Esraa Shosha

Assistant Professor

UAMS

Also affiliated: Cairo University (2019–2026); Benha University (2021); Augusta University (2014–2021); Discovery Institute (2015–2021); Charlie Norwood VA Medical Center (2016–2021); Veterans Health Administration (2016); Augusta University Health (2016–2022); Georgia Regents Medical Center (2015–2016)

Faculty Researcher

COM | Pharmacology Channel & Hypertension

15 h-index 48 pubs 686 cited

Research Areas

Biomedical Subjects

Links

ORCID Lab Website UAMS TRI Profile

OverviewAI-generated summary

Esraa Shosha investigates the mechanisms underlying retinal ischemia/reperfusion injury, with a particular focus on the role of arginase enzymes and myeloid cells. Her research has explored how endothelial arginase 2 contributes to mitochondrial dysfunction in the retina during ischemic events. Shosha also studies how arginase 1 can limit abnormal blood vessel growth (neovascularization) in the retina and promote repair. Her work has examined the inflammatory response in myeloid cells and its connection to retinal ischemic injury, including the interplay between the arginase 1/ornithine decarboxylase pathway and inflammatory mediators like HDAC3.

Further research by Shosha has delved into metabolic function in models of diabetes, specifically investigating retinal metabolic function in Akita mice with Type 1 diabetes. She has also explored the potential therapeutic applications of pegylated arginase 1 for treating injuries in both the retina and brain. Shosha collaborates with researchers at the University of Arkansas for Medical Sciences, including Abdelrahman Y. Fouda, Carol Morris, Nancy J. Rusch, and Rami Ahmad Shahror. Her scholarship metrics include an h-index of 15, with 48 total publications and 671 total citations.

Metrics

h-index: 15
Publications: 48
Citations: 686

Selected Publications

CD5L promotes efferocytosis and resolution of retinal ischemic injury (2026)

Cell Death and Disease DOI OpenAlex
A metabolic switch in retinal angiogenesis: Histone deacetylase 3 (2026)

Neural Regeneration Research DOI OpenAlex
Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy (2025)

Journal of Clinical Medicine 2 citations DOI OpenAlex
HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis (2025)

Acta Pharmacologica Sinica 1 citation DOI OpenAlex
HDAC3 Drives Retinal Endothelial Cell Angiogenesis: Potential Therapeutic Implications for Retinopathy (Abstract ID: 161164) (2025)

Journal of Pharmacology and Experimental Therapeutics DOI OpenAlex
Disrupting the CD47/SIRPα Axis as a Novel and Translational Therapy for Stroke (Abstract ID: 161422) (2025)

Journal of Pharmacology and Experimental Therapeutics DOI OpenAlex
Efferocytosis and retinal clean-up: Role of histone deacetylase 3 in ischemic retinopathy (2025)

Neural Regeneration Research DOI OpenAlex
Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology (2024)

Translational Vision Science & Technology 2 citations DOI OpenAlex
Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024)

Journal of Neuroinflammation 16 citations DOI OpenAlex
Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions (2024)

Journal of Neuroinflammation 43 citations DOI OpenAlex
The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury (2023)

Cell Death and Disease 27 citations DOI OpenAlex
Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair (2022)

Cell Death and Disease 49 citations DOI OpenAlex
Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice (2022)

Frontiers in Cardiovascular Medicine 33 citations DOI OpenAlex