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Last published
2024
Sources
OpenAlex · ORCID
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2026-10-06
M
Mark E. Hart
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Also affiliated: United States Food and Drug Administration (2008–2024); University of North Texas Health Science Center (1996–2002); Kansas State University (1992–1994); Mississippi State University (1987–1990)
21 h-index
38 pubs
1,776 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Mark E. Hart's research centers on the molecular mechanisms of bacterial pathogenesis, particularly in relation to *Staphylococcus aureus*. He has investigated virulence factors and regulatory systems that influence bacterial survival and disease progression. His work includes the characterization of proteins such as hyaluronidase and superoxide dismutase, and the study of global regulators like CsrA and CodY, which control the expression of numerous genes. Hart has also explored the interplay between host factors and bacterial infections, including how viral infections can prime the host for secondary bacterial pneumonia.
His research has involved diverse methodologies, from genetic manipulation and phenotypic characterization of bacterial mutants to quantitative spectrophotometric assays and advanced mass spectrometry techniques for analyzing protein profiles. Hart has also contributed to the understanding of bacterial diversity through the characterization of novel species, such as *Bacillus tequilensis*. His scholarship metrics include an h-index of 21 and over 1,700 citations, indicating a significant impact in his field. He leads a research group and has collaborated with researchers at the National Center for Toxicological Research.
Metrics
- h-index: 21
- Publications: 38
- Citations: 1,776
Selected Publications
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Directional and Strain-Specific Interaction Between Lactobacillus plantarum and Staphylococcus aureus (2024)
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CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes (2023)
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Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding (2022)
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A naturally occurring point mutation in the hyaluronidase gene (hysA1) of Staphylococcus aureus UAMS-1 results in reduced enzymatic activity (2021)
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CYPminer: an automated cytochrome P450 identification, classification, and data analysis tool for genome data sets across kingdoms (2020)
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Virulence Characteristics of mecA-Positive Multidrug-Resistant Clinical Coagulase-Negative Staphylococci (2020)
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Reduced vancomycin susceptibility and increased macrophage survival in Staphylococcus aureus strains sequentially isolated from a bacteraemic patient during a short course of antibiotic therapy (2019)
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Draft Genome Sequences of Two Staphylococcus aureus Strains Isolated in Succession from a Case of Bacteremia (2017)
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Infection of Murine Macrophages by Salmonella enterica Serovar Heidelberg Blocks Murine Norovirus Infectivity and Virus-induced Apoptosis (2015)
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Current Issues in Foodborne Illness Caused by Staphylococcus aureus (2015)
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Staphylococcus aureus Hyaluronidase Is a CodY-Regulated Virulence Factor (2014)
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Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production and Lactobacillus species growth in a defined medium simulating vaginal secretions (2014)
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Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants (2013)
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Evaluation of Virulence and Antimicrobial Resistance in Salmonella enterica Serovar Enteritidis Isolates from Humans and Chicken- and Egg-Associated Sources (2013)
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Influenza Virus Primes Mice for Pneumonia From Staphylococcus aureus (2011)
Collaboration Network
Top Collaborators
Huanli Liu
United States Food and Drug Administration (US)
4 shared publications
- Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production and Lactobacillus species growth in a defined medium simulating vaginal secretions
- Inhibition of Staphylococcus aureus by Lysostaphin-Expressing Lactobacillus plantarum WCFS1 in a Modified Genital Tract Secretion Medium
- Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants
- A naturally occurring point mutation in the hyaluronidase gene (hysA1) of Staphylococcus aureus UAMS-1 results in reduced enzymatic activity
Christopher A. Elkins
National Center for Toxicological Research (US)
3 shared publications
- Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production and Lactobacillus species growth in a defined medium simulating vaginal secretions
- Inhibition of Staphylococcus aureus by Lysostaphin-Expressing Lactobacillus plantarum WCFS1 in a Modified Genital Tract Secretion Medium
- Lactobacillus-mediated inhibition of clinical toxic shock syndrome Staphylococcus aureus strains and its relation to acid and peroxide production
Lisa Mullis
National Center for Toxicological Research
3 shared publications
In database
- Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production and Lactobacillus species growth in a defined medium simulating vaginal secretions
- Infection of Murine Macrophages by Salmonella enterica Serovar Heidelberg Blocks Murine Norovirus Infectivity and Virus-induced Apoptosis
- Lactobacillus-mediated inhibition of clinical toxic shock syndrome Staphylococcus aureus strains and its relation to acid and peroxide production
Steven L. Foley
National Center for Toxicological Research
3 shared publications
In database
- Evaluation of Virulence and Antimicrobial Resistance in Salmonella enterica Serovar Enteritidis Isolates from Humans and Chicken- and Egg-Associated Sources
- Infection of Murine Macrophages by Salmonella enterica Serovar Heidelberg Blocks Murine Norovirus Infectivity and Virus-induced Apoptosis
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
Morgan J. Hart
National Center for Toxicological Research (US)
3 shared publications
- Genotypic and Phenotypic Assessment of Hyaluronidase among Type Strains of a Select Group of Staphylococcal Species
- Genotypic and Phenotypic Assessment of Hyaluronidase among Type Strains of a Select Group of Staphylococcal Species
- Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants
Sudhakar Agnihothram
National Center for Toxicological Research (US)
3 shared publications
- Infection of Murine Macrophages by Salmonella enterica Serovar Heidelberg Blocks Murine Norovirus Infectivity and Virus-induced Apoptosis
- Reduced vancomycin susceptibility and increased macrophage survival in Staphylococcus aureus strains sequentially isolated from a bacteraemic patient during a short course of antibiotic therapy
- Draft Genome Sequences of Two Staphylococcus aureus Strains Isolated in Succession from a Case of Bacteremia
M. D. S. Basco
National Center for Toxicological Research
3 shared publications
In database
- Infection of Murine Macrophages by Salmonella enterica Serovar Heidelberg Blocks Murine Norovirus Infectivity and Virus-induced Apoptosis
- Reduced vancomycin susceptibility and increased macrophage survival in Staphylococcus aureus strains sequentially isolated from a bacteraemic patient during a short course of antibiotic therapy
- Draft Genome Sequences of Two Staphylococcus aureus Strains Isolated in Succession from a Case of Bacteremia
Hang‐Yeon Weon
National Center for Toxicological Research (US)
3 shared publications
- CYPminer: an automated cytochrome P450 identification, classification, and data analysis tool for genome data sets across kingdoms
- A naturally occurring point mutation in the hyaluronidase gene (hysA1) of Staphylococcus aureus UAMS-1 results in reduced enzymatic activity
- Directional and Strain-Specific Interaction Between Lactobacillus plantarum and Staphylococcus aureus
Sung‐Kwan Kim
University of Arkansas at Little Rock
3 shared publications
In database
- CYPminer: an automated cytochrome P450 identification, classification, and data analysis tool for genome data sets across kingdoms
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
Seong‐Jae Kim
National Center for Toxicological Research
3 shared publications
In database
- Directional and Strain-Specific Interaction Between Lactobacillus plantarum and Staphylococcus aureus
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
- CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes
Mark S. Smeltzer
University of Arkansas for Medical Sciences
2 shared publications
In database
- Molecular Basis of Pathogenicity
- Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants
Li‐Rong Yu
National Center for Toxicological Research (US)
2 shared publications
- Inhibition of Staphylococcus aureus by Lysostaphin-Expressing Lactobacillus plantarum WCFS1 in a Modified Genital Tract Secretion Medium
- Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding
Richard C. Jones
National Center for Toxicological Research (US)
2 shared publications
- Inhibition of Staphylococcus aureus by Lysostaphin-Expressing Lactobacillus plantarum WCFS1 in a Modified Genital Tract Secretion Medium
- Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants
Robin L. Stingley
National Center for Toxicological Research (US)
2 shared publications
- Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production and Lactobacillus species growth in a defined medium simulating vaginal secretions
- Lactobacillus-mediated inhibition of clinical toxic shock syndrome Staphylococcus aureus strains and its relation to acid and peroxide production
Joanna Deck
National Center for Toxicological Research
2 shared publications
In database
- Evaluation of Virulence and Antimicrobial Resistance in Salmonella enterica Serovar Enteritidis Isolates from Humans and Chicken- and Egg-Associated Sources
- Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants
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