Arundhati Chavan

Researcher

University of Arkansas for Medical Sciences

unknown

4 pubs

Research Areas

Acute Myeloid Leukemia Research Epigenetics and DNA Methylation Cancer-related molecular mechanisms research Genomics and Phylogenetic Studies Child and Adolescent Health

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OverviewAI-generated summary

Arundhati Chavan's research investigates the molecular mechanisms underlying pediatric acute megakaryoblastic leukemia (AML). Her work focuses on how specific genetic fusions, such as the CBFA2T3-GLIS2 fusion, reprogram cellular processes. She has published research on how this fusion influences enhancer-linked DNA methylation, contributing to the enforcement of apoptotic resistance in AML cells. This reprogramming highlights a potential epigenetic vulnerability in the disease. Chavan's publications also explore transcriptional rewiring driven by enhancer methylation in pediatric AML, further detailing the epigenetic landscape of this aggressive cancer. She collaborates with researchers at the University of Arkansas for Medical Sciences, including Samrat Roy Choudhury and Giselle Almeida Gonzalez.

Metrics

  • Publications: 4

Selected Publications

  • Abstract PR006: CBFA2T3–GLIS2 fusion reprograms enhancer-linked DNA methylation to enforce apoptotic resistance and defines an epigenetic vulnerability in pediatric AML (2026) DOI
  • Transcriptional rewiring by enhancer methylation in CBFA2T3-GLIS2–driven pediatric acute megakaryoblastic leukemia (2025) DOI

Collaborators

Researchers in the database who share publications

Samrat Roy Choudhury University of Arkansas for Medical Sciences 2 shared publications Giselle Almeida Gonzalez University of Arkansas for Medical Sciences 2 shared publications Akhilesh Kaushal University of Arkansas for Medical Sciences 1 shared publication Pritam Biswas University of Arkansas for Medical Sciences 1 shared publication

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