Daniel T. Sloper
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Researcher
Also affiliated: University of Minnesota (2005–2014); United States Food and Drug Administration (2020–2024); Veterans Health Administration (2004); University of Minnesota System (2014); University of Minnesota Medical Center (2008–2010); Food and Drug Administration (2015); Center for Systems Biology (2024)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Daniel T. Sloper's research investigates the molecular and cellular mechanisms underlying disease, with a particular focus on prostate inflammation and cancer. His work has explored the identification of altered proteins in rat models of chronic prostatic inflammation induced by sex hormones. Sloper has also examined the effects of specific compounds on prostate health, including the investigation of estradiol/testosterone interactions with gene expression in prostate spheroid models and the efficacy of WL-276, an antagonist against Bcl-2 proteins, in overcoming drug resistance and suppressing prostate tumor growth. Additionally, his research extends to bone health, studying the coadministration of black cohosh extract and risedronate in an ovariectomized rat model. Sloper has 37 publications and an h-index of 12, with recent work published in 2024. He has collaborated with researchers including Noriko Nakamura, Elysia A. Masters, K. Barry Delclos, and Matthew Bryant, all from the National Center for Toxicological Research.
Metrics
- h-index: 12
- Publications: 37
- Citations: 441
Selected Publications
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The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024)
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Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone (2021)
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Identification of Altered Proteins in the Plasma of Rats With Chronic Prostatic Inflammation Induced by Estradiol Benzoate and Sex Hormones (2021)
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Alzheimer’s disease: a step closer to understanding type 3 diabetes in African Americans (2021)
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Comparison of germ cell differentiation of rat testis fragments cultured in knockout serum replacement versus Albumax™ I (2020)
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Gene expression profiling in dorsolateral prostates of prepubertal and adult Sprague-Dawley rats dosed with estradiol benzoate, estradiol, and testosterone (2020)
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Increased estrogen levels altered microRNA expression in prostate and plasma of rats dosed with sex hormones (2020)
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Increased inflammation in BA21 brain tissue from African Americans with Alzheimer’s disease (2019)
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Gene expression profiling of cultured mouse testis fragments treated with ethinylestradiol (2019)
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Metabolomics‐based pathway changes in testis fragments treated with ethinylestradiol in vitro (2019)
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Evaluation of the Performance of Lipidyzer Platform and Its Application in the Lipidomics Analysis in Mouse Heart and Liver (2019)
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Evaluation of an in vitro mouse testis organ culture system for assessing male reproductive toxicity (2018)
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Neurodegenerative Markers are Increased in Postmortem BA21 Tissue from African Americans with Alzheimer’s Disease (2017)
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Evaluation of Culture Time and Media in an <i>In Vitro</i> Testis Organ Culture System (2017)
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Transcriptomics analysis of early embryonic stem cell differentiation under osteoblast culture conditions: Applications for detection of developmental toxicity (2017)
Collaboration Network
Top Collaborators
- Identification of Altered Proteins in the Plasma of Rats With Chronic Prostatic Inflammation Induced by Estradiol Benzoate and Sex Hormones
- Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- Alzheimer’s disease: a step closer to understanding type 3 diabetes in African Americans
- Alzheimer’s disease: a step closer to understanding type 3 diabetes in African Americans
- Alzheimer’s disease: a step closer to understanding type 3 diabetes in African Americans
- Alzheimer’s disease: a step closer to understanding type 3 diabetes in African Americans
- Identification of Altered Proteins in the Plasma of Rats With Chronic Prostatic Inflammation Induced by Estradiol Benzoate and Sex Hormones
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
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