Lee Ann MacMillan-Crow

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

31 h-index 74 pubs 9,257 cited

Research Areas

Mitochondrial Function and Pathology Organ Transplantation Techniques and Outcomes Receptor Mechanisms and Signaling Protein Structure and Dynamics Cancer-related molecular mechanisms research Molecular Biology Techniques and Applications Metabolomics and Mass Spectrometry Studies

Links

ORCID Lab Website

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OverviewAI-generated summary

Lee Ann MacMillan-Crow's research investigates cellular mechanisms related to cell death and organ transplantation. Her recent work has focused on the role of mitochondrial dynamics protein OPA1 in myoblast differentiation and its potential contribution to cell death in cardiomyocytes subjected to ischemia-reperfusion injury. She has also studied the impact of cold storage on the proteome and phosphoproteome landscape of rat kidney transplants, and how proteasome function influences kidney graft injury during transplantation. MacMillan-Crow has explored the protective effects of manganese superoxide dismutase (MnSOD) against cold storage-induced mitochondrial injury in renal proximal tubular cells.

Further investigations by MacMillan-Crow have examined non-canonical cannabinoid receptors and their role in mediating cell death in various cancer cell types. She has also developed fluorescence-based assays for measuring OMA1 activity. Her collaborative work includes research with Dinesh Bhattarai, Nirmala Parajuli, Julia Tobacyk, and Samuel G. Mackintosh, all from the University of Arkansas for Medical Sciences, with several shared publications across these collaborations. MacMillan-Crow maintains an active lab website and is recognized as a highly cited researcher with an h-index of 31 across 74 publications, accumulating over 9,257 citations.

Metrics

  • h-index: 31
  • Publications: 74
  • Citations: 9,257

Selected Publications

  • Compared with Static Cold Storage, Hypothermic Machine Perfusion Mitigates Oxidative Stress and Tubular Injury in Rat Kidneys (2025) DOI
  • Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants (2024) DOI
  • Differentiation activates mitochondrial OPA1 processing in myoblast cell lines (2024) DOI
  • Normal Proteasome Function Is Needed to Prevent Kidney Graft Injury during Cold Storage Followed by Transplantation (2024) DOI
  • Does Disruption of Optic Atrophy-1 (OPA1) Contribute to Cell Death in HL-1 Cardiomyocytes Subjected to Lethal Ischemia-Reperfusion Injury? (2022) DOI
  • Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death (2022) DOI
  • Overexpression of MnSOD Protects against Cold Storage-Induced Mitochondrial Injury but Not against OMA1-Dependent OPA1 Proteolytic Processing in Rat Renal Proximal Tubular Cells (2021) DOI
  • Fluorescence-Based Assay For Measuring OMA1 Activity (2021) DOI

Collaborators

Researchers in the database who share publications

Dinesh Bhattarai University of Arkansas for Medical Sciences 3 shared publications Nirmala Parajuli University of Arkansas for Medical Sciences 3 shared publications Julia Tobacyk University of Arkansas for Medical Sciences 2 shared publications Samuel G. Mackintosh University of Arkansas for Medical Sciences 1 shared publication Se-Ran Jun University of Arkansas for Medical Sciences 1 shared publication Charity L. Washam University of Arkansas for Medical Sciences 1 shared publication Gopinath Venugopal University of Arkansas for Medical Sciences 1 shared publication Seongok Lee University of Arkansas for Medical Sciences 1 shared publication

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