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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
L
Lee Ann MacMillan-Crow
High Impact
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Also affiliated: Arkansas Children's Hospital (2009); United States Food and Drug Administration (2009); University of Alabama (1999–2001); University of Arkansas Medical Center (2010); University of Alabama at Birmingham (1994–2003); Birmingham VA Medical Center (2001); UAB Medicine (1996–2003)
31 h-index
87 pubs
9,421 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Lee Ann MacMillan-Crow's research focuses on the role of oxidative stress in various disease states, with a particular emphasis on mitochondrial function. Her work has investigated the mechanisms by which reactive oxygen species, such as peroxynitrite, can damage critical cellular components, including enzymes like manganese superoxide dismutase (Mn-SOD). She has published studies examining the impact of these damaging processes in conditions such as sepsis, acetaminophen-induced hepatotoxicity, and renal ischemia/reperfusion injury.
Her investigations often utilize animal models, including rats and mice, to explore these molecular mechanisms. MacMillan-Crow's publications also address broader topics within oxidative stress research, including guidelines for assay interpretation and the involvement of Mn-SOD in disease. She has a history of collaboration with researchers at the University of Arkansas for Medical Sciences, including Dinesh Bhattarai and Nirmala Parajuli, with whom she has co-authored multiple publications.
MacMillan-Crow's scholarly output includes 85 publications, accumulating over 9,400 citations, and she maintains an h-index of 31, designating her as a highly cited researcher. Her recent activity indicates an ongoing engagement with her research interests.
Metrics
- h-index: 31
- Publications: 87
- Citations: 9,421
Selected Publications
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Heat shock protein 72 is a druggable target during cold storage to improve graft outcome after kidney transplantation (2026)
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Influence of Hypothermic Machine Perfusion on Markers of Oxidative Stress and Early Tubular Injury in Rat Donor Kidneys Before Transplantation (2026)
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Compared with Static Cold Storage, Hypothermic Machine Perfusion Mitigates Oxidative Stress and Tubular Injury in Rat Kidneys (2025)
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Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants (2024)
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Differentiation activates mitochondrial OPA1 processing in myoblast cell lines (2024)
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Normal Proteasome Function Is Needed to Prevent Kidney Graft Injury during Cold Storage Followed by Transplantation (2024)
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Does Disruption of Optic Atrophy-1 (OPA1) Contribute to Cell Death in HL-1 Cardiomyocytes Subjected to Lethal Ischemia-Reperfusion Injury? (2022)
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Inhibition of Na‐H exchanger 3 ameliorates lower limb ischemia/reperfusion‐induced acute kidney injury through preservation of mitochondrial biogenesis in mice (2022)
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Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death (2022)
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Overexpression of MnSOD Protects against Cold Storage-Induced Mitochondrial Injury but Not against OMA1-Dependent OPA1 Proteolytic Processing in Rat Renal Proximal Tubular Cells (2021)
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Fluorescence-Based Assay For Measuring OMA1 Activity (2021)
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Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats (2020)
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The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury (2020)
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Association Between L‐OPA1 Cleavage/OMA1 Activity and Cardiac Function During Ischemia‐Reperfusion Injury in the Rat (2020)
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Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage—Induced Mitochondrial Injury In Vitro (2019)
Collaboration Network
Top Collaborators
Nirmala Parajuli
University of Arkansas for Medical Sciences
22 shared publications
In database
- Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury
- Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury
- MitoQ Blunts Mitochondrial and Renal Damage during Cold Preservation of Porcine Kidneys
- Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis?
- Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse
Showing 5 of 22 shared publications
Hamida Saba
University of Arkansas for Medical Sciences (US)
14 shared publications
- Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion
- The Mitochondria-Targeted Antioxidant Mitoquinone Protects against Cold Storage Injury of Renal Tubular Cells and Rat Kidneys
- Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury
- Alteration of renal respiratory Complex-III during experimental type-1 diabetes
- Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse
Showing 5 of 14 shared publications
Philip R. Mayeux
University of Arkansas for Medical Sciences
8 shared publications
In database
- Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury
- Pharmacological targets in the renal peritubular microenvironment: Implications for therapy for sepsis-induced acute kidney injury
- Role of Mitochondrial Oxidants in an In Vitro Model of Sepsis-Induced Renal Injury
- Targeting mitochondrial oxidants may facilitate recovery of renal function during infant sepsis
- Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis.
Showing 5 of 8 shared publications
Tanecia Mitchell
University of Arkansas for Medical Sciences (US)
7 shared publications
- Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion
- The Mitochondria-Targeted Antioxidant Mitoquinone Protects against Cold Storage Injury of Renal Tubular Cells and Rat Kidneys
- Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury
- Alteration of renal respiratory Complex-III during experimental type-1 diabetes
- Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse
Showing 5 of 7 shared publications
Naeem K. Patil
University of Arkansas for Medical Sciences (US)
6 shared publications
- Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury
- Effect of S-nitrosoglutathione on renal mitochondrial function: a new mechanism for reversible regulation of manganese superoxide dismutase activity?
- Preclinical evaluation of the mitochondria‐targeted antioxidant mitoquinone to treat sepsis‐induced acute kidney injury
- Effect of S-Nitrosoglutathione On Renal Mitochondrial Function: A New Mechanism Leading To Mnsod Inactivation?
- Renal Mitochondrial Dysfunction: Unraveling the Mystery of Sepsis Induced Renal Injury
Showing 5 of 6 shared publications
Shankar Munusamy
University of Arkansas for Medical Sciences (US)
6 shared publications
- Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells
- Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion
- Alteration of renal respiratory Complex-III during experimental type-1 diabetes
- Cold Preservation Mediated Renal Injury: Involvement of Mitochondrial Oxidative Stress
- Role of manganese superoxide dismutase inactivation in the early stages of diabetic nephropathy
Showing 5 of 6 shared publications
Akira Marine
University of Arkansas for Medical Sciences (US)
5 shared publications
- MitoQ Blunts Mitochondrial and Renal Damage during Cold Preservation of Porcine Kidneys
- Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse
- Peroxynitrite induced mitochondrial biogenesis following MnSOD knockdown in normal rat kidney (NRK) cells
- Manganese Superoxide Dismutase Knockdown and Subsequent mtDNA Damage
- Cold Storage Disrupts Renal Mitochondrial Homeostasis; Mitoqunione Restores Renal Cell Mitochondrial Function
Nancy J. Rusch
University of Arkansas for Medical Sciences
5 shared publications
In database
- Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage—Induced Mitochondrial Injury In Vitro
- Abnormalities of Vascular Ion Channels During Hypertension
- MitoBK Channels as a Therapeutic Target in Renal Cold Storage and Transplantation
- Exposure to H 2 O 2 rapidly down‐regulates L‐type calcium channels in A7r5 cells
- Heat shock protein 72 is a druggable target during cold storage to improve graft outcome after kidney transplantation
Stephen Shrum
University of Arkansas for Medical Sciences
5 shared publications
In database
- Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins
- The first direct activity assay for the mitochondrial protease OMA1
- Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage—Induced Mitochondrial Injury In Vitro
- The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury
- MitoBK Channels as a Therapeutic Target in Renal Cold Storage and Transplantation
Julia Tobacyk
University of Arkansas for Medical Sciences
5 shared publications
In database
- Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins
- The first direct activity assay for the mitochondrial protease OMA1
- The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury
- Fluorescence-Based Assay For Measuring OMA1 Activity
- Overexpression of MnSOD Protects against Cold Storage-Induced Mitochondrial Injury but Not against OMA1-Dependent OPA1 Proteolytic Processing in Rat Renal Proximal Tubular Cells
Dinesh Bhattarai
University of Arkansas for Medical Sciences
5 shared publications
In database
- Normal Proteasome Function Is Needed to Prevent Kidney Graft Injury during Cold Storage Followed by Transplantation
- Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants
- Compared with Static Cold Storage, Hypothermic Machine Perfusion Mitigates Oxidative Stress and Tubular Injury in Rat Kidneys
- Influence of Hypothermic Machine Perfusion on Markers of Oxidative Stress and Early Tubular Injury in Rat Donor Kidneys Before Transplantation
- Heat shock protein 72 is a druggable target during cold storage to improve graft outcome after kidney transplantation
Robert W. Brock
University of Arkansas for Medical Sciences (US)
4 shared publications
- Alteration of renal respiratory Complex-III during experimental type-1 diabetes
- Role of manganese superoxide dismutase inactivation in the early stages of diabetic nephropathy
- NAD(P)H oxidase inhibition by gp91ds‐ tat protects against compromised parenchymal and endothelial integrity, but not flow deficits during remote liver injury
- Role of superoxide‐mediated disruption of renal mitochondria in hyperglycemia‐induced renal injury in vitro and in vivo
Jack Hinson
University of Arkansas for Medical Sciences
4 shared publications
In database
- Reactive Nitrogen Species in Acetaminophen-Induced Mitochondrial Damage and Toxicity in Mouse Hepatocytes
- The Hepatocyte Suspension Assay Is Superior to the Cultured Hepatocyte Assay for Determining Mechanisms of Acetaminophen Hepatotoxicity Relevant toin VivoToxicity
- Acetaminophen‐Induced Alterations in Hepatic Mitochondrial Manganese Superoxide Dismutase (MnSOD; SOD2) Activity in Mice
- Acetaminophen (APAP)‐Induced Hepatotoxicity and Protein Nitration in neuronal Nitric Oxide Synthase (nNOS) Knockout Mice
John P. Crow
University of Arkansas for Medical Sciences (US)
3 shared publications
- The first direct activity assay for the mitochondrial protease OMA1
- Does More MnSOD Mean More Hydrogen Peroxide?
- The Use of the Cre/ loxP System to Study Oxidative Stress in Tissue-Specific Manganese Superoxide Dismutase Knockout Models
Rakhee Agarwal
University of Arkansas for Medical Sciences (US)
3 shared publications
- New insights into the mechanisms of acetaminophen toxicity
- Acetaminophen‐Induced Alterations in Hepatic Mitochondrial Manganese Superoxide Dismutase (MnSOD; SOD2) Activity in Mice
- Acetaminophen (APAP)‐Induced Hepatotoxicity and Protein Nitration in neuronal Nitric Oxide Synthase (nNOS) Knockout Mice
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