Hui‐Ming Chang
Professor
Also affiliated: Tufts University (1987); Boston Children's Hospital (1987); National Institutes of Health (1986); Naval Medical Research Command (1986–2008); The University of Texas MD Anderson Cancer Center (2000–2004); Harvard University (1986–1992); National Chung Hsing University (2016); Duke University (1992–1994); Chang Gung University (2005); University of Arkansas Medical Center (2025); Massachusetts General Hospital (1989–1992); Kuang Tien General Hospital (2016); IBM Research - Thomas J. Watson Research Center (2003); Duke Medical Center (1994); Stanford Medicine (1999); National Cancer Institute (1986); United States Navy (1986); University of Missouri (2016–2020); Newcastle University (2005); The University of Texas Health Science Center at Houston (1993–2004); Walter Reed Army Institute of Research (1986); Stanford University (1999)
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Hui-Ming Chang's research focuses on understanding the molecular mechanisms underlying cardiovascular complications associated with cancer therapies. As a Principal Investigator, Chang received $489,570 from the NIH/National Heart Lung and Blood Institute for a project investigating the prevention of heart failure induced by Doxorubicin through the early administration of Dexrazoxane. This work aligns with a broader interest in oncocardiology, examining the past, present, and future of this field.
Chang's scholarly contributions include publications on the cardiovascular complications of cancer therapy and the SUMO pathway. Early work investigated defects in glycosylphosphatidylinositol (GPI) anchor biosynthesis and the correction of these defects using transfected yeast genes. Chang has published 66 papers, accumulating 2,835 citations, and holds an h-index of 23. Chang leads a research group at the University of Arkansas for Medical Sciences and collaborates with Edward T.H. Yeh and J.C. Hsu, with whom Chang has shared multiple publications.
Metrics
- h-index: 23
- Publications: 59
- Citations: 2,889
Positions
-
Professor 2020–presentUniversity of Arkansas for Medical Sciences Pharmacology and Internal Medicine Institutional directory
-
Co-Directer, Center for Precision Medicine 2016–2020University of Missouri Columbia Medicine ORCID
-
Vice President for International Programs 2006–2008University of Texas Health Science Center at Houston Office of the President ORCID
-
Special Advisor to the President 2001–2008University of Texas Health Science Center at Houston Office of the President ORCID
-
Faculty 1993–2008The University of Texas Health Science Center at Houston Department of Internal Medicine ORCID
-
Associate Vice President for International Programs 2001–2006University of Texas Health Science Center at Houston Office of the President ORCID
-
Associate Professor, Director of Education 1996–2003University of Texas MD Anderson Cancer Center Anesthesiology, Pain Medicine, Palliative Care ORCID
-
Faculty 1989–1993Massachusetts General Hospital Anesthesia ORCID
Selected Publications
-
PP4 modulates macrophage-neutrophil crosstalk to restrict CCL5 -driven NETosis in sepsis (2026)
-
Prevention of Heart Failure Induced by Doxorubicin with Early Administration of Dexrazoxane (PHOENIX Study): dose response and time course of dexrazoxane-induced degradation of topoisomerase 2b (2025)
-
Microglia‐Mediated Synaptic Dysfunction Contributes to Chemotherapy‐Related Cognitive Impairment (2025)
-
Abstract 12348: Targeted Degradation of Topoisomerase 2b by Dexrazoxane for Prevention of Doxorubicin-Induced Cardiotoxicity: Dose and Time Course Study in Human (2023)
-
Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension (2023)
-
Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells (2023)
-
Signaling pathways involved in NMDA ‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala (2022)
-
Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4 (2022)
-
Abstract 9710: Prevention of Doxorubicin-Induced Cardiotoxicity Through Targeted Degradation of Topoisomerase 2b (2021)
-
Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4 (2021)
-
Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension (2021)
Federal Grants 1 $489,570 total
Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- PATHOBIOLOGY OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA NIH
- STUDIES OF THE SENTRIN FAMILY OF UBIQUITIN-LIKE PROTEINS NIH
- PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA NIH
Collaboration Network
Top Collaborators
- Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension
- Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension
- Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4
- Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells
- Signaling pathways involved in NMDA ‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala
Showing 5 of 11 shared publications
- Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension
- Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells
- Signaling pathways involved in NMDA ‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala
- Microglia‐Mediated Synaptic Dysfunction Contributes to Chemotherapy‐Related Cognitive Impairment
- Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4
- Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension
- Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension
- Signaling pathways involved in NMDA ‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala
- Microglia‐Mediated Synaptic Dysfunction Contributes to Chemotherapy‐Related Cognitive Impairment
- Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension
- Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension
- Signaling pathways involved in NMDA ‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala
- Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension
- Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension
- Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension
- Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension
- Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension
- Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension
- Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension
- Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension
- Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells
- Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4
- Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells
- Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4
- Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells
- Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4
- Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells
- Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4
- Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells
- Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4
- Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells
- Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4
- Signaling pathways involved in NMDA ‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala
- Microglia‐Mediated Synaptic Dysfunction Contributes to Chemotherapy‐Related Cognitive Impairment
Similar Researchers
Based on overlapping research topics