Jaideep B. Bharate

Senior Research Investigator

University of Arkansas for Medical Sciences

faculty

16 h-index 35 pubs 754 cited

Research Areas

Cancer Treatment and Pharmacology Acute Myeloid Leukemia Research Computational Drug Discovery Methods Synthesis and biological activity Protein Structure and Dynamics Molecular Biology Techniques and Applications

Links

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OverviewAI-generated summary

Jaideep B. Bharate's research focuses on the discovery and development of novel therapeutic agents, particularly in the area of oncology. His work has involved the identification of small molecule inhibitors targeting specific kinases implicated in cancer progression, such as FLT3 and RET. Recent publications detail the structure-based optimization of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 inhibitors for acute myeloid leukemia and the development of N-trisubstituted pyrimidine derivatives as inhibitors of Type I RET and RET gatekeeper mutants. Bharate also investigates synthetic methodologies, including tandem ring opening/intramolecular cycloaddition reactions for the synthesis of complex heterocyclic structures like cyclobutane fused thiazolino-2-pyridones. His research network includes collaborators such as Yuet‐Kin Leung, Brendan Frett, Anupreet Kharbanda, and Xiuqi Wang, all affiliated with the University of Arkansas for Medical Sciences. With an h-index of 16 and 754 citations across 35 publications, his work contributes to the field of medicinal chemistry and drug discovery.

Metrics

  • h-index: 16
  • Publications: 35
  • Citations: 754

Selected Publications

  • Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose (2022) DOI
  • Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor (2021) DOI

Collaborators

Researchers in the database who share publications

Yuet‐Kin Leung University of Arkansas for Medical Sciences 2 shared publications Brendan Frett University of Arkansas for Medical Sciences 2 shared publications Anupreet Kharbanda University of Arkansas for Medical Sciences 2 shared publications Xiuqi Wang University of Arkansas for Medical Sciences 2 shared publications Phuc Tran University of Arkansas for Medical Sciences 1 shared publication

Similar Researchers

Based on overlapping research topics

Anupreet Kharbanda University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology Computational Drug Discovery Methods Protein Structure and Dynamics
Good match 4 shared topics
A. E. Elkhouly University of Arkansas at Fayetteville
Computational Drug Discovery Methods Protein Structure and Dynamics Molecular Biology Techniques and Applications
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Ahmed Shubbar University of Arkansas at Fayetteville
Cancer Treatment and Pharmacology Computational Drug Discovery Methods Protein Structure and Dynamics
Good match 4 shared topics
Darin E. Jones University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology Computational Drug Discovery Methods Protein Structure and Dynamics
Good match 4 shared topics
Alan Herrera-Rueda University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology Protein Structure and Dynamics Molecular Biology Techniques and Applications
Good match 3 shared topics
Adithya Polasa Vivek Govind Kumar University of Arkansas at Fayetteville
Computational Drug Discovery Methods Protein Structure and Dynamics Molecular Biology Techniques and Applications
Good match 3 shared topics