Eric U. Yee

High Impact

Associate Professor

UAMS

Last publication 2026 Last refreshed 2026-05-23

faculty

Pathology, College of Medicine

22 h-index 94 pubs 1,563 cited

Research Areas

Links

ORCID Research Group UAMS TRI Profile

OverviewAI-generated summary

Eric U. Yee's research focuses on understanding disease mechanisms and potential therapeutic interventions, particularly in the context of liver injury and metabolic processes. His work investigates how specific metabolic pathways, such as pyruvate and alanine metabolism in the liver, contribute to antioxidant capacity and resistance to oxidative stress. He has also explored the role of exogenous compounds, like phosphatidic acid, in mitigating liver injury induced by acetaminophen, highlighting inter-organ crosstalk and signaling pathways such as interleukin-6.

Further investigations by Yee examine the cellular and molecular underpinnings of liver diseases, including the contribution of adenosine deaminase 2 produced by monocytes to fibrosis in nonalcoholic fatty liver disease. His research extends to evaluating the effects of various agents on disease models, such as the exacerbation of clostridioides difficile colitis by budesonide in mice and the impact of radiation on methamphetamine pharmacokinetics in rats. Additionally, his group is developing and utilizing advanced tools, including a human quad liver-on-chip system, to bridge the gap between animal models and human responses in toxicology and pharmacology.

Yee leads a research group and has a publication record of 94 articles, with an h-index of 22 and 1,554 citations. He has collaborated with researchers at the University of Arkansas for Medical Sciences, including Felicia D. Allard, Mitchell R. McGill, Stefanie Kennon‐McGill, and Steven R. Post.

Metrics

h-index: 22
Publications: 94
Citations: 1,563

Selected Publications

Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)

DOI OpenAlex
Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)

DOI OpenAlex
Monensin and Its Analogs Offer a Multi-Targeted Approach to Enhancing Metastatic Breast Cancer Immunogenicity and Cell Death (Abstract ID: 163059) (2025)

DOI OpenAlex
474 Repositioning monensin: Enhancing anti-cancer activity and immune modulation in breast cancer cells (2025)

DOI OpenAlex
Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract (2024)

3 citations DOI OpenAlex
Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice (2024)

1 citation DOI OpenAlex
Targeting Tri-Methyl-Histone H3 (Lys27) in Rectal Cancer: A Novel Strategy to Enhance Radiosensitivity and Predict Response to Neoadjuvant Therapy (2023)

DOI OpenAlex
Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult (2023)

25 citations DOI OpenAlex
Budesonide, an anti-inflammatory drug, exacerbate clostridioides difficile colitis in mice (2023)

3 citations DOI OpenAlex
S2431 A Rare Case of Esophageal Kaposi Sarcoma Causing Dysphagia (2022)

DOI OpenAlex
Predicting the Visual Attention of Pathologists Evaluating Whole Slide Images of Cancer (2022)

4 citations DOI OpenAlex
Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice (2022)

2 citations DOI OpenAlex
Radiation Effects on Methamphetamine Pharmacokinetics and Pharmacodynamics in Rats (2022)

3 citations DOI OpenAlex
Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease (2021)

15 citations DOI OpenAlex