Match tier
Likely match
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
R
Roberta A. Mittelstaedt
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
Researcher
Also affiliated: United States Food and Drug Administration (2004–2025); Thomas Jefferson National Accelerator Facility (2003); Medizinische Hochschule Hannover (1975); Forschungsinstitut Technologie und Behinderung (1998); Food and Drug Administration (2008–2021); La Roche College (1975)
Faculty Researcher
25 h-index
64 pubs
1,757 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Roberta A. Mittelstaedt's research focuses on the mutagenicity and genotoxicity of chemical substances, employing a range of in vitro and in vivo models. Her work investigates the mechanisms by which compounds can induce genetic damage, utilizing assays such as the CometChip, Duplex Sequencing, and the Ames test to assess DNA damage and mutagenesis.
Mittelstaedt has published studies examining the genotoxicity of specific compounds, including N-nitrosamines and N-nitroso propranolol, and has explored methods for optimizing their detection. Her research also extends to evaluating dose-response relationships for genotoxicity in different life stages and target tissues, as demonstrated by her work with ethyl methane sulfonate. She has investigated toxicokinetic and genotoxicity profiles following various exposure routes, such as inhalation, injection, and oral gavage, in rodent models like Sprague Dawley rats.
Her collaborators at the National Center for Toxicological Research include Robert H. Heflich, Nan Mei, Xuefei Cao, and Joseph G. Shaddock. Mittelstaedt's scholarship metrics include an h-index of 25, with 64 total publications and 1,732 total citations. She is recognized as a highly cited researcher.
Metrics
- h-index: 25
- Publications: 64
- Citations: 1,757
Selected Publications
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Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes (2025)
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Optimizing the detection of N-nitrosamine mutagenicity in the Ames test (2024)
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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024)
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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
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Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity (2021)
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Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing (2021)
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Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)
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Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking (2021)
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<scp>CD59</scp>‐deficient bone marrow erythroid cells from rats treated with procarbazine and propyl‐nitrosourea have mutations in the<i>Pig‐a</i>gene (2020)
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Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes (2019)
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Pig-a mutations in bone marrow erythroblasts of rats treated with 7,12-dimethyl-benz[a]anthracene (2019)
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Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays (2018)
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Factors affecting the<i>in vitro</i>micronucleus assay for evaluation of nanomaterials (2016)
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Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats (2015)
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Quantitative dose–response analysis of ethyl methanesulfonate genotoxicity in adult <i>gpt</i>‐delta transgenic mice (2014)
Collaboration Network
Top Collaborators
Robert H. Heflich
National Center for Toxicological Research
7 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
Showing 5 of 7 shared publications
Nan Mei
United States Food and Drug Administration
4 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Kelly J. Davis
National Center for Toxicological Research (US)
3 shared publications
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Xuefei Cao
United States Food and Drug Administration
3 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Joseph G. Shaddock
United States Food and Drug Administration
2 shared publications
In database
- Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking
- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes
Xiaoqing Guo
National Center for Toxicological Research
2 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking
Mason G. Pearce
United States Food and Drug Administration
2 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
Michelle E. Bishop
National Center for Toxicological Research
2 shared publications
In database
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
Rebecca Wynne
United States Food and Drug Administration
2 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Ying Chen
United States Food and Drug Administration
2 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Levan Muskhelishvili
National Center for Toxicological Research (US)
2 shared publications
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Timothy W. Robison
Center for Drug Evaluation and Research (US)
2 shared publications
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Wei Sun
United States Food and Drug Administration (US)
2 shared publications
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Xilin Li
National Center for Toxicological Research
2 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
Yuan Le
National Center for Toxicological Research
2 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
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