Mason G. Pearce Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

National Center for Toxicological Research

faculty

15 h-index 35 pubs 696 cited

Research Areas

Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications Cancer-related molecular mechanisms research Genomics and Phylogenetic Studies

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Mason G. Pearce's research focuses on toxicological studies, particularly investigating the genotoxicity and toxicokinetics of chemical compounds. His recent publications examine the effects of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a known carcinogen, in Sprague-Dawley rats through various exposure routes, including nose-only inhalation, intraperitoneal injection, and oral gavage. Pearce has also studied the dose-response assessment of ethyl methane sulfonate-induced genotoxicity across different life stages and target tissues. His work extends to evaluating mutagenicity in human populations, as evidenced by research on erythrocyte PIG-A mutant frequencies in cancer patients undergoing cisplatin treatment and the use of error-corrected sequencing for assessing molnupiravir mutagenicity in humans. He has collaborated with researchers at the National Center for Toxicological Research, including Robert H. Heflich, Page B. McKinzie, Vasily N. Dobrovolsky, and Mackean P. Maisha, co-authoring multiple publications with each.

Metrics

  • h-index: 15
  • Publications: 35
  • Citations: 696

Selected Publications

  • Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans (2026) DOI
  • Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin (2024) DOI
  • 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021) DOI
  • Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity (2021) DOI
  • 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021) DOI
  • Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021) DOI
  • <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats (2021) DOI

Collaborators

Researchers in the database who share publications

Robert H. Heflich National Center for Toxicological Research 5 shared publications Page B. McKinzie National Center for Toxicological Research 3 shared publications Vasily N. Dobrovolsky National Center for Toxicological Research 3 shared publications Mackean P. Maisha National Center for Toxicological Research 3 shared publications Matthew Bryant National Center for Toxicological Research 3 shared publications Sherry M. Lewis National Center for Toxicological Research 3 shared publications Shu-Chieh Hu National Center for Toxicological Research 3 shared publications Raúl Trbojevich National Center for Toxicological Research 3 shared publications

Similar Researchers

Based on overlapping research topics

Ji‐Eun Seo National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Strong match 5 shared topics
Azra Dad National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Strong match 5 shared topics
Page B. McKinzie National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Strong match 5 shared topics
Gunnar Boysen University of Arkansas for Medical Sciences
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Strong match 5 shared topics
Michelle E. Bishop National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Cancer-related molecular mechanisms research
Strong match 4 shared topics
Karen L. McKim National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Cancer-related molecular mechanisms research
Strong match 4 shared topics