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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
B
Brian Michael Varisco
Professor, Vice Chair for Research
Also affiliated: Northwestern University (2022); Cincinnati Children's Hospital Medical Center (2011–2024); Arkansas Children's Hospital (2023); Nationwide Children's Hospital (2022); Emory University (2022); Indian Institute of Technology Madras (2022); Augusta University (2004); University of Alabama at Birmingham (2009–2010); Ohio University (2024); UAB Medicine (2010); Arkansas Children's Research Institute (2023–2026); University of Cincinnati (2011–2024); University of Cincinnati Medical Center (2014)
COM | Peds Critical Care
18 h-index
95 pubs
1,315 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Brian Michael Varisco's research focuses on lung biology and disease, including pulmonary fibrosis and acute lung injury in sepsis. He investigates the mechanisms regulating epithelial transitional states in both murine and human lung tissue, with a particular interest in the role of epigenetic modifications, such as histone deacetylase inhibitors, in lung fibroblast differentiation. His work also explores signaling pathways, including Thy-1 and PPARγ, that influence lipofibroblast differentiation and vascular development in the developing lung.
Varisco has also contributed to the understanding of pediatric critical care through simulation-based education. His scholarship metrics include an h-index of 18, with 92 total publications and 1,316 citations. He has collaborated with researchers at the University of Arkansas for Medical Sciences, including James W. Williams, Emily Goodman, and A. Edwards.
Metrics
- h-index: 18
- Publications: 95
- Citations: 1,315
Positions
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Professor, Vice Chair for Research 2023–presentUniversity of Arkansas for Medical Sciences COM | Peds Critical Care Institutional directory
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Director of Laboratory Research 2023–presentArkansas Children's Hospital ORCID
Selected Publications
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Lung ultrasound feature tracking to quantify regional lung strain in mechanically ventilated pigs (2026)
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Cytokine-based strategies to improve prognostic enrichment of pediatric ARDS (2026)
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419 Sepsis-associated PARDS is associated with an exhausted neutrophil phenotype in the lower respiratory tract (2026)
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Lung Ultrasound Feature Tracking to Quantify Regional Lung Strain in Mechanically Ventilated Pigs (2026)
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Development and testing of a novel point-of-care ultrasound based tool for quantifying local lung tissue strain (2026)
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Increased transpulmonary pressure from partial tracheal occlusion potentiates tissue destruction in a mouse model of emphysema (2026)
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Methylomic Analysis of Nasal Brushings Reveals Two Subgroups in Pediatric Acute Respiratory Distress Syndrome (2026)
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Novel murine partial tracheal occlusion model with altered respiratory dynamics (2025)
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Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development (2025)
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444 scRNA seq analysis of lower respiratory tract immune cells to uncover immuno-endotypes in SA-PARDS (2025)
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YAP Deficiency Drives NF-κB Hyperactivation to Disrupt Airway Epithelium Differentiation in Congenital Diaphragmatic Hernia (2024)
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Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction (2024)
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Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia (2024)
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KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency (2024)
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Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Chymotrypsin-like Elastase 1 in Lung Development and Disease NIH Principal Investigator
- FASEB SRC on The Lung Epithelium in Health and Disease NIH Principal Investigator
- Cela1 Mediates Stretch-regulated Elastin Remodeling During Alveolar Septation NIH Principal Investigator
Collaboration Network
Top Collaborators
Rashika Joshi
Cincinnati Children's Hospital Medical Center (US)
9 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
Showing 5 of 9 shared publications
Noah J. Smith
University of Cincinnati (US)
7 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
Showing 5 of 7 shared publications
Andrew J. Devine
Ohio University (US)
5 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency
James Williams
Arkansas Children's Hospital
5 shared publications
In database
- Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction
- Developing a mechanistic understanding of pediatric acute respiratory distress syndrome one cell at a time
- Methylomic Analysis of Nasal Brushings Reveals Two Subgroups in Pediatric Acute Respiratory Distress Syndrome
- Lung Ultrasound Feature Tracking to Quantify Regional Lung Strain in Mechanically Ventilated Pigs
- Lung ultrasound feature tracking to quantify regional lung strain in mechanically ventilated pigs
Emily Goodman
University of Arkansas for Medical Sciences
3 shared publications
In database
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency
Jerilyn K. Gray
Cincinnati Children's Hospital Medical Center (US)
3 shared publications
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
- Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
Basilia Zingarelli
Cincinnati Children's Hospital Medical Center (US)
3 shared publications
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency
- Novel murine partial tracheal occlusion model with altered respiratory dynamics
A. Edwards
University of Arkansas for Medical Sciences
3 shared publications
In database
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
- Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
- Novel murine partial tracheal occlusion model with altered respiratory dynamics
Elham Shahreki
Geisinger Medical Center
3 shared publications
In database
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
- Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
- Novel murine partial tracheal occlusion model with altered respiratory dynamics
Qiang Fan
Cincinnati Children's Hospital Medical Center (US)
2 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
Michael T. Borchers
University of Cincinnati (US)
2 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
Hitesh Deshmukh
Cincinnati Children's Hospital Medical Center (US)
2 shared publications
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
Nadir Yehya
Children's Hospital of Philadelphia (US)
2 shared publications
- Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome
- Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction
Daniel McKeone
Penn State Milton S. Hershey Medical Center (US)
2 shared publications
- Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome
- Cytokine-based strategies to improve prognostic enrichment of pediatric ARDS
E. Scott Halstead
Penn State Milton S. Hershey Medical Center (US)
2 shared publications
- Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome
- Cytokine-based strategies to improve prognostic enrichment of pediatric ARDS
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