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Current · Arkansas
Last published
2021
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OpenAlex · ORCID
Refreshed
2026-10-06
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Anna Radomińska‐Pandya
High Impact
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Also affiliated: Boston University (2001); Tufts University (2008–2011); Centre National de la Recherche Scientifique (1999); Arkansas Children's Hospital (2011–2012); Salk Institute for Biological Studies (2001–2003); University of Helsinki (2006–2014); Howard Hughes Medical Institute (2001–2003); Eastern Virginia Medical School (2006); Gdańsk University of Technology (2012); University of Pittsburgh (2003); Washington University in St. Louis (2009); University of Michigan (2012); University of Arkansas Medical Center (2008–2021); University of Alabama at Birmingham (2000); University of California San Diego (2003); Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (1999); Cayman Chemical (United States) (2012); Michigan Medicine (2012); Arkansas State Crime Laboratory (2011–2012); Arkansas Department of Health (2009–2012); Institut National de la Recherche Agronomique (1999); Université Paul Verlaine - Metz (2006); Université Henri Poincaré (1999)
41 h-index
123 pubs
6,149 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Anna Radomińska‐Pandya's research focuses on the metabolic pathways of drugs and xenobiotics, particularly the role of UDP-glucuronosyltransferases (UGTs) and nuclear receptors in detoxification processes. Her work has investigated the structural and functional aspects of UGT enzymes, including the crystal structure of the cofactor-binding domain of human UGT2B7. She has also explored the involvement of nuclear receptors like SXR/PXR and CAR in the metabolism of various compounds, such as cholestatic bile acids and carcinogens.
More recently, her research has extended to the metabolism and toxicity of synthetic cannabinoids found in products like K2/Spice. This work includes characterizing the cytochrome P450-mediated oxidative metabolism of these compounds and identifying novel cannabinoid receptor ligands. Radomińska‐Pandya has also examined human PXR variants and their differential effects on UGT gene expression, contributing to the understanding of inter-individual variability in drug metabolism.
Her scholarly contributions are reflected in a high-impact research profile, evidenced by an h-index of 41, over 119 total publications, and more than 6,100 citations. She has collaborated with researchers at the University of Arkansas for Medical Sciences, including Alicja Urbaniak, Paul L. Prather, Amal Shoeib, and Azure L. Yarbrough.
Metrics
- h-index: 41
- Publications: 123
- Citations: 6,149
Selected Publications
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Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development (2021)
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Natural and Synthetic Cannabinoids Reduce Cell Viability of Ewing Sarcoma TC‐71 Cells Potentially via Non‐canonical CB receptors (2021)
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Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics (2020)
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Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity (2020)
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Identifying cytochrome P450s involved in oxidative metabolism of synthetic cannabinoid N‐(adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS‐135) (2020)
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Oxidative Metabolism and Comparative Analysis of Synthetic Cannabinoid N‐(1‐adamantyl)‐1‐(5‐fluoropentyl)indazole‐3‐carboxamide (5F‐AKB‐48) and the Unfluorinated Analog AKB‐48 (2019)
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Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22) (2019)
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Oxidative metabolism of synthetic cannabinoid STS-135 by recombinant P450S and human liver microsomes (2019)
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Natural compounds activating cannabinoid receptors CB1 and CB2: future for cancer treatments (2018)Acta Biochimica Polonica OpenAlex
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Convulsant Effects of Abused Synthetic Cannabinoids JWH-018 and 5F-AB-PINACA Are Mediated by Agonist Actions at CB1 Receptors in Mice (2018)
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Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to Δ9-THC (2018)
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Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants (2018)
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Biological Activity of Resveratrol‐Hydroxycinnamic Acid Ester Conjugates (2017)
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Identification of Novel Variants of the CB 1 Cannabinoid Receptor in Cancer Cells (2017)
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Synthetic Cannabinoids: Rapidly Emerging Drugs of Abuse (2017)
Collaboration Network
Top Collaborators
Stacie M. Bratton
University of Arkansas for Medical Sciences (US)
24 shared publications
- Crystal Structure of the Cofactor-Binding Domain of the Human Phase II Drug-Metabolism Enzyme UDP-Glucuronosyltransferase 2B7
- Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
- Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
- Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
- The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families
Showing 5 of 24 shared publications
Paul L. Prather
University of Arkansas for Medical Sciences
24 shared publications
In database
- Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: Mechanism underlying greater toxicity?
- Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
- Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
- Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine
- Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity
Showing 5 of 24 shared publications
Moshe Finel
University of Helsinki (FI)
16 shared publications
- Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
- Human UDP-Glucuronosyltransferase 1A5: Identification, Expression, and Activity
- Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases
- Dopamine Is a Low-Affinity and High-Specificity Substrate for the Human UDP-Glucuronosyltransferase 1A10
- Glucuronidation of Monohydroxylated Warfarin Metabolites by Human Liver Microsomes and Human Recombinant UDP-Glucuronosyltransferases
Showing 5 of 16 shared publications
William E. Fantegrossi
University of Arkansas for Medical Sciences
16 shared publications
In database
- Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: Mechanism underlying greater toxicity?
- Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine
- Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
Showing 5 of 16 shared publications
Jeffery H. Moran
16 shared publications
In database
- Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: Mechanism underlying greater toxicity?
- Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
- Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
- Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine
- Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity
Showing 5 of 16 shared publications
Joanna M. Little
University of Arkansas for Medical Sciences (US)
16 shared publications
- STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*
- Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism
- UDP-glucuronosyltransferases in human intestinal mucosa
- Direct Interaction of All-trans-retinoic Acid with Protein Kinase C (PKC)
- A Historical Overview of the Heterologous Expression of Mammalian UDP-Glucuronosyltransferase Isoforms Over the Past Twenty Years
Showing 5 of 16 shared publications
Laura P. James
University of Arkansas for Medical Sciences
10 shared publications
In database
- Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
- Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure
- Solid-Phase Extraction and Quantitative Measurement of Omega and Omega-1 Metabolites of JWH-018 and JWH-073 in Human Urine
Showing 5 of 10 shared publications
Azure L. Yarbrough
University of Arkansas for Medical Sciences
10 shared publications
In database
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
- Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to Δ9-THC
- Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity
- Identifying cytochrome P450s involved in oxidative metabolism of synthetic cannabinoid N‐(adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS‐135)
- Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development
Showing 5 of 10 shared publications
Grover P. Miller
University of Arkansas for Medical Sciences
9 shared publications
In database
- Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
- Assessing Cytochrome P450 and UDP-Glucuronosyltransferase Contributions to Warfarin Metabolism in Humans
- Glucuronidation of Monohydroxylated Warfarin Metabolites by Human Liver Microsomes and Human Recombinant UDP-Glucuronosyltransferases
- CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling
- The First Aspartic Acid of the DQxD Motif for Human UDP-Glucuronosyltransferase 1A10 Interacts with UDP-Glucuronic Acid during Catalysis
Showing 5 of 9 shared publications
Athena Starlard‐Davenport
University of Arkansas for Medical Sciences (US)
8 shared publications
- Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues
- Phenylalanine90 and phenylalanine93 are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10
- Novel identification of UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene
- A Potential Role for Human UDP-Glucuronosyltransferase 1A4 Promoter Single Nucleotide Polymorphisms in the Pharmacogenomics of Tamoxifen and Its Derivatives
- Erratum to “Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues” [Steroids 73 (6) (2008) 611–620]
Showing 5 of 8 shared publications
Guangping Chen
University of Arkansas for Medical Sciences (US)
8 shared publications
- 4-Hydroxyretinoic Acid, a Novel Substrate for Human Liver Microsomal UDP-glucuronosyltransferase(s) and Recombinant UGT2B7
- Direct Interaction of All-trans-retinoic Acid with Protein Kinase C (PKC)
- Human gastrointestinal sulfotransferases: identification and distribution☆
- Sulfation of the Isoflavones Genistein and Daidzein in Human and Rat Liver and Gastrointestinal Tract
- Photoaffinity Labeling of Human Retinoid X Receptor β (RXRβ) with 9-cis-Retinoic Acid: Identification of Phytanic Acid, Docosahexaenoic Acid, and Lithocholic Acid as Ligands for RXRβ
Showing 5 of 8 shared publications
Kathryn A. Seely
Arkansas Department of Health (US)
7 shared publications
- Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
- Forensic investigation of K2, Spice, and “bath salt” commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
- A Major Glucuronidated Metabolite of JWH-018 Is a Neutral Antagonist at CB1 Receptors
- Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors
- Targeted Metabolomic Approach for Assessing Human Synthetic Cannabinoid Exposure and Pharmacology
Showing 5 of 7 shared publications
Jacques Magdalou
École Nationale Vétérinaire de Toulouse (FR)
7 shared publications
- Resveratrol is efficiently glucuronidated by UDP‐glucuronosyltransferases in the human gastrointestinal tract and in Caco‐2 cells
- Structure of UDP‐Glucuronosyltransferases in Membranes
- Human and Rat Liver UDP-Glucuronosyltransferases Are Targets of Ketoprofen Acylglucuronide
- Glucuronidation of catechols by human hepatic, gastric, and intestinal microsomal UDP-glucuronosyltransferases (UGT) and recombinant UGT1A6, UGT1A9, and UGT2B7
- Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract
Showing 5 of 7 shared publications
Peter I. Mackenzie
Flinders University (AU)
7 shared publications
- STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*
- HUMAN PXR VARIANTS AND THEIR DIFFERENTIAL EFFECTS ON THE REGULATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE GENE EXPRESSION
- Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7
- 4-Hydroxyretinoic Acid, a Novel Substrate for Human Liver Microsomal UDP-glucuronosyltransferase(s) and Recombinant UGT2B7
- Human UDP-Glucuronosyltransferase 1A5: Identification, Expression, and Activity
Showing 5 of 7 shared publications
Ryoichi Fujiwara
University of Arkansas for Medical Sciences (US)
7 shared publications
- Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
- Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to Δ9-THC
- Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity
- Identifying cytochrome P450s involved in oxidative metabolism of synthetic cannabinoid N‐(adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS‐135)
- Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22)
Showing 5 of 7 shared publications
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