborators
Brian Storrie
University of Arkansas for Medical Sciences
28 shared publications
In database
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
Showing 5 of 28 shared publications
Maria A. Aronova
National Institute of Biomedical Imaging and Bioengineering (US)
16 shared publications
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
Showing 5 of 16 shared publications
Richard D. Leapman
National Institute of Biomedical Imaging and Bioengineering (US)
16 shared publications
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
Showing 5 of 16 shared publications
Kelly K. Ball
University of Arkansas for Medical Sciences
12 shared publications
In database
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
Showing 5 of 12 shared publications
Vladimir Lupashin
11 shared publications
In database
- Development and Initial Characterization of Cellular Models for COG Complex-Related CDG-II Diseases
- Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra‐Golgi recycling vesicles
- Essential role of the conserved oligomeric Golgi complex in <i>Toxoplasma gondii</i>
- STX5’s flexibility in SNARE pairing supports Golgi functions
- Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System
Showing 5 of 11 shared publications
Sung W. Rhee
University of Arkansas for Medical Sciences
10 shared publications
In database
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
Showing 5 of 10 shared publications
Sidney W. Whiteheart
University of Kentucky (US)
8 shared publications
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
- Theme and Variation: Structuring Thrombus Formation from Jugular/Arterial Puncture Wounds to Occlusive Clots in a Mouse Model
Showing 5 of 8 shared publications
Jeffrey A. Kamykowski
University of Arkansas for Medical Sciences
8 shared publications
In database
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Trained image analysis techniques for characterizing cell phenotype in electron microscopy images of mouse thrombi
Showing 5 of 8 shared publications
Michael W. Webb
University of Arkansas for Medical Sciences
8 shared publications
In database
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
- Theme and Variation: Structuring Thrombus Formation from Jugular/Arterial Puncture Wounds to Occlusive Clots in a Mouse Model
- Screening for Key Structural Differences in Thrombosis Versus Hemostasis through Single Platelet Analysis
- Differential Effects of GPVI Deletion and SYK Inhibition on Thrombus Organization and Platelet Adhesion in a Murine Jugular Puncture Wound Model
- Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
Showing 5 of 8 shared publications
Smita Joshi
University of Kentucky (US)
7 shared publications
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
- Theme and Variation: Structuring Thrombus Formation from Jugular/Arterial Puncture Wounds to Occlusive Clots in a Mouse Model
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
Showing 5 of 7 shared publications
D. Cruz
7 shared publications
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Quantitative analysis with deep learning segmentation and modeling of 3D electron microscopy data
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
Showing 5 of 7 shared publications
Douglas J. Palumbo
5 shared publications
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Quantitative analysis with deep learning segmentation and modeling of 3D electron microscopy data
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
- Combined use of serial block face SEM and focused ion beam SEM elucidates the 3D ultrastructure of blood platelets and thrombi
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
Rahul R. Akkem
5 shared publications
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Quantitative analysis with deep learning segmentation and modeling of 3D electron microscopy data
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
- Combined use of serial block face SEM and focused ion beam SEM elucidates the 3D ultrastructure of blood platelets and thrombi
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
Oliver Zhao
4 shared publications
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
- Differential Platelet Spatial Morphodynamics in Response to Local Signaling Environments Within a Jugular Puncture Wound Thrombus
Farhana Taher Sumya
University of Arkansas for Medical Sciences
4 shared publications
In database
- Development and Initial Characterization of Cellular Models for COG Complex-Related CDG-II Diseases
- Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra‐Golgi recycling vesicles
- Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System
- Acute COG inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles
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