Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
J
Javier R. Revollo
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Research Biologist
Also affiliated: National Institutes of Health (2009–2013); United States Food and Drug Administration (2013–2026); Washington University in St. Louis (2004–2007); National Institute of Environmental Health Sciences (2009–2013)
16 h-index
52 pubs
3,588 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Javier R. Revollo is a research biologist at the National Center for Toxicological Research. His work focuses on evaluating the mutagenic effects of various substances using advanced sequencing technologies. Revollo has investigated the mutagenicity of compounds like Molnupiravir and N-nitrosodimethylamine in bacterial and mammalian cell cultures, employing high-fidelity (HiFi) sequencing and error-corrected next-generation sequencing for precise detection of mutations. His research also explores the genome-wide detection of ultralow-frequency substitution mutations, including those resulting from chemical mutagen exposure in mouse lymphoma cells and *Caenorhabditis elegans*. Revollo has published extensively on these topics, with a h-index of 16 and over 3,500 citations. He collaborates with several researchers at the National Center for Toxicological Research, including Jaime A. Miranda and Page B. McKinzie.
Metrics
- h-index: 16
- Publications: 52
- Citations: 3,588
Positions
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Research Biologist 2012–presentNational Center for Toxicological Research Division of Genetic and Molecular Toxicology ORCID
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National Institute of Environmental Health Sciences 2007–2012ORCID
Selected Publications
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Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids (2026)
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Mutagenicity of N -nitroso-fluoxetine and N -nitroso-varenicline in human HepaRG cell models (2026)
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Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen (2025)
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Background Mutation Frequencies in TK6 and L5178Y Cells: Implications for Error‐Corrected Sequencing (2025)
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Complete genome sequence of cephalosporin and tetracycline-resistant Citrobacter freundii CF51 isolate from a patient with urinary tract infection (2024)
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Assessment of in vivo chemical mutagenesis by long-read sequencing (2024)
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Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp (2024)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo (2023)
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Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by HiFi sequencing (2023)
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Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp (2023)
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Detecting N-ethyl-N-nitrosourea-induced mutation in the tissues of mice using whole-genome HiFi Sequencing (2022)
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Potential role of the apelin‐APJ pathway in sex‐related differential cardiotoxicity induced by doxorubicin in mice (2022)
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Evaluation of the mutagenic effects of Molnupiravir and N4 ‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing (2022)
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Draft Genome Sequences of Tetracycline-Resistant Shiga Toxin-Producing Escherichia coli Isolates from Food (2022)
Collaboration Network
Top Collaborators
Vasily N. Dobrovolsky
National Center for Toxicological Research
24 shared publications
In database
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- Evaluation of the mutagenic effects of Molnupiravir and N4 ‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing
- CD48‐deficient T‐lymphocytes from DMBA‐treated rats have de novo mutations in the endogenous Pig‐a gene
- Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine
- Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig‐a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/− cells and the CD90.2 antigen
Showing 5 of 24 shared publications
Page B. McKinzie
National Center for Toxicological Research
17 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and N4 ‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine
- Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig‐a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/− cells and the CD90.2 antigen
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
Showing 5 of 17 shared publications
Mason G. Pearce
National Center for Toxicological Research
13 shared publications
In database
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- CD48‐deficient T‐lymphocytes from DMBA‐treated rats have de novo mutations in the endogenous Pig‐a gene
- Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
Showing 5 of 13 shared publications
Jaime A. Miranda
National Center for Toxicological Research
13 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and N4 ‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- PacBio sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens
- Assessment of in vivo chemical mutagenesis by long-read sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma L5178Y cells and Caenorhabditis elegans worms by PacBio sequencing
Showing 5 of 13 shared publications
Robert H. Heflich
National Center for Toxicological Research
11 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
- In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
Showing 5 of 11 shared publications
Azra Dad
National Center for Toxicological Research
11 shared publications
In database
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
- Genome-wide mutation detection by interclonal genetic variation
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
- Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells
Showing 5 of 11 shared publications
Dayton M. Petibone
National Center for Toxicological Research
5 shared publications
In database
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines
- In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene
- Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells
- Analysis of mutation in the rat Pig‐a assay: II. Studies with bone marrow granulocytes
Timothy W. Robison
United States Food and Drug Administration (US)
5 shared publications
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells
- Pig-a mutations in bone marrow erythroblasts of rats treated with 7,12-dimethyl-benz[a]anthracene
- CD59 ‐deficient bone marrow erythroid cells from rats treated with procarbazine and propyl‐nitrosourea have mutations in thePig‐agene
- Mutational signatures in T‐lymphocytes of rats treated with N ‐propyl‐ N‐nitrosourea and procarbazine
Roberta A. Mittelstaedt
National Center for Toxicological Research
4 shared publications
In database
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
- Pig-a mutations in bone marrow erythroblasts of rats treated with 7,12-dimethyl-benz[a]anthracene
- CD59 ‐deficient bone marrow erythroid cells from rats treated with procarbazine and propyl‐nitrosourea have mutations in thePig‐agene
Kidon Sung
National Center for Toxicological Research
4 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequence of a Methicillin-Resistant Staphylococcus aureus ST1413 Strain for Studying Genetic Mechanisms of Antibiotic Resistance
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
- Complete genome sequence of cephalosporin and tetracycline-resistant Citrobacter freundii CF51 isolate from a patient with urinary tract infection
Saeed Khan
National Center for Toxicological Research
4 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequence of a Methicillin-Resistant Staphylococcus aureus ST1413 Strain for Studying Genetic Mechanisms of Antibiotic Resistance
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
- Complete genome sequence of cephalosporin and tetracycline-resistant Citrobacter freundii CF51 isolate from a patient with urinary tract infection
Xiaoqing Guo
National Center for Toxicological Research
4 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Background Mutation Frequencies in TK6 and L5178Y Cells: Implications for Error‐Corrected Sequencing
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
- Mutagenicity of N -nitroso-fluoxetine and N -nitroso-varenicline in human HepaRG cell models
Yiying Wang
National Center for Toxicological Research (US)
3 shared publications
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
Khulud Alotaibi
Saudi Arabian Monetary Authority
3 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of Tetracycline-Resistant Shiga Toxin-Producing Escherichia coli Isolates from Food
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
Ashraf A. Khan
National Center for Toxicological Research
3 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of Tetracycline-Resistant Shiga Toxin-Producing Escherichia coli Isolates from Food
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
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