E
Esraa Shosha
Assistant Professor
faculty
COM | Pharmacology Channel & Hypertension
14 h-index
48 pubs
666 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Esraa Shosha's research focuses on the mechanisms underlying retinal ischemic injury and potential therapeutic interventions. Her work investigates the role of arginase enzymes, specifically arginase 2 and arginase 1, in mediating damage to the retina following ischemia and reperfusion. Shosha's publications explore how these enzymes contribute to mitochondrial dysfunction and inflammation in the context of retinal diseases. She has also examined the impact of myeloid cells and specific molecular pathways, such as the arginase 1/ornithine decarboxylase pathway and HDAC3, on inflammatory responses and cellular processes like efferocytosis in the retina during ischemic events. Her research extends to investigating metabolic function in conditions like type 1 diabetes and exploring preclinical therapeutic strategies, including the use of pegylated arginase 1, for treating retinal and brain injuries. Shosha collaborates with researchers at the University of Arkansas for Medical Sciences, including Abdelrahman Y. Fouda, Carol Morris, Nancy J. Rusch, and Rami Ahmad Shahror.
Metrics
- h-index: 14
- Publications: 48
- Citations: 666
Selected Publications
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Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy (2025)
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HDAC3 Drives Retinal Endothelial Cell Angiogenesis: Potential Therapeutic Implications for Retinopathy (Abstract ID: 161164) (2025)
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Disrupting the CD47/SIRPα Axis as a Novel and Translational Therapy for Stroke (Abstract ID: 161422) (2025)
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Efferocytosis and retinal clean-up: Role of histone deacetylase 3 in ischemic retinopathy (2025)
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Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology (2024)
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Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024)
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Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions (2024)
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The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury (2023)
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Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair (2022)
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Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice (2022)
Grants & Funding
- Role of endothelial HDAC3 in proliferative retinopathy American Heart Association Principal Investigator
Collaboration Network
Top Collaborators
Abdelrahman Y. Fouda
Cairo University
16 shared publications
In database
- Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
Showing 5 of 16 shared publications
Carol Morris
University of Arkansas for Medical Sciences
7 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- Disrupting the CD47/SIRPα Axis as a Novel and Translational Therapy for Stroke (Abstract ID: 161422)
Showing 5 of 7 shared publications
Ruth B. Caldwell
Discovery Institute (US)
6 shared publications
- Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
Showing 5 of 6 shared publications
Tahira Lemtalsi
Augusta University Health (US)
5 shared publications
- Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- Pegylated Arginase 1 as a Treatment for Acute Central Nervous System (CNS) Injury
Robert W. Caldwell
Discovery Institute (US)
5 shared publications
- Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- Pegylated Arginase 1 as a Treatment for Acute Central Nervous System (CNS) Injury
Zhimin Xu
Augusta University Health (US)
5 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Pegylated Arginase 1 as a Treatment for Acute Central Nervous System (CNS) Injury
Nancy J. Rusch
University of Arkansas for Medical Sciences
5 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- The role of efferocytosis in ischemic stroke and insights from retinopathy
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis
Rami Ahmad Shahror
University of Arkansas for Medical Sciences
4 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
Melissa Wild
University of Arkansas for Medical Sciences
4 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis
Christian D. Mitchell
University of Arkansas for Medical Sciences
4 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- HDAC3 Drives Retinal Endothelial Cell Angiogenesis: Potential Therapeutic Implications for Retinopathy (Abstract ID: 161164)
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis
Paul N. Cheng
3 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Pegylated Arginase 1 as a Treatment for Acute Central Nervous System (CNS) Injury
Syed Zaidi
Discovery Institute (US)
3 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
Ahmed B. Sallam
University of Arkansas for Medical Sciences (US)
3 shared publications
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy
- Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy
Wael Eldahshan
Augusta University Health (US)
2 shared publications
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
- Pegylated Arginase 1 as a Treatment for Acute Central Nervous System (CNS) Injury
S. Priya Narayanan
University of Georgia (US)
2 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury
Similar Researchers
Based on overlapping research topics
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