V
Vasily N. Dobrovolsky Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Researcher
faculty
29 h-index
106 pubs
2,556 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Vasily N. Dobrovolsky's research program investigates the detection and characterization of mutagenicity in biological systems, with a focus on employing advanced sequencing technologies. His work utilizes high-fidelity (HiFi) and PacBio sequencing to identify ultra-low-frequency substitution mutations, a critical advancement for understanding the effects of chemical mutagens in vivo and in vitro.
Dobrovolsky has published on the application of these genomic techniques to assess the mutagenic potential of compounds such as Molnupiravir and N4-hydroxycytidine. He also studies mutational signatures in specific cell types, such as T-lymphocytes in rats treated with nitrosourea and procarbazine. His research extends to establishing neural stem cell cultures from primate brains for neurotoxicity testing, indicating a broader interest in developing and applying methods for toxicological evaluation.
His collaborative network includes several colleagues at the National Center for Toxicological Research, including Page B. McKinzie, Javier R. Revollo, Jaime A. Miranda, and Robert H. Heflich, with whom he has co-authored multiple publications. Dobrovolsky's scholarly output is marked by an h-index of 29, with over 100 publications and 2,500 citations, and he is recognized as a highly cited researcher.
Metrics
- h-index: 29
- Publications: 106
- Citations: 2,556
Selected Publications
-
Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans (2026)
-
Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment (2025)
-
Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin (2024)
-
Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo (2023)
-
Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing (2023)
-
Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing (2023)
-
Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing (2022)
-
Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing (2022)
-
<scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens (2021)
-
Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine (2021)
-
<i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats (2021)
Collaboration Network
Top Collaborators
Page B. McKinzie
National Center for Toxicological Research
9 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
- Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo
Showing 5 of 9 shared publications
Javier R. Revollo
National Center for Toxicological Research
8 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- <scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
Showing 5 of 8 shared publications
Jaime A. Miranda
United States Food and Drug Administration
4 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- <scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
Mason G. Pearce
National Center for Toxicological Research
3 shared publications
In database
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
- Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans
Robert H. Heflich
National Center for Toxicological Research
3 shared publications
In database
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes
Timothy W. Robison
United States Food and Drug Administration (US)
2 shared publications
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
J. Jaime Miranda
National Center for Toxicological Research (US)
2 shared publications
- Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo
- Detecting N-ethyl-N-nitrosourea-induced mutation in the tissues of mice using whole-genome HiFi Sequencing
Stephanie L. Smith‐Roe
Triangle (US)
2 shared publications
- Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment
- Issue Information
Francesco Marchetti
Health Canada (CA)
2 shared publications
- Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment
- Issue Information
Leslie Recio
2 shared publications
- Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment
- Issue Information
Azra Dad
National Center for Toxicological Research
1 shared publication
In database
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
Alexander W. Alund
National Center for Toxicological Research
1 shared publication
In database
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
Jian Yan
United States Food and Drug Administration (US)
1 shared publication
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
Stephen D. Dertinger
Litron Laboratories (United States) (US)
1 shared publication
- Detecting N-ethyl-N-nitrosourea-induced mutation in the tissues of mice using whole-genome HiFi Sequencing
Jeffrey C. Bemis
Litron Laboratories (United States) (US)
1 shared publication
- Detecting N-ethyl-N-nitrosourea-induced mutation in the tissues of mice using whole-genome HiFi Sequencing
Similar Researchers
Based on overlapping research topics
Javier R. Revollo
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Genomics and Phylogenetic Studies
Molecular Biology Techniques and Applications
Barbara L. Parsons
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Karen L. McKim
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Genomics and Phylogenetic Studies
Molecular Biology Techniques and Applications
Azra Dad
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Genomics and Phylogenetic Studies
Pharmacological Effects and Toxicity Studies
Jaime A. Miranda
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Genomics and Phylogenetic Studies
Molecular Biology Techniques and Applications
Meagan B. Myers
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Genomics and Phylogenetic Studies
Molecular Biology Techniques and Applications