Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
B
Brian M. Varisco
Professor, Vice Chair for Research
Also affiliated: Cincinnati Children's Hospital Medical Center (2011–2024); Arkansas Children's Hospital (2023–2026); Nationwide Children's Hospital (2022); Pacific Northwest National Laboratory (2023); Emory University (2022); Indian Institute of Technology Madras (2022); Augusta University (2004); Hospital Research Foundation (2014–2023); University of Alabama at Birmingham (2009–2010); Ohio University (2024); Pulmonary Associates (2010); Arkansas Children's Nutrition Center (2025–2026); The Royal Children's Hospital Foundation (2022); University of Cincinnati (2011–2023); University of Cincinnati Medical Center (2013–2024)
Faculty Researcher
COM | Peds Critical Care
18 h-index
92 pubs
1,303 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Brian M. Varisco investigates mechanisms of lung injury and repair, with a focus on pediatric acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. His research utilizes both murine models and human samples to explore epithelial cell dynamics and inflammatory responses. Recent work has examined the role of gene expression signatures in predicting organ dysfunction trajectories in critical illness and has explored the potential of machine learning for identifying these signatures.
Varisco's work also extends to understanding biomarker utility in pediatric critical care settings, including sepsis and ARDS, particularly in low-middle income country contexts. He has investigated how factors such as mechanical stretch influence lung development and cellular responses, using lung organoid models. His research network includes collaborators within the University of Arkansas for Medical Sciences, with whom he has co-authored multiple publications.
Metrics
- h-index: 18
- Publications: 92
- Citations: 1,303
Selected Publications
-
Lung ultrasound feature tracking to quantify regional lung strain in mechanically ventilated pigs (2026)
-
Cytokine-based strategies to improve prognostic enrichment of pediatric ARDS (2026)
-
419 Sepsis-associated PARDS is associated with an exhausted neutrophil phenotype in the lower respiratory tract (2026)
-
Lung Ultrasound Feature Tracking to Quantify Regional Lung Strain in Mechanically Ventilated Pigs (2026)
-
Development and testing of a novel point-of-care ultrasound based tool for quantifying local lung tissue strain (2026)
-
Increased transpulmonary pressure from partial tracheal occlusion potentiates tissue destruction in a mouse model of emphysema (2026)
-
Methylomic Analysis of Nasal Brushings Reveals Two Subgroups in Pediatric Acute Respiratory Distress Syndrome (2026)
-
Novel murine partial tracheal occlusion model with altered respiratory dynamics (2025)
-
Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development (2025)
-
444 scRNA seq analysis of lower respiratory tract immune cells to uncover immuno-endotypes in SA-PARDS (2025)
-
YAP Deficiency Drives NF-κB Hyperactivation to Disrupt Airway Epithelium Differentiation in Congenital Diaphragmatic Hernia (2024)
-
Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction (2024)
-
Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia (2024)
-
KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency (2024)
-
Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Chymotrypsin-like Elastase 1 in Lung Development and Disease NIH Principal Investigator
- FASEB SRC on The Lung Epithelium in Health and Disease NIH Principal Investigator
- Cela1 Mediates Stretch-regulated Elastin Remodeling During Alveolar Septation NIH Principal Investigator
Collaboration Network
Top Collaborators
Rashika Joshi
Cincinnati Children's Hospital Medical Center (US)
9 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
Showing 5 of 9 shared publications
Noah J. Smith
University of Cincinnati Medical Center (US)
7 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
Showing 5 of 7 shared publications
Andrew J. Devine
Ohio University (US)
5 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency
Emily Goodman
University of Arkansas for Medical Sciences
3 shared publications
In database
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency
Jerilyn K. Gray
Cincinnati Children's Hospital Medical Center (US)
3 shared publications
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
- Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
Basilia Zingarelli
Cincinnati Children's Hospital Medical Center (US)
3 shared publications
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency
- Novel murine partial tracheal occlusion model with altered respiratory dynamics
A. Edwards
University of Arkansas for Medical Sciences
3 shared publications
In database
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
- Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
- Novel murine partial tracheal occlusion model with altered respiratory dynamics
Qiang Fan
Cincinnati Children's Hospital Medical Center (US)
2 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
Michael T. Borchers
University of Cincinnati Medical Center (US)
2 shared publications
- Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
James Williams
University of Arkansas for Medical Sciences
2 shared publications
In database
- Developing a mechanistic understanding of pediatric acute respiratory distress syndrome one cell at a time
- Methylomic Analysis of Nasal Brushings Reveals Two Subgroups in Pediatric Acute Respiratory Distress Syndrome
Hitesh Deshmukh
Cincinnati Children's Hospital Medical Center (US)
2 shared publications
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling
- Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development
Patrick Lahni
Cincinnati Children's Hospital Medical Center (US)
2 shared publications
- Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome
- Methylomic Analysis of Nasal Brushings Reveals Two Subgroups in Pediatric Acute Respiratory Distress Syndrome
Brandon Brooks-Patton
Northern Kentucky University (US)
2 shared publications
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency
Jenna Dunham
Northern Kentucky University (US)
2 shared publications
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency
Ansley N. Varisco
University of Arkansas at Little Rock
2 shared publications
In database
- KF4 anti-CELA1 Antibody and Purified α1-Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine α1-Antitrypsin Deficiency
- KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency
Similar Researchers
Based on overlapping research topics
Garrett L Spears
University of Arkansas for Medical Sciences
Disease Models, Animal
Immune Response and Inflammation
Machine Learning Applications
Esther H. Teo
University of Arkansas for Medical Sciences
Disease Models, Animal
Immune Response and Inflammation
Child and Adolescent Health
Jia Di
University of Arkansas at Fayetteville
Disease Models, Animal
Immune Response and Inflammation
Machine Learning Applications
SYEDA SAMAR SOHAIL
University of Arkansas for Medical Sciences
Immune Response and Inflammation
Child and Adolescent Health
Disease Mechanisms Research
Tamara T. Perry
University of Arkansas for Medical Sciences
Immune Response and Inflammation
Child and Adolescent Health
Disease Mechanisms Research
Nicholas Callais
University of Arkansas for Medical Sciences
Disease Models, Animal
Immune Response and Inflammation
Machine Learning Applications