Biography and Research Information
OverviewAI-generated summary
Javier R. Revollo is a research biologist whose work focuses on assessing the mutagenic and genotoxic effects of various chemical agents. He has published research utilizing advanced sequencing technologies, such as PacBio HiFi sequencing, to detect ultra-low-frequency mutations across the genome. His studies have investigated mutagens like Molnupiravir, N4-hydroxycytidine, and N-nitrosodimethylamine in both bacterial and mammalian cell systems, including HepaRG cells and mouse lymphoma L5178Y cells. Revollo also explores the application of long-read sequencing for in vivo chemical mutagenesis assessment and has investigated the potential role of specific cellular pathways in drug-induced cardiotoxicity in mice. His research network includes numerous collaborators from the National Center for Toxicological Research, with whom he has co-authored multiple publications. Revollo's scholarship metrics include an h-index of 16 and over 3,300 citations across 52 publications.
Metrics
- h-index: 16
- Publications: 52
- Citations: 3,377
Selected Publications
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Mutagenicity of <i>N</i> -nitroso-fluoxetine and <i>N</i> -nitroso-varenicline in human HepaRG cell models (2026)
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Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen (2025)
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Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing (2025)
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Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection (2024)
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Assessment of in vivo chemical mutagenesis by long-read sequencing (2024)
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Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp (2024)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo (2023)
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Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing (2023)
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Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp (2023)
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Detecting N-ethyl-N-nitrosourea-induced mutation in the tissues of mice using whole-genome HiFi Sequencing (2022)
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Potential role of the apelin‐APJ pathway in sex‐related differential cardiotoxicity induced by doxorubicin in mice (2022)
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Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing (2022)
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Draft Genome Sequences of Tetracycline-Resistant Shiga Toxin-Producing Escherichia coli Isolates from Food (2022)
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Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing (2022)
Collaboration Network
Top Collaborators
Jaime A. Miranda
National Center for Toxicological Research
12 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- <scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Assessment of in vivo chemical mutagenesis by long-read sequencing
Showing 5 of 12 shared publications
Page B. McKinzie
National Center for Toxicological Research
8 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
Showing 5 of 8 shared publications
Vasily N. Dobrovolsky
United States Food and Drug Administration
8 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- <scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
Showing 5 of 8 shared publications
Robert H. Heflich
United States Food and Drug Administration
3 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
Khulud Alotaibi
Saudi Arabian Monetary Authority
3 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of Tetracycline-Resistant Shiga Toxin-Producing Escherichia coli Isolates from Food
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
Ashraf A. Khan
United States Food and Drug Administration
3 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of Tetracycline-Resistant Shiga Toxin-Producing Escherichia coli Isolates from Food
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
Kidon Sung
National Center for Toxicological Research
3 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
- Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection
Saeed Khan
National Center for Toxicological Research
3 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
- Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection
Mohamed S. Nawaz
United States Food and Drug Administration (US)
3 shared publications
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
- Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection
Xiaoqing Guo
National Center for Toxicological Research
3 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
Azra Dad
National Center for Toxicological Research
2 shared publications
In database
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
- Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing
Timothy W. Robison
Center for Drug Evaluation and Research (US)
2 shared publications
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
J. Jaime Miranda
National Center for Toxicological Research (US)
2 shared publications
- Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo
- Detecting N-ethyl-N-nitrosourea-induced mutation in the tissues of mice using whole-genome HiFi Sequencing
Ji‐Eun Seo
National Center for Toxicological Research
2 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing
Miseon Park
National Center for Toxicological Research
2 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection
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