Jason E. Farrar
High Impact
Professor
faculty
Peds Pediatrics, College of Medicine
25 h-index
149 pubs
3,055 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Jason E. Farrar's research focuses on the molecular and clinical characterization of pediatric hematologic malignancies, particularly acute myeloid leukemia (AML), and rare genetic disorders like Diamond-Blackfan anemia. His work investigates the genetic underpinnings and prognostic factors in these conditions, aiming to improve diagnosis, treatment, and patient outcomes. He has co-authored publications on comprehensive molecular and clinical characterization of NUP98 fusions in pediatric AML, integrated stem cell signatures for risk determination, and the role of long noncoding RNA expression in predicting outcomes. Farrar also contributed to an international consensus statement on the diagnosis, treatment, and surveillance of Diamond-Blackfan anemia syndrome.
His research extends to understanding the mechanisms of leukemogenesis, as seen in his work on ZMYND11-MBTD1's role in hijacking cellular complexes. He has also explored treatment efficacy, including the use of CPX-351 in pediatric secondary myeloid malignancies. Farrar is a Co-PI on the NIH-funded CTSA K12 Program at the University of Arkansas for Medical Sciences, totaling $756,000, which supports translational research. His collaborations include work with fellow researchers at the University of Arkansas for Medical Sciences, such as Samrat Roy Choudhury and Lauren Appell. Farrar maintains an active lab website to disseminate his group's work.
Metrics
- h-index: 25
- Publications: 149
- Citations: 3,055
Selected Publications
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Central nervous system-symptomatic hyperammonemia following recombinant crisantaspase Pseudomonas fluorescens (2026)
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A supervised STreNgth & Outpatient Exercise Regimen in pediatric patients with Acute Lymphoblastic Leukemia (STRONGER ALL) (2026)
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Transcriptional rewiring by enhancer methylation in CBFA2T3-GLIS2–driven pediatric acute megakaryoblastic leukemia (2025)
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Eltrombopag in combination with immunosuppressive therapy in pediatric severe aplastic anemia: phase 2 ESCALATE trial (2025)
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Lymphoid malignancies in patients with Shwachman-Diamond syndrome (2025)
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Evaluation of recurrent and recalcitrant warts in a deaf adolescent male reveals GATA2 deficiency (2024)
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Diagnosis, treatment, and surveillance of Diamond-Blackfan anaemia syndrome: international consensus statement (2024)
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Abstract P16: CBFA2T3-GLIS2 fusion leads to a distinct DNA methylation enhancer landscape in pediatric acute myeloid leukemia (2024)
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Enhancer‐activated <scp>RET</scp> confers protection against oxidative stress to <scp>KMT2A</scp>‐rearranged acute myeloid leukemia (2024)
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Lymphoid Malignancies in Shwachman-Diamond Syndrome: Incidence, Clinical Features, and Outcomes from the North American SDS Registry (2023)
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The Role of FAS Receptor Methylation in Osteosarcoma Metastasis (2023)
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Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia (2023)
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Transcriptome Analysis and Machine Learning Prioritize Therapeutic Strategies for High-Risk Pediatric AML Patients of the KMT2A-Fusion Subgroup (2022)
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Expanding the High-Risk Definition for Children with Newly Diagnosed Acute Myeloid Leukemia (2022)
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Eltrombopag in Pediatric Patients with Previously Untreated or Refractory/Relapsed Severe Aplastic Anemia: The Phase II Escalate Trial (2022)
Federal Grants 1 $756,000 total
NIH/National Center for Advancing Translational Sciences
Co-PI
Jul 2024 - Jun 2029
CTSA K12 Program at the University of Arkansas for Medical Sciences
Grants & Funding
- No FP attached UAMS ACHRI Flow Through Principal Investigator
- GR034151 Farrar ACHRI Mechanisms of Erythroid Remission in Diamond Blackfan Anemia (DBA) UAMS ACHRI Flow Through Principal Investigator
- No FP attached UAMS ACHRI Flow Through Principal Investigator
- Integrative Genomics in Pediatric AML Arkansas Children's Research Institute Principal Investigator
- No FP attached UAMS ACHRI Flow Through Principal Investigator
- Role of HELB in the Replication Stress Response Dr. Tacketts COBRA through ACRI NIH/Nat. Inst. of General Medical Sciences - Pass Through: Arkansas Children's Research Institute Principal Investigator
- St. Baldrick's Subaward St. Baldrick's Foundation - Pass Through: Fred Hutchinson Cancer Research Center Principal Investigator
- No FP attached UAMS ACHRI Flow Through Principal Investigator
Collaboration Network
Top Collaborators
Rhonda E. Ries
Fred Hutch Cancer Center (US)
32 shared publications
- Comprehensive molecular and clinical characterization of <i>NUP98</i> fusions in pediatric acute myeloid leukemia
- Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia
- Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia
- A B-cell developmental gene regulatory network is activated in infant AML
- CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
Showing 5 of 32 shared publications
Soheil Meshinchi
Fred Hutch Cancer Center (US)
29 shared publications
- Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia
- Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia
- A B-cell developmental gene regulatory network is activated in infant AML
- CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
- Structural variants involving <i>MLLT10</i> fusion are associated with adverse outcomes in pediatric acute myeloid leukemia
Showing 5 of 29 shared publications
Todd A. Alonzo
University of Southern California (US)
28 shared publications
- Comprehensive molecular and clinical characterization of <i>NUP98</i> fusions in pediatric acute myeloid leukemia
- Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia
- Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia
- CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
- Structural variants involving <i>MLLT10</i> fusion are associated with adverse outcomes in pediatric acute myeloid leukemia
Showing 5 of 28 shared publications
Alan S. Gamis
Children's Mercy Hospital (US)
27 shared publications
- Comprehensive molecular and clinical characterization of <i>NUP98</i> fusions in pediatric acute myeloid leukemia
- Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia
- Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia
- CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
- Structural variants involving <i>MLLT10</i> fusion are associated with adverse outcomes in pediatric acute myeloid leukemia
Showing 5 of 27 shared publications
Jaime M. Guidry Auvil
National Cancer Institute (US)
16 shared publications
- The Role of FAS Receptor Methylation in Osteosarcoma Metastasis
- Data from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Showing 5 of 16 shared publications
Daniela S. Gerhard
National Cancer Institute (US)
16 shared publications
- The Role of FAS Receptor Methylation in Osteosarcoma Metastasis
- Data from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Showing 5 of 16 shared publications
Jenny L. Smith
15 shared publications
- Comprehensive molecular and clinical characterization of <i>NUP98</i> fusions in pediatric acute myeloid leukemia
- Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia
- Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia
- A B-cell developmental gene regulatory network is activated in infant AML
- CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
Showing 5 of 15 shared publications
Heather L. Schuback
15 shared publications
- Data from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 3 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Showing 5 of 15 shared publications
Daniel Wai
15 shared publications
- Data from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 3 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Showing 5 of 15 shared publications
Oliver Hampton
15 shared publications
- Data from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 3 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Showing 5 of 15 shared publications
Lisa R. Treviño
15 shared publications
- Data from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 3 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Showing 5 of 15 shared publications
Tanja M. Davidsen
15 shared publications
- Data from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 3 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Showing 5 of 15 shared publications
Patee Gesuwan
15 shared publications
- Data from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 3 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Showing 5 of 15 shared publications
Leandro C. Hermida
15 shared publications
- Data from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 3 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Showing 5 of 15 shared publications
Donna M. Muzny
15 shared publications
- Data from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Figure 4 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 1 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 2 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
- Supplemental Table 3 from Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Showing 5 of 15 shared publications
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