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Institution-verified
Presence
Current · Arkansas
Last published
2025
Sources
Institutional record
Refreshed
2026-10-05
F
Frank A. Simmen
Sourced from institutional research profiles (UAMS TRI or ARA).
High Impact
Professor
Also affiliated: Arkansas Children's Hospital (2014); Pennsylvania State University (1990–1996); University of California, San Francisco (2008); Baylor College of Medicine (1984–1985); Washington University in St. Louis (1989); University of Arkansas Medical Center (2009–2012); University of Arkansas System (2004); University of Florida (1989–2004); Arkansas Children's Nutrition Center (2003–2010); Arkansas Children's Research Institute (2014); Institute of Food and Agricultural Sciences (1997–1999); The Ohio State University (1987–2020); University of Missouri (1989); Penn State Milton S. Hershey Medical Center (1996)
54 h-index
206 pubs
7,608 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Frank A. Simmen's research focuses on the molecular mechanisms regulating gene expression, particularly concerning growth factors and steroid hormone action in reproductive tissues. His work has investigated the expression of insulin-like growth factor (IGF) family members and their binding proteins in the endometrium of various species, including swine, cattle, and rats, across different reproductive states such as the estrous cycle and pregnancy. He has also explored the hormonal regulation of these genes in the uterine environment.
Simmen's research extends to the role of transcription factors, such as Krüppel-like Factor 9, in mediating the effects of progesterone on endometrial epithelial cells. Additionally, his work has examined the impact of dietary components, like soy and whey proteins, on gene expression profiles in the colon during tumorigenesis, and the effects of soy isoflavones on mammary epithelial cell signaling. His collaborations include work with Rosalia C. M. Simmen, Iad Alhallak, and Maria Theresa E. Montales at the University of Arkansas for Medical Sciences.
With an h-index of 54, over 200 publications, and more than 7,600 citations, Simmen is recognized as a highly cited researcher. He leads a research group and maintains an active laboratory website, indicating ongoing research activities.
Metrics
- h-index: 54
- Publications: 206
- Citations: 7,608
Positions
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Professor 2002–presentUniversity of Arkansas for Medical Sciences Physiology and Cell Biology Institutional directory
Selected Publications
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Unveiling myometrial SP/Krüppel-like factors as drivers of parturition: insights from transcriptional and endocrine regulatory networks (2025)
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Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis (2023)
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Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice (2023)
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Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet (2022)
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Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice (2021)
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Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10 (2021)
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Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism (2020)
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SUN-126 Distinct Molecular Phenotypes of Non-Diseased Breast Adipose Tissue of Pre-Menopausal Obese and Non-Obese Women May Underlie Differing Breast Cancer Risks (2020)
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Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells (2020)
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Complex epigenetic patterns in cerebellum generated after developmental exposure to trichloroethylene and/or high fat diet in autoimmune-prone mice (2019)
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Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice (2018)
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Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis (2018)
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Opposing Actions of Developmental Trichloroethylene and High-Fat Diet Coexposure on Markers of Lipogenesis and Inflammation in Autoimmune-Prone Mice (2018)
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Tales from the Crypt: Malic Enzyme 1 (ME1) Links Metabolism to Intestinal Cancer (2017)
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Maternal Metabolic State and Cancer Risk: An Evolving Manifestation of Generational Impact (2016)
Collaboration Network
Top Collaborators
Rosalia C. M. Simmen
University of Arkansas for Medical Sciences
28 shared publications
In database
- Krüppel-Like Factor 9 Deficiency in Uterine Endometrial Cells Promotes Ectopic Lesion Establishment Associated With Activated Notch and Hedgehog Signaling in a Mouse Model of Endometriosis
- High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status
- Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism
- Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice
- The Role of Thyroid Hormone Signaling in the Prevention of Digestive System Cancers
Showing 5 of 28 shared publications
Rosalia C.M. Simmen
Arkansas Children's Nutrition Center
26 shared publications
In database
- Selective Interactions of Krüppel-like Factor 9/Basic Transcription Element-binding Protein with Progesterone Receptor Isoforms A and B Determine Transcriptional Activity of Progesterone-responsive Genes in Endometrial Epithelial Cells
- Subfertility, Uterine Hypoplasia, and Partial Progesterone Resistance in Mice Lacking the Krüppel-like Factor 9/Basic Transcription Element-binding Protein-1 (Bteb1) Gene
- Soy Protein Isolate and Protection Against Cancer
- Kruppel-Like Factor 9 Is a Negative Regulator of Ligand-Dependent Estrogen Receptor α Signaling in Ishikawa Endometrial Adenocarcinoma Cells
- Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors
Showing 5 of 26 shared publications
John Mark P. Pabona
Arkansas Children's Nutrition Center (US)
15 shared publications
- High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status
- The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues
- Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice
- Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice
- Nuclear receptor co-regulator Krüppel-like factor 9 and prohibitin 2 expression in estrogen-induced epithelial cell proliferation in the mouse uterus
Showing 5 of 15 shared publications
Thomas M. Badger
Arkansas Children's Nutrition Center
15 shared publications
In database
- Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis.
- Chronic Ethanol Intake Impairs Insulin Signaling in Rats by Disrupting Akt Association with the Cell Membrane
- Soy Protein Isolate and Protection Against Cancer
- Physiologic and Genomic Analyses of Nutrition-Ethanol Interactions During Gestation: Implications for Fetal Ethanol Toxicity
- Dose-Dependent Effects of Alcohol on Insulin Signaling: Partial Explanation for Biphasic Alcohol Impact on Human Health
Showing 5 of 15 shared publications
Rijin Xiao
Arkansas Children's Nutrition Center (US)
14 shared publications
- Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis.
- Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors
- The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression
- Dietary whey protein lowers serum C-peptide concentration and duodenal SREBP-1c mRNA abundance, and reduces occurrence of duodenal tumors and colon aberrant crypt foci in azoxymethane-treated male rats
- Fetal programing of colon cancer in adult rats: correlations with altered neonatal growth trajectory, circulating IGF-I and IGF binding proteins, and testosterone
Showing 5 of 14 shared publications
Ahmed Al‐Dwairi
University of Arkansas for Medical Sciences (US)
11 shared publications
- Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice
- Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice
- Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female Zucker rats bearing DMBA-initiated mammary tumors
Showing 5 of 11 shared publications
Michael C. Velarde
University of Arkansas for Medical Sciences (US)
11 shared publications
- Kruppel-Like Factor 9 Is a Negative Regulator of Ligand-Dependent Estrogen Receptor α Signaling in Ishikawa Endometrial Adenocarcinoma Cells
- The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues
- Delayed Parturition and Altered Myometrial Progesterone Receptor Isoform A Expression in Mice Null for Krüppel-Like Factor 91
- Null Mutation of Kruppel-Like Factor9/Basic Transcription Element Binding Protein-1 Alters Peri-Implantation Uterine Development in Mice1
- Progesterone Receptor Transactivation of the Secretory Leukocyte Protease Inhibitor Gene in Ishikawa Endometrial Epithelial Cells Involves Recruitment of Krüppel-Like Factor 9/Basic Transcription Element Binding Protein-1
Showing 5 of 11 shared publications
Melissa E. Heard
University of Arkansas for Medical Sciences (US)
8 shared publications
- Krüppel-Like Factor 9 Deficiency in Uterine Endometrial Cells Promotes Ectopic Lesion Establishment Associated With Activated Notch and Hedgehog Signaling in a Mouse Model of Endometriosis
- High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status
- Krüppel-Like Factor 9 Loss-of-Expression in Human Endometrial Carcinoma Links Altered Expression of Growth-Regulatory Genes with Aberrant Proliferative Response to Estrogen1
- The Reproductive Phenotype of Mice Null for Transcription Factor Krüppel-Like Factor 13 Suggests Compensatory Function of Family Member Krüppel-Like Factor 9 in the Peri-Implantation Uterus1
- Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis1
Showing 5 of 8 shared publications
Iad Alhallak
University of Arkansas for Medical Sciences
8 shared publications
In database
- Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis
Showing 5 of 8 shared publications
Adam R. Brown
University of Arkansas for Medical Sciences (US)
7 shared publications
- The Role of Thyroid Hormone Signaling in the Prevention of Digestive System Cancers
- Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer
- Abstract 1969: The potential tumor-suppressive role of Kruppel-like factor 9 in colorectal cancer.
Showing 5 of 7 shared publications
Omar Rahal
Arkansas Children's Nutrition Center (US)
6 shared publications
- The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues
- PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation
- Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer
- Maternal blueberry diet suppresses Wnt1‐induced mammary tumor progression in offspring
- Induction of PTEN-p53 Crosstalk in Mammary Epithelial Cells: A Novel Mechanism of Breast Cancer Prevention by the Dietary Factor Genistein.
Showing 5 of 6 shared publications
Maria Theresa E. Montales
University of Arkansas for Medical Sciences
6 shared publications
In database
- Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice
Showing 5 of 6 shared publications
Renea R. Eason
Arkansas Children's Nutrition Center (US)
6 shared publications
- Subfertility, Uterine Hypoplasia, and Partial Progesterone Resistance in Mice Lacking the Krüppel-like Factor 9/Basic Transcription Element-binding Protein-1 (Bteb1) Gene
- Null Mutation of Kruppel-Like Factor9/Basic Transcription Element Binding Protein-1 Alters Peri-Implantation Uterine Development in Mice1
- In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis
- Progesterone Receptor Transactivation of the Secretory Leukocyte Protease Inhibitor Gene in Ishikawa Endometrial Epithelial Cells Involves Recruitment of Krüppel-Like Factor 9/Basic Transcription Element Binding Protein-1
- Uterine phenotype of young adult rats exposed to dietary soy or genistein during development
Showing 5 of 6 shared publications
Martin J. J. Ronis
Arkansas Children's Nutrition Center (US)
6 shared publications
- Chronic Ethanol Intake Impairs Insulin Signaling in Rats by Disrupting Akt Association with the Cell Membrane
- Soy Protein Isolate and Protection Against Cancer
- Physiologic and Genomic Analyses of Nutrition-Ethanol Interactions During Gestation: Implications for Fetal Ethanol Toxicity
- Dose-Dependent Effects of Alcohol on Insulin Signaling: Partial Explanation for Biphasic Alcohol Impact on Human Health
- Post-transcriptional Regulation of Sterol Regulatory Element-binding Protein-1 by Ethanol Induces Class I Alcohol Dehydrogenase in Rat Liver
Showing 5 of 6 shared publications
Ying Su
Arkansas Children's Nutrition Center (US)
5 shared publications
- Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates -catenin signaling in mammary epithelial cells
- Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors
- The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression
- Dietary proteins alter tissue‐specific gene expression and adiposity in male Sprague‐Dawley rats
- Identification of gene networks underlying mammary tumor protection by dietary exposure to soy and genistein