B
Brian M. Varisco
Professor, Vice Chair for Research
faculty
COM | Peds Critical Care
18 h-index
91 pubs
1,260 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Brian M. Varisco is a Professor and Vice Chair for Research in Pediatric Critical Care at the University of Arkansas for Medical Sciences. His research focuses on understanding the mechanisms of lung injury and repair, particularly in the context of acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. He utilizes animal models, including mice and mouse lung organoids, to investigate cellular and molecular responses to various conditions, such as mechanical ventilation and fetal tracheal occlusion.
Dr. Varisco's work also extends to identifying biomarkers for critical illness, including pediatric sepsis and multi-organ dysfunction syndrome, employing machine learning approaches. He has published 91 papers, with an h-index of 18 and over 1,200 citations. His collaborators include James Williams, A. Edwards, Craig Porter, and Matthew Frazier, all from the University of Arkansas for Medical Sciences.
Metrics
- h-index: 18
- Publications: 91
- Citations: 1,260
Selected Publications
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Methylomic Analysis of Nasal Brushings Reveals Two Subgroups in Pediatric Acute Respiratory Distress Syndrome (2026)
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Novel murine partial tracheal occlusion model with altered respiratory dynamics (2025)
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Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development (2025)
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444 scRNA seq analysis of lower respiratory tract immune cells to uncover immuno-endotypes in SA-PARDS (2025)
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YAP Deficiency Drives NF-κB Hyperactivation to Disrupt Airway Epithelium Differentiation in Congenital Diaphragmatic Hernia (2024)
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Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia (2024)
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KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency (2024)
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Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development (2024)
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KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency (2024)
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Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome (2024)
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Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling (2024)
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A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase (2023)
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Developing a mechanistic understanding of pediatric acute respiratory distress syndrome one cell at a time (2023)
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Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency (2023)
Grants & Funding
- Chymotrypsin-like Elastase 1 in Lung Development and Disease NIH Principal Investigator
- FASEB SRC on The Lung Epithelium in Health and Disease NIH Principal Investigator
- Cela1 Mediates Stretch-regulated Elastin Remodeling During Alveolar Septation NIH Principal Investigator
Collaboration Network
Top Collaborators
Rashika Joshi
University of Cincinnati (US)
17 shared publications
- Mouse lung organoid responses to reduced, increased, and cyclic stretch
- Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- Multi-omic characterization of pediatric ARDS via nasal brushings
Showing 5 of 17 shared publications
Nadir Yehya
Children's Hospital of Philadelphia (US)
9 shared publications
- Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome
- Biomarker-Based Risk Stratification in Pediatric Sepsis From a Low-Middle Income Country*
- Comparison of 16 Pediatric Acute Respiratory Distress Syndrome-Associated Plasma Biomarkers With Changing Lung Injury Severity*
- 28: BIOMARKER-BASED RISK STRATIFICATION IN PEDIATRIC SEPSIS FROM A LOW-MIDDLE-INCOME COUNTRY
- Biomarker-Based Risk Stratification Tool in Pediatric Acute Respiratory Distress Syndrome: Single-Center, Longitudinal Validation in a 2014–2019 Cohort
Showing 5 of 9 shared publications
Noah J. Smith
University of Cincinnati Medical Center (US)
8 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase
- CELA1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
Showing 5 of 8 shared publications
José L. Peiró
University of Cincinnati Medical Center (US)
7 shared publications
- Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling
- Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia
- Transuterine Fetal Tracheal Occlusion Model in Mice
- Murine Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling
- YAP Deficiency Drives NF-κB Hyperactivation to Disrupt Airway Epithelium Differentiation in Congenital Diaphragmatic Hernia
Showing 5 of 7 shared publications
James Williams
University of Arkansas for Medical Sciences (US)
7 shared publications
- Comparison of 16 Pediatric Acute Respiratory Distress Syndrome-Associated Plasma Biomarkers With Changing Lung Injury Severity*
- Multi-omic characterization of pediatric ARDS via nasal brushings
- Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction
- Multi-Omic Profiling of Nasal Brushings Pediatric ARDS Identifies Patterns of Injury, Repair, and Recovery
- Multi-omic Characterization of Pediatric ARDS via Nasal Brushings
Showing 5 of 7 shared publications
Patrick Lahni
Cincinnati Children's Hospital Medical Center (US)
7 shared publications
- Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome
- Biomarker-Based Risk Stratification in Pediatric Sepsis From a Low-Middle Income Country*
- Comparison of 16 Pediatric Acute Respiratory Distress Syndrome-Associated Plasma Biomarkers With Changing Lung Injury Severity*
- 28: BIOMARKER-BASED RISK STRATIFICATION IN PEDIATRIC SEPSIS FROM A LOW-MIDDLE-INCOME COUNTRY
- Multi-omic characterization of pediatric ARDS via nasal brushings
Showing 5 of 7 shared publications
Andrew J. Devine
Ohio University (US)
6 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase
- CELA1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
Showing 5 of 6 shared publications
Mario Marotta
Universitat Autònoma de Barcelona (ES)
5 shared publications
- Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling
- Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia
- Murine Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling
- YAP Deficiency Drives NF-κB Hyperactivation to Disrupt Airway Epithelium Differentiation in Congenital Diaphragmatic Hernia
- Defective Mechanotransduction in Congenital Diaphragmatic Hernia Impairs Airway Epithelial Cell Differentiation
Emrah Aydın
Cincinnati Children's Hospital Medical Center (US)
4 shared publications
- Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling
- Transuterine Fetal Tracheal Occlusion Model in Mice
- Murine Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling
- Transuterine Fetal Tracheal Occlusion Model in Mice
Marc Oria
University of Cincinnati Medical Center (US)
4 shared publications
- Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling
- Transuterine Fetal Tracheal Occlusion Model in Mice
- Murine Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling
- Transuterine Fetal Tracheal Occlusion Model in Mice
Qiang Fan
Cincinnati Children's Hospital Medical Center (US)
4 shared publications
- Mouse lung organoid responses to reduced, increased, and cyclic stretch
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- CELA1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
Rhonda Jones
Cincinnati Children's Hospital Medical Center (US)
4 shared publications
- Comparison of 16 Pediatric Acute Respiratory Distress Syndrome-Associated Plasma Biomarkers With Changing Lung Injury Severity*
- Multi-omic characterization of pediatric ARDS via nasal brushings
- Multi-Omic Profiling of Nasal Brushings Pediatric ARDS Identifies Patterns of Injury, Repair, and Recovery
- Multi-omic Characterization of Pediatric ARDS via Nasal Brushings
Mihir R. Atreya
4 shared publications
- Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness
- Machine learning driven identification of gene-expression signatures correlated with multiple organ dysfunction trajectories and complex sub-endotypes of pediatric septic shock
- Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction
- 891: ENDOTHELIAL BIOMARKERS PREDICT PERSISTENT PEDIATRIC SEPSIS-ASSOCIATED ACUTE RESPIRATORY DYSFUNCTION
Hector R. Wong
University of Cincinnati Medical Center (US)
3 shared publications
- Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness
- Multi-omic characterization of pediatric ARDS via nasal brushings
- Machine learning driven identification of gene-expression signatures correlated with multiple organ dysfunction trajectories and complex sub-endotypes of pediatric septic shock
Jane Whitney
3 shared publications
- Biomarker-Based Risk Stratification Tool in Pediatric Acute Respiratory Distress Syndrome: Single-Center, Longitudinal Validation in a 2014–2019 Cohort
- Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction
- 713: LONGITUDINAL VALIDATION OF A BIOMARKER-BASED RISK STRATIFICATION TOOL FOR PEDIATRIC ARDS
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