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Biography and Research Information
OverviewAI-generated summary
Amrita Khakurel's research focuses on the physiological roles of the Golgi apparatus, particularly the Golgi-associated retrograde protein (GARP) complex. Her work investigates how this complex is essential for maintaining the Golgi's glycosylation machinery, a critical process for protein modification and function. Khakurel has published findings detailing how GARP dysfunction leads to disruptions in vesicle transport, affecting protein sorting, secretion, and O-glycosylation. Her studies have also explored the consequences of GARP depletion, including COPI displacement and depletion of Golgi v-SNAREs and calcium homeostasis proteins. She has contributed to the generation and analysis of cell lines for studying these cellular processes. Khakurel's research network includes collaborators such as Vladimir Lupashin and Irina D. Pokrovskaya from the University of Arkansas for Medical Sciences, with whom she has co-authored multiple publications.
Metrics
- h-index: 7
- Publications: 17
- Citations: 169
Selected Publications
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GARP Complex in Golgi Physiology (2026)
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Acute <scp>GARP</scp> Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and <i>O</i> ‐Glycosylation (2025)
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Acute GARP depletion disrupts vesicle transport, leading to severe defects in sorting, secretion, and O-glycosylation (2024)
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Role of GARP Vesicle Tethering Complex in Golgi Physiology (2023)
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GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins (2022)
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Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines (2022)
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GARP complex controls Golgi physiology by stabilizing COPI machinery and Golgi v-SNAREs (2022)
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Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation (2021)
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The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery (2021)
Collaboration Network
Top Collaborators
Vladimir Lupashin
10 shared publications
In database
- The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery
- Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation
- Role of GARP Vesicle Tethering Complex in Golgi Physiology
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
- Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines
Showing 5 of 10 shared publications
Tetyana Kudlyk
University of Arkansas for Medical Sciences
4 shared publications
In database
- The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
- Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines
- GARP complex controls Golgi physiology by stabilizing COPI machinery and Golgi v-SNAREs
Zinia D’Souza
University of Arkansas for Medical Sciences
3 shared publications
In database
- Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
- GARP complex controls Golgi physiology by stabilizing COPI machinery and Golgi v-SNAREs
I. V. Pokrovskaya
University of Arkansas for Medical Sciences (US)
3 shared publications
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
- Acute GARP depletion disrupts vesicle transport, leading to severe defects in sorting, secretion, and O-glycosylation
- GARP complex controls Golgi physiology by stabilizing COPI machinery and Golgi v-SNAREs
Irina D. Pokrovskaya
3 shared publications
In database
- Acute <scp>GARP</scp> Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and <i>O</i> ‐Glycosylation
- Author response for "Acute <scp>GARP</scp> Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and <i>O</i>‐Glycosylation"
- Author response for "Acute <scp>GARP</scp> Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and <i>O</i>‐Glycosylation"
Walter S. Aragon‐Ramirez
3 shared publications
In database
- Acute <scp>GARP</scp> Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and <i>O</i> ‐Glycosylation
- Author response for "Acute <scp>GARP</scp> Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and <i>O</i>‐Glycosylation"
- Author response for "Acute <scp>GARP</scp> Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and <i>O</i>‐Glycosylation"
Juan S. Bonifacino
National Institutes of Health (US)
1 shared publication
- The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery
Farhana Taher Sumya
University of Arkansas for Medical Sciences
1 shared publication
In database
- Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation
Walter S. Aragon-Ramirez
University of Arkansas for Medical Sciences (US)
1 shared publication
- GARP Complex in Golgi Physiology
Vladimir V. Lupashin
University of Arkansas Medical Center (US)
1 shared publication
- GARP Complex in Golgi Physiology
Similar Researchers
Based on overlapping research topics
Farhana Taher Sumya
University of Arkansas for Medical Sciences
Glycosylation and Glycoproteins Research
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Tetyana Kudlyk
National Center for Toxicological Research
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Dr. Stephanie Byrum
University of Arkansas for Medical Sciences
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Vladimir Lupashin
University of Arkansas for Medical Sciences
Glycosylation and Glycoproteins Research
Cellular transport and secretion
Protein Transport
Shelley Crary
University of Arkansas for Medical Sciences
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Disease Mechanisms Research
Molecular Biology Techniques and Applications
Charles Bower
University of Arkansas for Medical Sciences
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Disease Mechanisms Research
Molecular Biology Techniques and Applications