Ana Clara P. Azevedo‐Pouly

Researcher

University of Arkansas for Medical Sciences

faculty

13 h-index 35 pubs 742 cited

Research Areas

Immune Response and Inflammation T-cell and B-cell Immunology Pharmacological Effects and Toxicity Studies Cardiovascular Function and Risk Factors Cancer-related molecular mechanisms research DNA Repair Mechanisms

Links

ORCID Lab Website

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OverviewAI-generated summary

Ana Clara P. Azevedo‐Pouly's research investigates the molecular mechanisms underlying immune cell activation and function, with a particular focus on the DNA-PKcs kinase. Her work has explored how DNA-PKcs activity influences the stabilization of transcription factor Egr1 in activated immune cells, impacting both CD4+ helper and CD8+ effector T cells. Azevedo‐Pouly has also examined the role of this pathway in T cell signaling and cytotoxicity. In addition to immunology, her research extends to cardiovascular health, investigating the potential involvement of the apelin-APJ pathway in sex-related differential cardiotoxicity induced by doxorubicin in mice. She has also contributed to the discovery of novel inhibitors, such as DA-143, designed to improve solubility and efficacy compared to existing compounds. Her scholarship includes 35 publications, with an h-index of 13 and 742 total citations, and she collaborates with researchers at the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 13
  • Publications: 35
  • Citations: 742

Selected Publications

  • DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling (2025) DOI
  • DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells (2025) DOI
  • The use of DNAPK inhibitors increases the efficacy of Lentiviral vectors and decreases off-target effects. (2024) DOI
  • Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441 (2024) DOI
  • Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells (2023) DOI
  • DNA-PKcs is required for the activation and cytotoxicity of CD8+ effector T cells (2022) DOI
  • Potential role of the apelin‐APJ pathway in sex‐related differential cardiotoxicity induced by doxorubicin in mice (2022) DOI
  • Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia (2022) DOI
  • Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4 <sup>+</sup> helper and CD8 <sup>+</sup> effector T cells (2022) DOI
  • DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells (2021) DOI
  • DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells (2021) DOI

Collaborators

Researchers in the database who share publications

Randall R Rainwater University of Arkansas for Medical Sciences 6 shared publications Brian Koss University of Arkansas for Medical Sciences 4 shared publications Lauren Elizabeth Appell University of Arkansas for Medical Sciences 3 shared publications Melanie Barker University of Arkansas for Medical Sciences 3 shared publications Lauren C. Morehead University of Arkansas for Medical Sciences 2 shared publications Lora J. Rogers University of Arkansas for Medical Sciences 2 shared publications B.R. Hicks University of Arkansas for Medical Sciences 2 shared publications Samuel G. Mackintosh University of Arkansas for Medical Sciences 2 shared publications

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