B
Brian Storrie
Federal Grant PI
High Impact
Professor
faculty
Physiology & Cell Biology, College of Medicine
44 h-index
183 pubs
6,598 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Brian Storrie is a Professor in the Department of Physiology & Cell Biology at the University of Arkansas for Medical Sciences. His research program focuses on the cellular mechanisms underlying platelet function, particularly in the context of hemostasis and thrombosis. He investigates how platelets are activated, aggregate, and release their granular contents to form thrombi at sites of vascular injury.
Dr. Storrie has received federal funding from the NIH/National Heart Lung and Blood Institute for his work on the structure and function determinants of puncture wound thrombus formation, totaling $624,823. His laboratory utilizes advanced techniques, including 3D electron microscopy and deep learning for ultrastructural analysis, to quantify cellular and organelle packing in platelets. Recent studies have explored the impact of specific proteins, such as serglycin, on platelet cargo packaging and release, and have examined platelet behavior in the context of COVID-19 infection. His work also extends to developing mouse models to study genetic disorders affecting protein glycosylation and bone resorption.
With an h-index of 44 and over 183 publications, Dr. Storrie has a well-established record of research productivity. He actively collaborates with colleagues at the University of Arkansas for Medical Sciences, including Irina D. Pokrovskaya, Kelly K. Ball, Sung W. Rhee, and Michael W. Webb.
Metrics
- h-index: 44
- Publications: 183
- Citations: 6,598
Selected Publications
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Murine Thrombus Organization Limits Access to High Platelet Activation States While Supporting Platelet Recruitment (2026)
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BPS2026 – Machine learning analysis of cellular remodeling during occlusive blood clot formation (2026)
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The Syk inhibitor BI 1002494 impairs thrombus infill in a murine femoral artery occlusion without affecting hemostasis (2025)
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Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets (2025)
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Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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BPS2025 - Machine vision pipeline to elucidate structural underpinnings of blood clot formation (2025)
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Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)
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Differential Effects of GPVI Deletion and SYK Inhibition on Thrombus Organization and Platelet Adhesion in a Murine Jugular Puncture Wound Model (2024)
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Densely Populated Cell and Organelles Segmentation with U-Net Ensembles (2024)
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Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation (2024)
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Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis (2024)
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JoVE Video Dataset (2024)
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Trained image analysis techniques for characterizing cell phenotype in electron microscopy images of mouse thrombi (2024)
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Screening for Key Structural Differences in Thrombosis Versus Hemostasis through Single Platelet Analysis (2023)
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OC 61.4 Manipulating Platelet Secretion to Affect Hemostasis (2023)
Federal Grants 1 $624,823 total
NIH/National Heart Lung and Blood Institute
Contact PI
Sep 2021 - Aug 2025
Resubmission: Structure/Function Determinants of Puncture Wound Thrombus Formation
Research Interests
Research search concentrates on how platelet secretion and aggregation properties structure thrombus formation asd provide structure based therapeutic targets. Much of the research uses volume electronn microscopy as a 3D structural approach to puncture wound thrombi and occlusive clots. Mechanism is approached through the use of mouse genetic knockouts and inhibitory drugs of clinical significance.
Grants & Funding
- 120 kV FEI Electron Microscope and Supporting Sample Preparation Equipment for Biological Microscopy National Science Foundation Principal Investigator
- Platelet Exocytosis and Endocytosis in Thrombosis and Immunity NIH/Nat. Heart, Lung & Blood Institute - Pass Through: University of Kentucky Research Foundation Principal Investigator
- STRUCTURAL ORGANIZATION OF THE MAMMALIAN GOLGI COMPLEX NIH Principal Investigator
- Structural, Functional,and Molecular Characterization of Platelet alpha-Granule Subpopulations American Heart Association (Midwest Affiliate) Principal Investigator
- Platelet Exocytosis and Endocytosis in Thrombosis and Immunity NIH/Nat. Heart, Lung & Blood Institute - Pass Through: University of Kentucky Research Foundation Principal Investigator
- No FP attached UAMS College of Medicine Principal Investigator
- Storrie EM NSF COM Commitment Acct UAMS College of Medicine Principal Investigator
- Mechanisms of Golgi Apparatus Protein Recycling NIH Principal Investigator
Collaboration Network
Top Collaborators
Irina D. Pokrovskaya
University of Arkansas for Medical Sciences
28 shared publications
In database
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
Showing 5 of 28 shared publications
Richard D. Leapman
National Institute of Biomedical Imaging and Bioengineering (US)
18 shared publications
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
Showing 5 of 18 shared publications
Maria A. Aronova
National Institute of Biomedical Imaging and Bioengineering (US)
17 shared publications
- Dense cellular segmentation for EM using 2D–3D neural network ensembles
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
Showing 5 of 17 shared publications
Kelly K. Ball
University of Arkansas for Medical Sciences
12 shared publications
In database
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
Showing 5 of 12 shared publications
Sung W. Rhee
University of Arkansas for Medical Sciences
10 shared publications
In database
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
Showing 5 of 10 shared publications
Sidney W. Whiteheart
University of Kentucky (US)
9 shared publications
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
- OC 61.4 Manipulating Platelet Secretion to Affect Hemostasis
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
Showing 5 of 9 shared publications
Smita Joshi
University of Kentucky (US)
8 shared publications
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
- OC 61.4 Manipulating Platelet Secretion to Affect Hemostasis
- Theme and Variation: Structuring Thrombus Formation from Jugular/Arterial Puncture Wounds to Occlusive Clots in a Mouse Model
Showing 5 of 8 shared publications
Jeffrey A. Kamykowski
University of Arkansas for Medical Sciences
8 shared publications
In database
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Electron Microscope Characterization of Platelet Activation State Reveals That Wound Closure and P2Y 12 Receptors Are Major Early Determinants of Thrombus Structure in a Venous Puncture Model
- Trained image analysis techniques for characterizing cell phenotype in electron microscopy images of mouse thrombi
Showing 5 of 8 shared publications
Michael W. Webb
University of Arkansas for Medical Sciences
8 shared publications
In database
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
- Theme and Variation: Structuring Thrombus Formation from Jugular/Arterial Puncture Wounds to Occlusive Clots in a Mouse Model
- Screening for Key Structural Differences in Thrombosis Versus Hemostasis through Single Platelet Analysis
- Differential Effects of GPVI Deletion and SYK Inhibition on Thrombus Organization and Platelet Adhesion in a Murine Jugular Puncture Wound Model
- Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure
Showing 5 of 8 shared publications
D. Cruz
7 shared publications
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Quantitative analysis with deep learning segmentation and modeling of 3D electron microscopy data
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
Showing 5 of 7 shared publications
Douglas J. Palumbo
5 shared publications
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Quantitative analysis with deep learning segmentation and modeling of 3D electron microscopy data
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
- Combined use of serial block face SEM and focused ion beam SEM elucidates the 3D ultrastructure of blood platelets and thrombi
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
Rahul R. Akkem
5 shared publications
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Quantitative analysis with deep learning segmentation and modeling of 3D electron microscopy data
- Comparison of Ultrastructure Determined by Serial Block Face SEM and Focused Ion Beam SEM from Blood Platelets and Thrombi
- Combined use of serial block face SEM and focused ion beam SEM elucidates the 3D ultrastructure of blood platelets and thrombi
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
Hammodah R. Alfar
University of Kentucky (US)
5 shared publications
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
- OC 61.4 Manipulating Platelet Secretion to Affect Hemostasis
- Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets
- Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets
Oliver Zhao
4 shared publications
- Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates
- Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site
- Single-Platelet Mapping of Jugular, Puncture-Wound Thrombi Reveals the Spatial Evolution of Platelet Activation
- Differential Platelet Spatial Morphodynamics in Response to Local Signaling Environments Within a Jugular Puncture Wound Thrombus
Harry Chanzu
University of Kentucky (US)
3 shared publications
- Platelet α‐granule cargo packaging and release are affected by the luminal proteoglycan, serglycin
- OC 61.4 Manipulating Platelet Secretion to Affect Hemostasis
- Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets
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