Match tier
Likely match
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
J
Joseph G. Shaddock
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
Role not yet determined Is this you? Add your title
Also affiliated: Leiden University (1994); United States Food and Drug Administration (1981–2025)
25 h-index
66 pubs
1,624 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Joseph G. Shaddock's research focuses on investigating mutagenicity and genotoxicity. He studies mutation detection in the Hprt and Pig-a genes of rat lymphocytes, and has published work differentiating micronucleus dose-responses induced by whole cigarette smoke solutions. Shaddock's scholarship metrics include an h-index of 25, with 66 total publications and 1,610 total citations. He is designated as a highly cited researcher. His key collaborators at the National Center for Toxicological Research include Roberta A. Mittelstaedt and Robert H. Heflich, with whom he has co-authored multiple publications.
Metrics
- h-index: 25
- Publications: 66
- Citations: 1,624
Selected Publications
-
Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes (2025)
-
Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking (2021)
-
Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes (2020)
-
Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes (2019)
-
Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes (2014)
-
Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes (2013)
-
Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens (2013)
-
Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells (2013)
-
Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, Aristolochic acids (2013)
-
In vivo genotoxicity of furan in F344 rats at cancer bioassay doses (2012)
-
Analysis of mutations in the Pig‐a gene of spleen T‐cells from N‐ethyl‐N‐nitrosourea‐treated fisher 344 rats (2011)
-
Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines (2011)
-
Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints (2011)
-
Report on stage IIIPig‐amutation assays using benzo[a]pyrene (2011)
-
Genotoxicity of furan in Big Blue rats (2011)
Collaboration Network
Top Collaborators
Robert H. Heflich
National Center for Toxicological Research
28 shared publications
In database
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Genotoxicity of furan in Big Blue rats
- Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines
- DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide
Showing 5 of 28 shared publications
Daniel A. Casciano
National Center for Toxicological Research (US)
26 shared publications
- The binding of N-hydroxy-2-acetylaminofluorene to DNA and repair of the adducts in primary rat hepatocyte cultures
- A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocytes/DNA repair assay
- Induction of stress proteins by electromagnetic fields in cultured HL-60 cells
- Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N‐acetyltransferase and glutathione S‐transferase activities
- Detoxification of carcinogenic aromatic and heterocyclic amines by enzymatic reduction of the N-hydroxy derivative
Showing 5 of 26 shared publications
Vasily N. Dobrovolsky
National Center for Toxicological Research
26 shared publications
In database
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- Genotoxicity of furan in Big Blue rats
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Evaluation of Macaca mulatta as a model for genotoxicity studies
Showing 5 of 26 shared publications
Roberta A. Mittelstaedt
National Center for Toxicological Research
16 shared publications
In database
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Genotoxicity of furan in Big Blue rats
- Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines
- Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells
Showing 5 of 16 shared publications
Ritchie J. Feuers
National Center for Toxicological Research (US)
7 shared publications
- Effects of aging and caloric restriction on the genotoxicity of four carcinogens in the in vitro rat hepatocyte/DNA repair assay
- Modifications in Regulation of Intermediary Metabolism by Caloric Restriction in Rodents
- Genotoxicity of tacrine in primary hepatocytes isolated from B6C3F1 mice and aged ad libitum and calorie restricted Fischer 344 rats
- p53 synthesis and phosphorylation in the aging diet-restricted rat following retinoic acid administration
- A circadian study of liver antioxidant enzyme systems of female Fischer-344 rats subjected to dietary restriction for six weeks.
Showing 5 of 7 shared publications
Suzanne M. Morris
National Center for Toxicological Research (US)
7 shared publications
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
Showing 5 of 7 shared publications
Daniel R. Doerge
National Center for Toxicological Research
6 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Genotoxicity of furan in Big Blue rats
- DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
Showing 5 of 6 shared publications
Mugimane G. Manjanatha
National Center for Toxicological Research
6 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- Molecular analysis of lacI mutations in Rat2TM cells exposed to 7,12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
Showing 5 of 6 shared publications
Javed A. Bhalli
National Center for Toxicological Research
6 shared publications
In database
- Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens
- Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, Aristolochic acids
Showing 5 of 6 shared publications
Frederick A. Beland
National Center for Toxicological Research
5 shared publications
In database
- Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice
- The binding of N-hydroxy-2-acetylaminofluorene to DNA and repair of the adducts in primary rat hepatocyte cultures
- DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide
- Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine
- Analysis of mutations in the Tk gene of Tk+/− mice treated as neonates with 3′-azido-3′-deoxythymidine (AZT)
Mason G. Pearce
National Center for Toxicological Research
5 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens
- Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, Aristolochic acids
Daishiro Miura
Teijin (Japan) (JP)
5 shared publications
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- Analysis of mutations in the Pig‐a gene of spleen T‐cells from N‐ethyl‐N‐nitrosourea‐treated fisher 344 rats
- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes
- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes
- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes
Sharon D. Shelton
National Center for Toxicological Research
4 shared publications
In database
- Molecular analysis of lacI mutations in Rat2TM cells exposed to 7,12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks
Donald R. Mattison
Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
4 shared publications
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks
James L. Pipkin
National Center for Toxicological Research (US)
4 shared publications
- Induction of stress proteins by electromagnetic fields in cultured HL-60 cells
- p53 synthesis and phosphorylation in the aging diet-restricted rat following retinoic acid administration
- A circadian study of liver antioxidant enzyme systems of female Fischer-344 rats subjected to dietary restriction for six weeks.
- The relationship of p53 and stress proteins in response to bleomycin and retinoic acid in the p53 heterozygous mouse
Similar Researchers
Based on overlapping research topics
Roberta A. Mittelstaedt
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Pharmacological Effects and Toxicity Studies
Becky Divine
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies
C. J. Branscomb
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
Robert H. Heflich
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Pharmacological Effects and Toxicity Studies
Michelle E. Bishop
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Pharmacological Effects and Toxicity Studies
Kamela Mitchell
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Metabolism and Genetic Disorders
Pharmacological Effects and Toxicity Studies