Hui‐Ming Chang

Federal Grant PI High Impact

Professor

UAMS

Faculty Researcher

23 h-index 66 pubs 2,835 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group UAMS TRI Profile

OverviewAI-generated summary

Hui-Ming Chang's research program focuses on understanding the molecular and cellular mechanisms underlying disease, with a particular emphasis on cardiovascular conditions and cancer. Chang has investigated the role of specific ion channels, such as Kv7 channels, in the central amygdala and their contribution to elevated sympathetic outflow in hypertension. This work has explored the involvement of corticotropin-releasing hormone neurons in stress-induced hypertension and the signaling pathways, including NMDA receptor activity, that modulate neuronal function.

In parallel, Chang's laboratory studies acute myeloid leukemia stem cells, identifying dipeptidylpeptidase 4 as a promoter of their survival and stemness. Further research extends to chemotherapy-induced cognitive impairment, examining the role of microglia-mediated synaptic dysfunction. A significant portion of Chang's funded work, supported by a $489,570 NIH/NHLBI grant, investigates the prevention of doxorubicin-induced heart failure and the dose-response and time course of dexrazoxane's effects on topoisomerase 2b degradation. Chang holds a high-impact researcher designation, evidenced by an h-index of 23 and over 2,800 citations across 66 publications, and collaborates with researchers Edward T.H. Yeh and J.C. Hsu at the University of Arkansas for Medical Sciences.

Metrics

h-index: 23
Publications: 66
Citations: 2,835

Selected Publications

PP4 modulates macrophage-neutrophil crosstalk to restrict CCL5 -driven NETosis in sepsis (2026)

Redox Biology DOI OpenAlex
Prevention of Heart Failure Induced by Doxorubicin with Early Administration of Dexrazoxane (PHOENIX Study): dose response and time course of dexrazoxane-induced degradation of topoisomerase 2b (2025)

Cardio-Oncology 4 citations DOI OpenAlex
Microglia‐Mediated Synaptic Dysfunction Contributes to Chemotherapy‐Related Cognitive Impairment (2025)

Journal of Neurochemistry 3 citations DOI OpenAlex
Abstract 12348: Targeted Degradation of Topoisomerase 2b by Dexrazoxane for Prevention of Doxorubicin-Induced Cardiotoxicity: Dose and Time Course Study in Human (2023)

Circulation 1 citation DOI OpenAlex
Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension (2023)

Cardiovascular Research 21 citations DOI OpenAlex
Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells (2023)

Cell Reports 12 citations DOI OpenAlex
Signaling pathways involved in <scp>NMDA</scp>‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala (2022)

Journal of Neurochemistry 6 citations DOI OpenAlex
Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4 (2022)

SSRN Electronic Journal DOI OpenAlex
Abstract 9710: Prevention of Doxorubicin-Induced Cardiotoxicity Through Targeted Degradation of Topoisomerase 2b (2021)

Circulation DOI OpenAlex
Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4 (2021)

Proceedings of the National Academy of Sciences 13 citations DOI OpenAlex
Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension (2021)

Cardiovascular Research 25 citations DOI OpenAlex