M
Mason G. Pearce Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Researcher
faculty
15 h-index
35 pubs
704 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Mason G. Pearce's research focuses on toxicokinetics and genotoxicity, utilizing various exposure routes and animal models, primarily Sprague-Dawley rats. His work investigates the dose-response relationships of chemical agents, including NNK, a known mutagen and carcinogen. Pearce has published studies examining the effects of agents like NNK via nose-only inhalation, intraperitoneal injection, and oral gavage, often assessing parameters such as toxicity and Haber's Rule. His research also explores the impact of life stage and tissue type on genotoxicity assessments, using agents like ethyl methane sulfonate. Further investigations involve the use of specific gene mutations, such as PIG-A, as biomarkers for mutagenicity in both animal models (F344 rats) and human populations, including cancer patients undergoing specific treatments. Pearce employs advanced sequencing techniques to evaluate mutagenicity in humans. He has a publication record of 35 papers, with 702 citations, and an h-index of 15. Key collaborators include Robert H. Heflich, Page B. McKinzie, Vasily N. Dobrovolsky, and Mackean P. Maisha, all from the National Center for Toxicological Research.
Metrics
- h-index: 15
- Publications: 35
- Citations: 704
Selected Publications
-
Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans (2026)
-
Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin (2024)
-
90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021)
-
Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity (2021)
-
14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021)
-
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)
-
<i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats (2021)
Collaboration Network
Top Collaborators
Robert H. Heflich
United States Food and Drug Administration
5 shared publications
In database
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
Page B. McKinzie
National Center for Toxicological Research
3 shared publications
In database
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
- Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans
Vasily N. Dobrovolsky
National Center for Toxicological Research
3 shared publications
In database
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
- Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans
Shu-Chieh Hu
United States Food and Drug Administration
3 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Matthew Bryant
National Center for Toxicological Research
3 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Estatira Sepehr
United States Food and Drug Administration (US)
3 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Hyun-Ki Kang
United States Food and Drug Administration
3 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Raúl Trbojevich
National Center for Toxicological Research
3 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Michelle E. Bishop
United States Food and Drug Administration
3 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Kelly J. Davis
National Center for Toxicological Research (US)
3 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Sherry M. Lewis
United States Food and Drug Administration
3 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Susan Chemerynski
United States Food and Drug Administration (US)
3 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Steven B. Yee
United States Food and Drug Administration (US)
3 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Melis Coraggio
United States Food and Drug Administration (US)
3 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Hans Rosenfeldt
United States Food and Drug Administration (US)
3 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Similar Researchers
Based on overlapping research topics
Shu-Chieh Hu
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies
Hyun-Ki Kang
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies
Joseph G. Shaddock
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies
Javed A. Bhalli
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies
Abby Fulbright
University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies
Metabolism and Genetic Disorders
Heflich Rh
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Disease Mechanisms Research