Biography and Research Information
OverviewAI-generated summary
Roberta A. Mittelstaedt's research focuses on the mutagenicity and genotoxicity of chemical substances, employing a range of in vitro and in vivo models. Her work investigates the mechanisms by which compounds can induce genetic damage, utilizing assays such as the CometChip, Duplex Sequencing, and the Ames test to assess DNA damage and mutagenesis.
Mittelstaedt has published studies examining the genotoxicity of specific compounds, including N-nitrosamines and N-nitroso propranolol, and has explored methods for optimizing their detection. Her research also extends to evaluating dose-response relationships for genotoxicity in different life stages and target tissues, as demonstrated by her work with ethyl methane sulfonate. She has investigated toxicokinetic and genotoxicity profiles following various exposure routes, such as inhalation, injection, and oral gavage, in rodent models like Sprague Dawley rats.
Her collaborators at the National Center for Toxicological Research include Robert H. Heflich, Nan Mei, Xuefei Cao, and Joseph G. Shaddock. Mittelstaedt's scholarship metrics include an h-index of 25, with 64 total publications and 1,732 total citations. She is recognized as a highly cited researcher.
Metrics
- h-index: 25
- Publications: 64
- Citations: 1,745
Selected Publications
-
Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes (2025)
-
Optimizing the detection of N-nitrosamine mutagenicity in the Ames test (2024)
-
Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024)
-
Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
-
Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity (2021)
-
Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing (2021)
-
Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)
-
Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking (2021)
Collaboration Network
Top Collaborators
Robert H. Heflich
National Center for Toxicological Research
7 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
Showing 5 of 7 shared publications
Nan Mei
United States Food and Drug Administration
4 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Kelly J. Davis
National Center for Toxicological Research (US)
3 shared publications
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Xuefei Cao
United States Food and Drug Administration
3 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Joseph G. Shaddock
United States Food and Drug Administration
2 shared publications
In database
- Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking
- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes
Xiaoqing Guo
National Center for Toxicological Research
2 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking
Mason G. Pearce
United States Food and Drug Administration
2 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
Michelle E. Bishop
National Center for Toxicological Research
2 shared publications
In database
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
Rebecca Wynne
United States Food and Drug Administration
2 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Ying Chen
United States Food and Drug Administration (US)
2 shared publications
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Levan Muskhelishvili
National Center for Toxicological Research (US)
2 shared publications
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Timothy W. Robison
Center for Drug Evaluation and Research (US)
2 shared publications
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Wei Sun
United States Food and Drug Administration (US)
2 shared publications
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Xilin Li
National Center for Toxicological Research (US)
2 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
Yuan Le
National Center for Toxicological Research
2 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Similar Researchers
Based on overlapping research topics
Joseph G. Shaddock
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
Matthew Bryant
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
Michelle E. Bishop
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
Javed A. Bhalli
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
Shu-Chieh Hu
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Metabolism and Genetic Disorders
Becky Divine
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications