Biography and Research Information
OverviewAI-generated summary
Jaideep B. Bharate's research focuses on the discovery and optimization of novel therapeutic agents, particularly in the area of oncology. His work involves structure-based drug design and synthesis, with recent publications detailing the development of inhibitors for FLT3 and RET kinases, which are implicated in acute myeloid leukemia and certain cancers, respectively. These efforts often utilize pyrimidine and imidazo[1,2-a]pyridine derivatives as core structures. Bharate also investigates synthetic methodologies, including tandem ring opening/intramolecular cycloaddition reactions for constructing novel heterocyclic compounds. His research network includes collaborators from the University of Arkansas for Medical Sciences, with whom he has co-authored multiple publications. Bharate's scholarship is reflected in his h-index of 16, with 35 total publications and 756 citations.
Metrics
- h-index: 16
- Publications: 35
- Citations: 762
Selected Publications
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Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose (2022)
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Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor (2021)
Collaboration Network
Top Collaborators
Jörgen Ådén
3 shared publications
- Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones
- K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones
- CCDC 2087355: Experimental Crystal Structure Determination
Anna L. Gharibyan
3 shared publications
- Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones
- K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones
- CCDC 2087355: Experimental Crystal Structure Determination
Dan E. Adolfsson
3 shared publications
- Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones
- K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones
- CCDC 2087355: Experimental Crystal Structure Determination
Sanduni Wasana Jayaweera
3 shared publications
- Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones
- K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones
- CCDC 2087355: Experimental Crystal Structure Determination
Pardeep Singh
3 shared publications
- Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones
- K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones
- CCDC 2087355: Experimental Crystal Structure Determination
Mohit Tyagi
3 shared publications
- Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones
- K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones
- CCDC 2087355: Experimental Crystal Structure Determination
Anders Olofsson
3 shared publications
- Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones
- K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones
- CCDC 2087355: Experimental Crystal Structure Determination
Lingtian Zhang
University of Arkansas for Medical Sciences (US)
2 shared publications
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
Naga Rajiv Lakkaniga
Scripps Research Institute (US)
2 shared publications
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
Xiuqi Wang
University of Arkansas for Medical Sciences
2 shared publications
In database
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
Anupreet Kharbanda
University of Arkansas for Medical Sciences
2 shared publications
In database
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
Yuet‐Kin Leung
University of Arkansas for Medical Sciences
2 shared publications
In database
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
Brendan Frett
University of Arkansas for Medical Sciences
2 shared publications
In database
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
Hongyu Li
University of Arkansas for Medical Sciences (US)
2 shared publications
- Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor
- Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose
Anita Kiss
2 shared publications
- Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones
- CCDC 2087355: Experimental Crystal Structure Determination
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