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Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
M
Mason G. Pearce
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Also affiliated: United States Food and Drug Administration (2008–2026)
16 h-index
35 pubs
715 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Mason G. Pearce's research investigates the genotoxicity and cytotoxicity of various chemical compounds and nanoparticles in animal models. His work has focused on assessing the mutagenic potential of substances such as acrylamide, glycidyl methacrylate, silver nanoparticles, and titanium dioxide nanoparticles. Pearce has utilized established methodologies, including the Pig-a mutation assay and micronucleus tests, often in conjunction with flow cytometry, to evaluate dose-response relationships and compare different genotoxicity endpoints.
Metrics
- h-index: 16
- Publications: 35
- Citations: 715
Selected Publications
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Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans (2026)
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Erythrocyte PIG‐A mutant frequencies in cancer patients receiving cisplatin (2024)
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90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021)
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Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity (2021)
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14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021)
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Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)
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Pig‐a gene mutations in bone marrow granulocytes of procarbazine‐treated F344 rats (2021)
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CD59 ‐deficient bone marrow erythroid cells from rats treated with procarbazine and propyl‐nitrosourea have mutations in thePig‐agene (2020)
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Pig-a mutations in bone marrow erythroblasts of rats treated with 7,12-dimethyl-benz[a]anthracene (2019)
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Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays (2018)
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Lifespan Kras mutation levels in lung and liver of B6C3F1 mice (2018)
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Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells (2018)
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Analysis of mutation in the rat Pig‐a assay: II. Studies with bone marrow granulocytes (2018)
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Genome-wide mutation detection by interclonal genetic variation (2018)
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Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine (2017)
Collaboration Network
Top Collaborators
Vasily N. Dobrovolsky
National Center for Toxicological Research
22 shared publications
In database
- In vivo genotoxicity assessment of acrylamide and glycidyl methacrylate
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens
Showing 5 of 22 shared publications
Robert H. Heflich
National Center for Toxicological Research
16 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Quantitative dose–response analysis of ethyl methanesulfonate genotoxicity in adult gpt‐delta transgenic mice
- Manifestation and persistence of Pig‐a mutant red blood cells in C57BL/6 mice following single and split doses of N‐ethyl‐N‐nitrosourea
Showing 5 of 16 shared publications
Javier R. Revollo
National Center for Toxicological Research
13 shared publications
In database
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- CD48‐deficient T‐lymphocytes from DMBA‐treated rats have de novo mutations in the endogenous Pig‐a gene
- Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
Showing 5 of 13 shared publications
Azra Dad
National Center for Toxicological Research
10 shared publications
In database
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
- Genome-wide mutation detection by interclonal genetic variation
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
- Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells
Showing 5 of 10 shared publications
Wei Ding
National Center for Toxicological Research (US)
9 shared publications
- Cytotoxicity and genotoxicity assessment of silver nanoparticles in mouse
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- In vivo genotoxicity assessment of acrylamide and glycidyl methacrylate
- Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow‐cytometric peripheral blood micronucleus test, and pathway‐focused gene expression profiling
- Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, Aristolochic acids
Showing 5 of 9 shared publications
Roberta A. Mittelstaedt
National Center for Toxicological Research
8 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Quantitative dose–response analysis of ethyl methanesulfonate genotoxicity in adult gpt‐delta transgenic mice
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
Showing 5 of 8 shared publications
Michelle E. Bishop
National Center for Toxicological Research
8 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow‐cytometric peripheral blood micronucleus test, and pathway‐focused gene expression profiling
- In vivo genotoxicity of estragole in male F 344 rats
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats
Showing 5 of 8 shared publications
Javed A. Bhalli
Covance (United States)
8 shared publications
In database
- Cytotoxicity and genotoxicity assessment of silver nanoparticles in mouse
- Genotoxicity of TiO2 anatase nanoparticles in B6C3F1 male mice evaluated using Pig-a and flow cytometric micronucleus assays
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens
Showing 5 of 8 shared publications
Page B. McKinzie
National Center for Toxicological Research
8 shared publications
In database
- Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine
- Spectrum of benzo[ a ]pyrene-induced mutations in the Pig-a gene of L5178Y Tk +/− cells identified with next generation sequencing
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
- Lifespan Kras mutation levels in lung and liver of B6C3F1 mice
Showing 5 of 8 shared publications
Joseph G. Shaddock
National Center for Toxicological Research
5 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens
- Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, Aristolochic acids
Kelly J. Davis
National Center for Toxicological Research
5 shared publications
In database
- In vivo genotoxicity of estragole in male F 344 rats
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Hans Rosenfeldt
United States Food and Drug Administration (US)
5 shared publications
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
- Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Xuefei Cao
National Center for Toxicological Research
4 shared publications
In database
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Quantitative dose–response analysis of ethyl methanesulfonate genotoxicity in adult gpt‐delta transgenic mice
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
Mugimane G. Manjanatha
National Center for Toxicological Research
4 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow‐cytometric peripheral blood micronucleus test, and pathway‐focused gene expression profiling
- In vivo genotoxicity of estragole in male F 344 rats
- Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats
Dayton M. Petibone
National Center for Toxicological Research
4 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats
- Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells
- Analysis of mutation in the rat Pig‐a assay: II. Studies with bone marrow granulocytes
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