Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
I
Irina D. Pokrovskaya
High Impact
Research Associate
Also affiliated: Arkansas Children's Hospital (2012); Princeton University (1997–1999); University of Arkansas Medical Center (2009–2025); Central Arkansas Veterans Healthcare System (2002–2011); Institute of Bioorganic Chemistry (1991–1994); Institute of Geography (2022); Arkansas Children's Research Institute (2012)
27 h-index
90 pubs
2,179 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Irina D. Pokrovskaya's research focuses on cellular transport mechanisms, particularly involving the Golgi apparatus and SNARE proteins. Her work has investigated the role of conserved oligomeric Golgi (COG) complexes in maintaining Golgi glycosylation machinery and their specific regulation of distinct SNARE complexes. Pokrovskaya has also studied the biological relevance of lipogenic enzymes such as DGAT1, FAS, and LPL in adipose tissue, examining their response to obesity, insulin resistance, and thiazolidinedione (TZD) treatment.
Her research has been supported by grants and collaborations with scientists at the University of Arkansas for Medical Sciences, including Brian Storrie, Vladimir Lupashin, Kelly K. Ball, and Sung W. Rhee. Pokrovskaya has authored or co-authored 86 publications, accumulating over 2,133 citations and an h-index of 27. She is recognized as a highly cited researcher, indicating a significant impact in her fields of study. Her recent work extends to areas such as biological earth observation using animal sensors, demonstrating a breadth of research interests.
Metrics
- h-index: 27
- Publications: 90
- Citations: 2,179
Positions
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Research Associate publications 2002–2026University of Arkansas for Medical Sciences Physiology and Cell Biology ORCID
Selected Publications
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Golgi CATCHR complexes function as organizing hubs for vesicle tethering and fusion (2026)
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Murine thrombus organization limits access to high platelet activation states while supporting platelet recruitment (2026)
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BPS2026 – Machine learning analysis of cellular remodeling during occlusive blood clot formation (2026)
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The Syk inhibitor BI 1002494 impairs thrombus infill in a murine femoral artery occlusion without affecting hemostasis (2025)
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Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets (2025)
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Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O ‐Glycosylation (2025)
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BPS2025 - Machine vision pipeline to elucidate structural underpinnings of blood clot formation (2025)
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Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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Differential Platelet Spatial Morphodynamics in Response to Local Signaling Environments Within a Jugular Puncture Wound Thrombus (2025)
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Differential Effects of GPVI Deletion and SYK Inhibition on Thrombus Organization and Platelet Adhesion in a Murine Jugular Puncture Wound Model (2024)
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U-Net Ensembles for Segmentation of High-Density Cell Populations and Organelles (2024)
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Acute GARP depletion disrupts vesicle transport, leading to severe defects in sorting, secretion, and O-glycosylation (2024)
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Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation (2024)
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Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis (2024)
Collaboration Network
Top Collaborators
Brian Storrie
University of Arkansas for Medical Sciences
47 shared publications
In database
- 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
- STEM tomography reveals that the canalicular system and α‐granules remain separate compartments during early secretion stages in blood platelets
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures
Showing 5 of 47 shared publications
Maria A. Aronova
National Institutes of Health (US)
30 shared publications
- 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
- STEM tomography reveals that the canalicular system and α‐granules remain separate compartments during early secretion stages in blood platelets
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures
Showing 5 of 30 shared publications
Richard D. Leapman
National Institutes of Health (US)
30 shared publications
- 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
- STEM tomography reveals that the canalicular system and α‐granules remain separate compartments during early secretion stages in blood platelets
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures
Showing 5 of 30 shared publications
Vladimir Lupashin
University of Arkansas for Medical Sciences
26 shared publications
In database
- Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery
- COG complexes form spatial landmarks for distinct SNARE complexes
- The COG Complex, Rab6 and COPI Define a Novel Golgi Retrograde Trafficking Pathway that is Exploited by SubAB Toxin
- COG Complex Complexities: Detailed Characterization of a Complete Set of HEK293T Cells Lacking Individual COG Subunits
- COG6 Interacts with a Subset of the Golgi SNAREs and Is Important for the Golgi Complex Integrity
Showing 5 of 26 shared publications
Sidney W. Whiteheart
University of Kentucky (US)
16 shared publications
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Alterations in platelet secretion differentially affect thrombosis and hemostasis
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
- Autophagy in Platelets
- Structural analysis of resting mouse platelets by 3D-EM reveals an unexpected variation in α-granule shape
Showing 5 of 16 shared publications
Jeffrey A. Kamykowski
University of Arkansas for Medical Sciences
13 shared publications
In database
- 3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
- STEM tomography reveals that the canalicular system and α‐granules remain separate compartments during early secretion stages in blood platelets
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Structural analysis of resting mouse platelets by 3D-EM reveals an unexpected variation in α-granule shape
Showing 5 of 13 shared publications
Smita Joshi
University of Kentucky (US)
13 shared publications
- SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets
- Alterations in platelet secretion differentially affect thrombosis and hemostasis
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
- Autophagy in Platelets
- Structural analysis of resting mouse platelets by 3D-EM reveals an unexpected variation in α-granule shape
Showing 5 of 13 shared publications
Sung W. Rhee
University of Arkansas for Medical Sciences
12 shared publications
In database
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
Showing 5 of 12 shared publications
Kelly K. Ball
University of Arkansas for Medical Sciences
12 shared publications
In database
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis
Showing 5 of 12 shared publications
Tetyana Kudlyk
University of Arkansas for Medical Sciences
11 shared publications
In database
- Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery
- COG complexes form spatial landmarks for distinct SNARE complexes
- The COG Complex, Rab6 and COPI Define a Novel Golgi Retrograde Trafficking Pathway that is Exploited by SubAB Toxin
- COG6 Interacts with a Subset of the Golgi SNAREs and Is Important for the Golgi Complex Integrity
- More than just sugars: Conserved oligomeric Golgi complex deficiency causes glycosylation‐independent cellular defects
Showing 5 of 11 shared publications
Michael W. Webb
University of Arkansas for Medical Sciences
8 shared publications
In database
- Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
- Theme and Variation: Structuring Thrombus Formation from Jugular/Arterial Puncture Wounds to Occlusive Clots in a Mouse Model
- Screening for Key Structural Differences in Thrombosis Versus Hemostasis through Single Platelet Analysis
- Differential Effects of GPVI Deletion and SYK Inhibition on Thrombus Organization and Platelet Adhesion in a Murine Jugular Puncture Wound Model
Showing 5 of 8 shared publications
Rose Willett
University of Arkansas at Little Rock
7 shared publications
In database
- Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery
- COG complexes form spatial landmarks for distinct SNARE complexes
- The COG Complex, Rab6 and COPI Define a Novel Golgi Retrograde Trafficking Pathway that is Exploited by SubAB Toxin
- COG6 Interacts with a Subset of the Golgi SNAREs and Is Important for the Golgi Complex Integrity
- COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex
Showing 5 of 7 shared publications
Zinia D’Souza
University of Arkansas for Medical Sciences
7 shared publications
In database
- Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosomal System in Human Cells
- Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra‐Golgi recycling vesicles
- Syntaxin‐5's flexibility in SNARE pairing supports Golgi functions
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
- STX5’s flexibility in SNARE pairing supports Golgi functions
Showing 5 of 7 shared publications
Gouri Ranganathan
University of Arkansas Medical Center (US)
5 shared publications
- The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment
- The Translational Regulation of Lipoprotein Lipase by Epinephrine Involves an RNA Binding Complex Including the Catalytic Subunit of Protein Kinase A
- The lipoprotein lipase (LPL) S447X gain of function variant involves increased mRNA translation
- Role of A Kinase Anchor Proteins in the Tissue-Specific Regulation of Lipoprotein Lipase
- Inhibition of LPL by PKCα depletion in adipocytes involves PKA activation
Philip A. Kern
University of Arkansas Medical Center (US)
5 shared publications
- The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment
- The Translational Regulation of Lipoprotein Lipase by Epinephrine Involves an RNA Binding Complex Including the Catalytic Subunit of Protein Kinase A
- The lipoprotein lipase (LPL) S447X gain of function variant involves increased mRNA translation
- Role of A Kinase Anchor Proteins in the Tissue-Specific Regulation of Lipoprotein Lipase
- Inhibition of LPL by PKCα depletion in adipocytes involves PKA activation
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