Match tier
Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
Joseph H. Holthoff
Assistant Professor
Also affiliated: University of Arkansas Medical Center (2024); University of Arkansas System (2023); Central Arkansas Veterans Healthcare System (2022–2025); Conway School of Landscape Design (2011); Arkansas Department of Agriculture (2025)
Faculty Researcher
Internal Med, College of Medicine
7 h-index
36 pubs
790 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Joseph H. Holthoff, Assistant Professor in Internal Medicine at the University of Arkansas for Medical Sciences, focuses his research on understanding and identifying biomarkers for acute kidney injury (AKI). His work has led to publications identifying SOD1 as a novel prognostic biomarker for AKI following cardiothoracic surgery and investigating urinary complement C3 and vitamin D-binding protein as predictors of adverse outcomes in similar patient populations. Holthoff also studies the role of specific molecules, such as Esm-1 and IGFBP-1, in the pathophysiology and clinical prognosis of kidney diseases, including diabetic kidney disease and AKI. His research extends to exploring unconventional therapies for challenging kidney conditions and examining the effectiveness of different dialysis methods for specific medical emergencies, such as hypermagnesemia. Holthoff collaborates with researchers at his institution, including Nithin Karakala and Fatima Ayub, with whom he has co-authored multiple publications.
Metrics
- h-index: 7
- Publications: 36
- Citations: 790
Selected Publications
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Aldosterone in Diabetic Kidney Disease: From Mineralocorticoid Receptor Antagonism to Aldosterone Synthase Inhibition (2026)
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Perfusion Under Pressure: Reversing Anuric AKI with Targeted Intra-Abdominal Pressure (IAP) Reduction (2025)
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The Second Slice Tells the Story: Evolving Cryoglobulinemia in Mesangial Glomerulonephritis (2025)
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Dialysate Sodium (2025)
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SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series (2025)
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Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy (2025)
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The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury (2025)
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Breaking Barriers: Unconventional Therapy Treats a Challenging Case of Primary Membranous Nephropathy (2024)
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New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report (2024)
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Urine Chemistry: A Valuable Link Binding Kidney Physiology to Patient Care (2024)
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Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery (2024)
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New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report (2024)
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I Am the Lucky Third: Spontaneous Resolution of High-Risk Membranous Nephropathy (2023)
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The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor (2023)
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SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery (2023)
Grants & Funding
As listed on this researcher's institutional profile.
- Investigating the mechanism of protection of IGFBP-1 in a murine model of acute kidney injury Dialysis Clinic, Inc. Principal Investigator
- Preclinical evaluation of resveratrol in sepsis-induced renal injury NIH Principal Investigator
Collaboration Network
Top Collaborators
Nithin Karakala
University of Arkansas for Medical Sciences
6 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
- Urine Chemistry: A Valuable Link Binding Kidney Physiology to Patient Care
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Showing 5 of 6 shared publications
John M. Arthur
University of Arkansas for Medical Sciences
5 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy
- Breaking Barriers: Unconventional Therapy Treats a Challenging Case of Primary Membranous Nephropathy
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
- Urine Mass Spectrometry Can Distinguish Prerenal and Intrarenal AKI
Luis A. Juncos
University of Arkansas for Medical Sciences
4 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- The Role of Esm-1 in Diabetic Kidney Disease: More Than Just a Biomarker
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
Fatima Ayub
Central Arkansas Veterans Healthcare System
4 shared publications
In database
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy
- I Am the Lucky Third: Spontaneous Resolution of High-Risk Membranous Nephropathy
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
- Dialysate Sodium
Christian Herzog
Central Arkansas Veterans Healthcare System
3 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
- Urine Mass Spectrometry Can Distinguish Prerenal and Intrarenal AKI
Md R. Hasan
Arkansas Department of Health (US)
3 shared publications
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- I Am the Lucky Third: Spontaneous Resolution of High-Risk Membranous Nephropathy
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Manisha Singh
Central Arkansas Veterans Healthcare System
3 shared publications
In database
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Yanping Izak Harville
University of Arkansas for Medical Sciences
2 shared publications
In database
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
Ahmed Abdallah
University of Arkansas for Medical Sciences (US)
2 shared publications
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- Breaking Barriers: Unconventional Therapy Treats a Challenging Case of Primary Membranous Nephropathy
Fatima Ayub
University of Arkansas for Medical Sciences
2 shared publications
In database
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- Hemodialysis Is More Effective Than Continuous Venovenous Hemodialysis for Treatment of Hypermagnesemia due to Epsom Salt Ingestion
Praveen Errabelli
Allina Health (US)
2 shared publications
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Yazan A. Bashtawi
University of Arkansas for Medical Sciences
2 shared publications
In database
- Nephrogenic Diabetes Insipidus Secondary to Foscarnet
- Hemodialysis Is More Effective Than Continuous Venovenous Hemodialysis for Treatment of Hypermagnesemia due to Epsom Salt Ingestion
Vanya Rai
Mayo Clinic in Florida (US)
2 shared publications
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report
Rajibul Hasan
University of Arkansas – Fort Smith
2 shared publications
In database
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy
- Breaking Barriers: Unconventional Therapy Treats a Challenging Case of Primary Membranous Nephropathy
Kiran Chandrashekar
Central Arkansas Veterans Healthcare System (US)
1 shared publication
- The Role of Esm-1 in Diabetic Kidney Disease: More Than Just a Biomarker
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