Xiaoqing Guo Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Researcher
faculty
Research Areas
Biography and Research Information
OverviewAI-generated summary
Xiaoqing Guo's research focuses on the molecular mechanisms underlying disease progression and treatment resistance, particularly in cancer and atherosclerosis. Guo has investigated the role of specific cellular components and pathways in these conditions. For instance, research has explored the function of EIF4A3-regulated circ_0087429 in reversing epithelial-mesenchymal transition and inhibiting cervical cancer progression, and has examined how TREM2 contributes to cholesterol uptake and foam cell formation in atherosclerosis.
Further work has delved into the mechanisms of cisplatin resistance in ovarian cancer, specifically investigating the contribution of CD163+ tumor-associated macrophage-derived exosomes. Guo has also been involved in studies assessing the safety and immunogenicity of SARS-CoV-2 vaccines in specific patient populations, such as those with cirrhosis.
Additionally, Guo has explored therapeutic strategies, including the use of umbilical cord blood-derived M1 macrophage exosomes loaded with cisplatin to target ovarian cancer and reverse resistance <i>in vivo</i>. Guo's scholarly output includes 181 publications, with an h-index of 34 and a total of 3,782 citations. Guo has co-authored 50 publications with another researcher named Xiaoqing Guo at the National Center for Toxicological Research.
Metrics
- h-index: 34
- Publications: 181
- Citations: 3,782
Selected Publications
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Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids (2026)
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Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025)
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Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells (2024)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Application of HepaRG cells for genotoxicity assessment: a review (2024)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models (2023)
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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
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High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing (2023)
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Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose (2022)
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Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022)
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