David W. Gaylor
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Also affiliated: Louisiana State University (1999); Cincinnati Children's Hospital Medical Center (1976); Health Canada (1991); National Institutes of Health (1970); Arkansas Children's Hospital (1999–2010); Environmental Protection Agency (2006–2014); Research Triangle Park Foundation (1969–2003); United States Food and Drug Administration (1979–2001); Electric Power Research Institute (1998); Juniper Networks (United States) (2003); 3M (United States) (2005); Lawrence Berkeley National Laboratory (1995); Eureka College (2005); Zimmer Biomet (Netherlands) (1974); RTI International (1965–1969); University of Würzburg (2003); Saginaw Valley State University (1999); China Medical Board (2013); Triangle (1973); Office of the Director (2001); National Institute of Environmental Health Sciences (1970–1973); Zimmer Biomet (United States) (1986–1997); Cancer Research Center (2003); Office of the Director (1997–1999); Food and Drug Administration (1996–1999); TES International (United States) (2004); Gaylord Hospital (2003–2005); Arkansas Department of Agriculture (2002–2004); Arkansas Foundation for Medical Care (2003); International Association for Dental Research (2002); University of Cincinnati (1976); The University of Texas at Austin (2003)
Formerly Arkansas Affiliated with NCTR, UAMS through 2021.
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
David W. Gaylor's research has primarily focused on dose-response relationships in toxicology and the study of metabolic imbalances associated with specific health conditions, particularly in children. His work has investigated biomarkers of oxidative stress and methylation capacity in children with autism, exploring potential links between metabolic endophenotypes, genotypes, and oxidative stress. Gaylor has also examined abnormal folate metabolism and its potential role as a maternal risk factor for Down syndrome.
His research has explored the efficacy of treatments, such as methylcobalamin and folinic acid, on glutathione redox status in children with autism, and has investigated cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from these children. Gaylor has also contributed to the understanding of dose-dependent transitions in mechanisms of toxicity, using case studies to illustrate these principles.
With a career marked by extensive publication, Gaylor has an h-index of 44 and has authored over 234 publications with more than 8,400 citations. His recent activity indicates ongoing engagement in research.
Metrics
- h-index: 44
- Publications: 234
- Citations: 8,436
Selected Publications
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Dose–Response Relationship and Extrapolation in Toxicology: Mechanistic and Statistical Considerations (2021)
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Dose–Response Relationship and Extrapolation in Toxicology. Mechanistic and Statistical Considerations (2020)
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Dose–Response Relationship and Extrapolation in Toxicology. Mechanistic and Statistical Considerations (2014)
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Extrapolation, Low Dose (2014)
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Degrees of Freedom, Satterthwaite's Approximation to‐I (2014)
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Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status (2013)
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Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism (2011)
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Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism (2009)
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Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism (2008)
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Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism (2008)
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RE: Coleman et al. Feasibility of Exercise During Treatment for Multiple Myeloma. Cancer Nursing. 2003;26(5):410-419. (2008)
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Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism (2006)
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Dose–Response Models in Risk Analysis (2005)
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Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism (2004)
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Feasibility of Exercise During Treatment for Multiple Myeloma (2003)
Collaboration Network
Top Collaborators
- Percentiles of the Product of Uncertainty Factors for Establishing Probabilistic Reference Doses
- A Unified Approach to Risk Assessment for Cancer and Noncancer Endpoints Based on Benchmark Doses and Uncertainty/Safety Factors1
- Mathematical Modeling of Reproductive and Developmental Toxic Effects for Quantitative Risk Assessment
- Using Average Lifetime Dose Rate for Intermittent Exposures to Carcinogens
- Chronic: A SAS procedure for statistical analysis of carcinogenesis studies
Showing 5 of 20 shared publications
- A Unified Approach to Risk Assessment for Cancer and Noncancer Endpoints Based on Benchmark Doses and Uncertainty/Safety Factors1
- Relative Potency of Chemical Carcinogens in Rodents
- Uncertainty in Cancer Risk Estimates
- Using the Biological Two‐Stage Model to Assess Risk from Short‐Term Exposures
- Dose-response modeling of quantitative response data for risk assessment
Showing 5 of 14 shared publications
- Risk assessment for neurotoxic effects.
- Biologically-based dose–response model for neurotoxicity risk assessment
- The role of maternal diet in the developmental toxicology of ethanol
- Concepts on Quantitative Risk Assessment of Neurotoxicants
- BIOLOGICALLY-BASED DOSE-RESPONSE MODEL FOR NEUROTOXICITY RISK ASSESSMENT
Showing 5 of 10 shared publications
- Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
- Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
- Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
- Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
- Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
Showing 5 of 8 shared publications
- Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
- Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
- Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
- Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
- Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism
Showing 5 of 7 shared publications
- No threshold dose for estradiol-induced sex reversal of turtle embryos: how little is too much?
- Uncertainty in Cancer Risk Estimates
- The threshold dose question in teratogenesis
- No Threshold Dose for Estradiol-Induced Sex Reversal of Turtle Embryos: How Little Is Too Much?
- Workshop on Risk Assessment in Reproductive and Developmental Toxicology: Addressing the Assumptions and Identifying the Research Needs
Showing 5 of 6 shared publications
- Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
- Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
- Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
- Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism
- Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism
Showing 5 of 6 shared publications
- Health Risk Assessment Practices in the U.S. Food and Drug Administration
- Alternative tests: carcinogenesis as an example.
- Consensus workshop on the evaluation of maternal and developmental toxicity work group III report: Low dose extrapolation and other considerations for risk assessment–models and applications
- New directions for predicting carcinogenesis
- U.S. Food and Drug Administration perspective of the inclusion of effects of low-level exposures in safety and risk assessment.
- Significance of DNA Adducts at Low Dose: Shortening the Time to Spontaneous Tumor Occurrence
- A carcinogenesis model describing mutational events at the DNA adduct level
- Dose–Response Relationship and Extrapolation in Toxicology. Mechanistic and Statistical Considerations
- Dose–Response Relationship and Extrapolation in Toxicology: Mechanistic and Statistical Considerations
- Dose–Response Relationship and Extrapolation in Toxicology. Mechanistic and Statistical Considerations
- Retrospective study of the relationship between agricultural use of 2,4,5‐T and cleft palate occurrence in Arkansas
- Reduced interlitter variability in rats resulting from a restricted mating period, and reassessment of the “Litter effect”
- Teratological evaluation of FD&C red no. 2—A collaborative government‐industry study. V. Combined findings and discussion
- Teratological evaluation of FD&C red no. 2—A collaborative government‐industry study. I. Introduction, experimental materials, and procedures
- Teratological evaluation of FD&C red no. 2—A collaborative government‐industry study. IV. NCTR's study
- The threshold dose question in teratogenesis
- A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B1in the diet
- Workshop on Risk Assessment in Reproductive and Developmental Toxicology: Addressing the Assumptions and Identifying the Research Needs
- CORRELATION OF BLOOD CHOLINESTERASE LEVELS WITH TOXICITY OF SARIN IN RATS
- Chronic toxicity/carcinogenicity studies of sulphamethazine in Fischer 344/N rats: Two-generation exposure
- Chronic toxicity/carcinogenicity studies of sulphamethazine in B6C3F1 mice
- Chronic toxicity/carcinogenicity studies of gentian violet in fischer 344 rats: Two-generation exposure
- Response to the society of toxicology task force re-examination of the ED01 study
- Chronic Toxicity and Carcinogenicity Studies of Gentian Violet in Mice
- Chronic toxicity/carcinogenicity studies of sulphamethazine in B6C3F1 mice
- Chronic toxicity/carcinogenicity studies of gentian violet in fischer 344 rats: Two-generation exposure
- Bladder and liver tumorigenesis induced by 2‐acetylaminofluorene in different F1mouse hybrids: Variation within genotypes and effects of using more than one genotype on risk assessment
- Chronic toxicity/carcinogenicity studies of sulphamethazine in Fischer 344/N rats: Two-generation exposure
- Chronic toxicity/carcinogenicity studies of sulphamethazine in B6C3F1 mice
- Chronic toxicity/carcinogenicity studies of gentian violet in fischer 344 rats: Two-generation exposure
- Study of sodium saccharin co-carcinogenicity in the rat
- Nonneoplastic changes induced in female c3h mice by chronic exposure to diethylstilbestrol or 17β‐estradiol
- Response to the society of toxicology task force re-examination of the ED01 study
- Occurrence of Tumors Among Litters of BALB/c Female Mice
- Subchronic Studies of Pyrilamine in Fischer 344 Rats
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