Hyun-Ki Kang

Researcher

National Center for Toxicological Research

unknown

4 h-index 6 pubs 41 cited

Research Areas

Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment Diet and metabolism studies Smoking Behavior and Cessation

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OverviewAI-generated summary

Hyun-Ki Kang's research focuses on the toxicological and pharmacokinetic evaluation of chemical compounds, particularly in the context of exposure routes relevant to human health. His work has involved studying the effects of NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone), a known carcinogen found in tobacco products, in Sprague-Dawley rats. Kang has investigated NNK's toxicokinetic profile, including its genotoxicity and dose-response relationships through various administration methods such as nose-only inhalation, intraperitoneal injection, and oral gavage. He has also examined the pharmacokinetics of nicotine and its metabolites, cotinine and 3′-hydroxycotinine, following different exposure scenarios, including nose-only inhalation, oral gavage, and intravenous infusion. These studies contribute to understanding the absorption, distribution, metabolism, and excretion of these compounds, informing risk assessment related to tobacco use.

Metrics

  • h-index: 4
  • Publications: 6
  • Citations: 41

Selected Publications

  • Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024) DOI
  • 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021) DOI
  • 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021) DOI
  • Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021) DOI

Collaborators

Researchers in the database who share publications

Matthew Bryant National Center for Toxicological Research 4 shared publications Sherry M. Lewis National Center for Toxicological Research 4 shared publications Shu-Chieh Hu National Center for Toxicological Research 4 shared publications Paul C. Howard National Center for Toxicological Research 4 shared publications Seonggi Min National Center for Toxicological Research 3 shared publications Dong-Jin Yang National Center for Toxicological Research 3 shared publications Raúl Trbojevich National Center for Toxicological Research 3 shared publications Mason G. Pearce National Center for Toxicological Research 3 shared publications

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