Esraa Shosha

Assistant Professor

University of Arkansas for Medical Sciences

faculty

COM | Pharmacology Channel & Hypertension

efshosha@uams.edu

14 h-index 46 pubs 636 cited

Research Areas

Retinal Diseases and Treatments Immune Response and Inflammation Mitochondrial Function and Pathology Pharmacological Effects and Toxicity Studies Diet and metabolism studies Neuroinflammation and Neurodegeneration Mechanisms Immune Cell Function and Interaction

Links

ORCID Lab Website UAMS TRI Profile

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OverviewAI-generated summary

Esraa Shosha, Assistant Professor at the University of Arkansas for Medical Sciences, investigates mechanisms of retinal injury and repair. Her research focuses on the role of arginase enzymes and myeloid cells in proliferative retinopathy and ischemic retinopathies. Shosha's work has explored the therapeutic potential of targeting the arginase 1/ornithine decarboxylase pathway and investigating pegylated arginase 1 for treating retinal and brain injury. She also examines metabolic function in conditions like Type 1 diabetes, specifically within the context of the retina.

Shosha's publications include studies on how arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair, and how arginase 2 mediates retinal ischemia/reperfusion injury. Her recent work also delves into the role of myeloid cells and the impact of deleting myeloid HDAC3 on efferocytosis in retinal ischemic injury. She collaborates with researchers at the University of Arkansas for Medical Sciences, including Abdelrahman Y. Fouda, Carol Morris, Nancy Rusch, and Rami Ahmad Shahror. Shosha's scholarly output is reflected in her h-index of 14 and 636 citations across 46 publications.

Metrics

  • h-index: 14
  • Publications: 46
  • Citations: 636

Selected Publications

  • Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy (2025) DOI
  • HDAC3 Drives Retinal Endothelial Cell Angiogenesis: Potential Therapeutic Implications for Retinopathy (Abstract ID: 161164) (2025) DOI
  • Disrupting the CD47/SIRPĪ± Axis as a Novel and Translational Therapy for Stroke (Abstract ID: 161422) (2025) DOI
  • Efferocytosis and retinal clean-up: Role of histone deacetylase 3 in ischemic retinopathy (2025) DOI
  • Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology (2024) DOI
  • Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024) DOI
  • Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions (2024) DOI
  • The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury (2023) DOI
  • Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair (2022) DOI
  • Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice (2022) DOI

Grants & Funding

  • Role of endothelial HDAC3 in proliferative retinopathy American Heart Association Principal Investigator

Collaborators

Researchers in the database who share publications

Abdelrahman Y. Fouda University of Arkansas for Medical Sciences 16 shared publications Carol Morris University of Arkansas for Medical Sciences 7 shared publications Nancy Rusch University of Arkansas for Medical Sciences 5 shared publications Rami Ahmad Shahror University of Arkansas for Medical Sciences 4 shared publications Christian D. Mitchell University of Arkansas for Medical Sciences 4 shared publications Paul H. Phillips University of Arkansas for Medical Sciences 2 shared publications Aya A Mohammed University of Arkansas for Medical Sciences 2 shared publications Shengyu Mu University of Arkansas for Medical Sciences 1 shared publication

Similar Researchers

Based on overlapping research topics

Grishma KC University of Arkansas for Medical Sciences
Immune Response and Inflammation Mitochondrial Function and Pathology Pharmacological Effects and Toxicity Studies
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Philip Palade University of Arkansas for Medical Sciences
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Abdelrahman Y. Fouda University of Arkansas for Medical Sciences
Retinal Diseases and Treatments Immune Response and Inflammation Mitochondrial Function and Pathology
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Rami Ahmad Shahror University of Arkansas for Medical Sciences
Retinal Diseases and Treatments Immune Response and Inflammation Neuroinflammation and Neurodegeneration Mechanisms
Good match 4 shared topics