Zinia D’Souza
Postdoctoral associate
Also affiliated: Tata Memorial Hospital (2017–2018); Advanced Centre for Treatment, Research and Education in Cancer (2017–2018)
Postdoc Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Zinia D’Souza investigates the intricate mechanisms governing cellular transport and protein modification, with a particular focus on the Golgi apparatus and its role in glycosylation. Her research explores how the Golgi's trafficking machinery, including SNARE proteins and adaptor complexes like GARP and COG, influences essential cellular processes. D'Souza's work has illuminated the functional flexibility of proteins such as Syntaxin-5 (STX5) in mediating SNARE pairing and maintaining Golgi homeostasis. She has also examined the consequences of disrupting these pathways, such as COG complex inactivation, which leads to impacts on intra-Golgi recycling vesicles and the depletion of critical Golgi components. Her publications also touch upon the role of GARP complex dysfunction in COPI displacement and calcium homeostasis. D'Souza has a publication record of 13 papers with 347 citations and an h-index of 9. She has collaborated extensively with researchers at the University of Arkansas for Medical Sciences, including Vladimir Lupashin and Irina D. Pokrovskaya.
Metrics
- h-index: 9
- Publications: 13
- Citations: 350
Selected Publications
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Syntaxin‐5's flexibility in <scp>SNARE</scp> pairing supports Golgi functions (2023)
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GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins (2022)
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Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra‐Golgi recycling vesicles (2022)
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GARP complex controls Golgi physiology by stabilizing COPI machinery and Golgi v-SNAREs (2022)
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Acute COG inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles (2022)
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STX5’s flexibility in SNARE pairing supports Golgi functions (2022)
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Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation (2021)
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Golgi inCOGnito: From vesicle tethering to human disease (2020)
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Maintaining order: <scp>COG</scp> complex controls Golgi trafficking, processing, and sorting (2019)
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Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosomal System in Human Cells (2019)
Collaboration Network
Top Collaborators
- Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation
- Syntaxin‐5's flexibility in <scp>SNARE</scp> pairing supports Golgi functions
- Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra‐Golgi recycling vesicles
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
- STX5’s flexibility in SNARE pairing supports Golgi functions
Showing 5 of 7 shared publications
- Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation
- Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra‐Golgi recycling vesicles
- Acute COG inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles
- Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
- GARP complex controls Golgi physiology by stabilizing COPI machinery and Golgi v-SNAREs
- Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra‐Golgi recycling vesicles
- STX5’s flexibility in SNARE pairing supports Golgi functions
- Acute COG inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles
- Syntaxin‐5's flexibility in <scp>SNARE</scp> pairing supports Golgi functions
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
- GARP complex controls Golgi physiology by stabilizing COPI machinery and Golgi v-SNAREs
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
- GARP complex controls Golgi physiology by stabilizing COPI machinery and Golgi v-SNAREs
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