D
David E. Heinrichs Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Professor
faculty
61 h-index
177 pubs
9,371 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
David E. Heinrichs, a professor at the University of Arkansas at Fayetteville, studies microbial pathogenesis, with a particular focus on *Staphylococcus aureus*. His research investigates how bacteria acquire essential nutrients, such as iron, and how these processes influence virulence and infection. Recent work has explored the role of nucleotide biosynthesis in bacterial pathogenesis and the mechanisms by which bacteria, including coagulase-negative staphylococci, can inhibit *S. aureus* virulence. He has also examined how superantigens contribute to *S. aureus* bloodstream infections and how bacterial surface proteins are displayed.
Heinrichs' research extends to host-pathogen interactions, including how macrophages manage iron acquisition and how this impacts nutritional immunity. His lab investigates the genetic and molecular mechanisms underlying bacterial growth and survival under nutrient-limiting conditions, such as iron restriction. This includes studying the function of specific genes and metabolic pathways, like heme-dependent siderophore utilization in *S. aureus* small-colony variants. He has also explored novel therapeutic strategies, such as induction heating triggering antibiotic release for synergistic bacterial killing on medical implant surfaces.
With an h-index of 61 and over 9,300 citations from 177 publications, Heinrichs is recognized as a highly cited researcher. He collaborates with other researchers at the University of Arkansas, including Vitali Maldonado and Rebekah M. Samsonraj, on multiple shared publications. He maintains an active lab website detailing his research activities.
Metrics
- h-index: 61
- Publications: 177
- Citations: 9,371
Selected Publications
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Examining the Effects of Quercetin on Phenotypic Characteristics of Human Mesenchymal Stem Cells (2025)
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Correction: Assessing the Effects of Dasatinib on Mesenchymal Stem/Stromal Cells (2024)
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Assessing the Effects of Dasatinib on Mesenchymal Stem/Stromal Cells (2024)
Collaboration Network
Top Collaborators
Ronald S. Flannagan
Western University (CA)
20 shared publications
- Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
- Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma production
- Rapid removal of phagosomal ferroportin in macrophages contributes to nutritional immunity
- In vivo growth of Staphylococcus lugdunensis is facilitated by the concerted function of heme and non-heme iron acquisition mechanisms
- Heme-Dependent Siderophore Utilization Promotes Iron-Restricted Growth of the Staphylococcus aureus <i>hemB</i> Small-Colony Variant
Showing 5 of 20 shared publications
Mariya I. Goncheva
Western University (CA)
11 shared publications
- Nucleotide biosynthesis: the base of bacterial pathogenesis
- Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
- Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma production
- Autolysin-mediated peptidoglycan hydrolysis is required for the surface display of <i>Staphylococcus aureus</i> cell wall-anchored proteins
- The Staphylococcus aureus protein IsdA increases SARS CoV-2 replication by modulating JAK-STAT signaling
Showing 5 of 11 shared publications
Izabela Z. Batko
Western University (CA)
6 shared publications
- Heme-Dependent Siderophore Utilization Promotes Iron-Restricted Growth of the Staphylococcus aureus <i>hemB</i> Small-Colony Variant
- Intein-based thermoregulated meganucleases for containment of genetic material
- Heme-dependent siderophore utilization promotes iron-restricted growth of the <i>Staphylococcus aureus hemB</i> small colony variant
- Intein-based thermoregulated meganucleases for biocontainment of genetic material
- Genetic entanglement enables ultra-stable biocontainment in the mammalian gut
Showing 5 of 6 shared publications
Stephen W. Tuffs
University of Victoria (CA)
6 shared publications
- Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma production
- Staphylococcus lugdunensis Uses the Agr Regulatory System to Resist Killing by Host Innate Immune Effectors
- Streptolysin S is required for Streptococcus pyogenes nasopharyngeal and skin infection in HLA-transgenic mice
- Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage function
- Staphylococcal superantigens promote bacterial persistence following postoperative surgical site infection
Showing 5 of 6 shared publications
John K. McCormick
Western University (CA)
6 shared publications
- Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma production
- Staphylococcus lugdunensis Uses the Agr Regulatory System to Resist Killing by Host Innate Immune Effectors
- Streptolysin S is required for Streptococcus pyogenes nasopharyngeal and skin infection in HLA-transgenic mice
- Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage function
- Staphylococcal superantigens promote bacterial persistence following postoperative surgical site infection
Showing 5 of 6 shared publications
Catherine Percher
6 shared publications
- Surrogate Modeling of Criticality Experiments with Mixed Qualitative and Quantitative Factors
- TEX-HEU Baseline Assemblies: Highly Enriched Uranium Plates with Polyethylene Moderator and Polyethylene Reflector (IER-297 CED-4b Report)
- Final Design of a New Pulsed-Neutron Die-Away Experimental Testbed for Thermal Scattering Law Benchmarks (PNDA) (IER-501 CED-2)
- Pulsed-Neutron Die-Away Experiments for Plastics and Neutron Thermal Scattering Laws
- IER-501 CED-3b: Experiment Execution Summary for the Pulsed-Neutron Die-Away Experimental Testbed for Thermal Scattering Law Benchmarks (PNDA)
Showing 5 of 6 shared publications
Denny Chin
Western University (CA)
5 shared publications
- Nucleotide biosynthesis: the base of bacterial pathogenesis
- Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
- Staphylococcus lugdunensis Uses the Agr Regulatory System to Resist Killing by Host Innate Immune Effectors
- Mutations in a Membrane Permease or <i>hpt</i> Lead to 6-Thioguanine Resistance in Staphylococcus aureus
- Draft Genome Sequence of Staphylococcus chromogenes ATCC 43764, a Coagulase-Negative Staphylococcus Strain with Antibacterial Potential
Katherine J. Kasper
Western University (CA)
5 shared publications
- Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma production
- Streptolysin S is required for Streptococcus pyogenes nasopharyngeal and skin infection in HLA-transgenic mice
- Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage function
- Staphylococcal superantigens promote bacterial persistence following postoperative surgical site infection
- Evidence that staphylococcal superantigens promote within-patient bacterial persistence following post-operative surgical site infection
William Zywiec
5 shared publications
- Surrogate Modeling of Criticality Experiments with Mixed Qualitative and Quantitative Factors
- Final Design of a New Pulsed-Neutron Die-Away Experimental Testbed for Thermal Scattering Law Benchmarks (PNDA) (IER-501 CED-2)
- Pulsed-Neutron Die-Away Experiments for Plastics and Neutron Thermal Scattering Laws
- IER-501 CED-3b: Experiment Execution Summary for the Pulsed-Neutron Die-Away Experimental Testbed for Thermal Scattering Law Benchmarks (PNDA)
- IER-501 CED-3b: Experiment Execution Summary for the Pulsed-Neutron Die-Away Experimental Testbed for Thermal Scattering Law Benchmarks (PNDA)
William Zywiec
5 shared publications
- Surrogate Modeling of Criticality Experiments with Mixed Qualitative and Quantitative Factors
- Final Design of a New Pulsed-Neutron Die-Away Experimental Testbed for Thermal Scattering Law Benchmarks (PNDA) (IER-501 CED-2)
- Pulsed-Neutron Die-Away Experiments for Plastics and Neutron Thermal Scattering Laws
- IER-501 CED-3b: Experiment Execution Summary for the Pulsed-Neutron Die-Away Experimental Testbed for Thermal Scattering Law Benchmarks (PNDA)
- IER-501 CED-3b: Experiment Execution Summary for the Pulsed-Neutron Die-Away Experimental Testbed for Thermal Scattering Law Benchmarks (PNDA)
David Watson
Western University (CA)
4 shared publications
- Mechanistic insights and in vivo efficacy of thiosemicarbazones against methicillin-resistant Staphylococcus aureus
- Antimicrobial Studies of Cannabidiol as Biomaterials against superbug MRSA
- GraXRS-Dependent Resistance of Staphylococcus aureus to Human Osteoarthritic Synovial Fluid
- The antimicrobial properties of exogenous copper in human synovial fluid against <i>Staphylococcus aureus</i>
Gary W. Foo
Western University (CA)
4 shared publications
- Intein-based thermoregulated meganucleases for containment of genetic material
- Intein-based thermoregulated meganucleases for biocontainment of genetic material
- Genetic entanglement enables ultra-stable biocontainment in the mammalian gut
- Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut
David R. Edgell
Western University (CA)
4 shared publications
- Intein-based thermoregulated meganucleases for containment of genetic material
- Intein-based thermoregulated meganucleases for biocontainment of genetic material
- Genetic entanglement enables ultra-stable biocontainment in the mammalian gut
- Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut
Jimmy D. Dikeakos
Western University (CA)
3 shared publications
- Rapid removal of phagosomal ferroportin in macrophages contributes to nutritional immunity
- The Staphylococcus aureus protein IsdA increases SARS CoV-2 replication by modulating JAK-STAT signaling
- The <i>Staphylococcus aureus</i> iron-regulated surface determinant A (IsdA) increases SARS CoV-2 replication by modulating JAK-STAT signaling
Verónica Guariglia-Oropeza
Western University (CA)
3 shared publications
- Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
- Heme-Dependent Siderophore Utilization Promotes Iron-Restricted Growth of the Staphylococcus aureus <i>hemB</i> Small-Colony Variant
- Heme-dependent siderophore utilization promotes iron-restricted growth of the <i>Staphylococcus aureus hemB</i> small colony variant
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