Lee Ann MacMillan-Crow

High Impact

Researcher

UAMS

Last publication 2026 Last refreshed 2026-05-16

faculty

31 h-index 83 pubs 9,309 cited

Research Areas

Links

ORCID Lab Website

OverviewAI-generated summary

Lee Ann MacMillan-Crow's research investigates the mechanisms of kidney injury during cold storage and transplantation, focusing on the role of oxidative stress and mitochondrial function. Her work has explored how factors like the proteasome and the OPA1 processing machinery contribute to cellular damage in renal proximal tubular cells and kidney grafts. She has also examined the protective effects of interventions such as hypothermic machine perfusion compared to static cold storage, and the impact of overexpressing manganese superoxide dismutase (MnSOD).

Further research by MacMillan-Crow delves into cellular death pathways, including the involvement of optic atrophy-1 (OPA1) processing in cardiomyocytes subjected to ischemia-reperfusion injury and the function of non-canonical cannabinoid receptors in mediating cell death in cancer cell types. She has also developed fluorescence-based assays for measuring OMA1 activity, a key enzyme in OPA1 processing.

MacMillan-Crow's scholarship metrics include an h-index of 31 and over 9,000 citations from 74 publications. She has collaborated with several researchers at the University of Arkansas for Medical Sciences, including Dinesh Bhattarai and Nirmala Parajuli, and maintains an active lab website.

Metrics

h-index: 31
Publications: 83
Citations: 9,309

Selected Publications

Compared with Static Cold Storage, Hypothermic Machine Perfusion Mitigates Oxidative Stress and Tubular Injury in Rat Kidneys (2025)

DOI OpenAlex
Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants (2024)

1 citation DOI OpenAlex
Differentiation activates mitochondrial OPA1 processing in myoblast cell lines (2024)

4 citations DOI OpenAlex
Normal Proteasome Function Is Needed to Prevent Kidney Graft Injury during Cold Storage Followed by Transplantation (2024)

2 citations DOI OpenAlex
Does Disruption of Optic Atrophy-1 (OPA1) Contribute to Cell Death in HL-1 Cardiomyocytes Subjected to Lethal Ischemia-Reperfusion Injury? (2022)

2 citations DOI OpenAlex
Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death (2022)

3 citations DOI OpenAlex
Overexpression of MnSOD Protects against Cold Storage-Induced Mitochondrial Injury but Not against OMA1-Dependent OPA1 Proteolytic Processing in Rat Renal Proximal Tubular Cells (2021)

1 citation DOI OpenAlex
Fluorescence-Based Assay For Measuring OMA1 Activity (2021)

3 citations DOI OpenAlex