F
Frank A. Simmen Institution-verified
Sourced from institutional research profiles (UAMS TRI or ARA).
High Impact
Professor
faculty
54 h-index
208 pubs
7,573 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Frank A. Simmen's research focuses on the molecular and cellular mechanisms underlying metabolic disorders and cancer. His work investigates the roles of specific genes and proteins in conditions such as obesity, hepatic steatosis, and hepatocellular carcinoma. Dr. Simmen has studied the impact of factors like Malic Enzyme 1 (ME1) and Krüppel-like Factors (KLFs), including KLF9 and KLF13, on adiposity, inflammation, and tumor development, often utilizing rodent models and examining gene expression in relevant tissues.
His investigations also extend to reproductive health, with research exploring the regulation of parturition and the influence of diet on conditions like endometriosis. Collaborations with researchers at the University of Arkansas for Medical Sciences, including Rosalia C. M. Simmen, have contributed to a body of work examining complex biological pathways. Dr. Simmen's publication record includes over 200 papers, and he is recognized as a highly cited researcher with an h-index of 54.
Metrics
- h-index: 54
- Publications: 208
- Citations: 7,573
Selected Publications
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Unveiling myometrial SP/Krüppel-like factors as drivers of parturition: insights from transcriptional and endocrine regulatory networks (2025)
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Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis (2023)
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Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice (2023)
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Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet (2022)
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Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice (2021)
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Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10 (2021)
Collaboration Network
Top Collaborators
Rosalia C. M. Simmen
University of Arkansas for Medical Sciences
6 shared publications
In database
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
- Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice
Showing 5 of 6 shared publications
Iad Alhallak
University of Arkansas for Medical Sciences (US)
5 shared publications
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Krüppel-like Factor-9 and Krüppel-like Factor-13: Highly Related, Multi-Functional, Transcriptional Repressors and Activators of Oncogenesis
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
- Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice
Melissa E. Heard‐Lipsmeyer
University of Arkansas for Medical Sciences (US)
2 shared publications
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice
Stepan B. Melnyk
Arkansas Children's Hospital (US)
2 shared publications
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
- Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice
Maria Theresa E. Montales
University of Arkansas for Medical Sciences
2 shared publications
In database
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
Keith G. Wolter
University of Arkansas for Medical Sciences (US)
1 shared publication
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
Ana Castro Munoz
University of Arkansas for Medical Sciences
1 shared publication
In database
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
Richard Jon Ward
Harding University Main Campus
1 shared publication
In database
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
Stacy A Petty
University of Arkansas for Medical Sciences
1 shared publication
In database
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
Lin‐Xi Li
University of Arkansas for Medical Sciences
1 shared publication
In database
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
Adam R. Brown
University of Arkansas for Medical Sciences (US)
1 shared publication
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
Daniel Habenicht
University of Arkansas for Medical Sciences (US)
1 shared publication
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
Tony Van
University of Arkansas for Medical Sciences (US)
1 shared publication
- Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet
John Mark P. Pabona
University of Arkansas for Medical Sciences (US)
1 shared publication
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
Ahmed Al‐Dwairi
Jordan University of Science and Technology (JO)
1 shared publication
- Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
Similar Researchers
Based on overlapping research topics
Melody Allensworth‐James
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Maternal and Perinatal Health Interventions
Diet and metabolism studies
Rosalia C. M. Simmen
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Cancer-related molecular mechanisms research
Diet and metabolism studies
Tiffany K. Miles
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Maternal and Perinatal Health Interventions
Diet and metabolism studies
James D. Sikes
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Maternal and Perinatal Health Interventions
Diet and metabolism studies
Hannah D. Loy
University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders
Diet and metabolism studies
Disease Mechanisms Research
Kya D Carroll
University of Arkansas for Medical Sciences
Maternal and Perinatal Health Interventions
Diet and metabolism studies
Disease Mechanisms Research