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Likely match
Presence
Current · Arkansas
Last published
2024
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
M
Merle G. Paule
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Also affiliated: Centers for Disease Control and Prevention (2015); Arkansas Children's Hospital (1991–2012); United States Food and Drug Administration (1993–2023); Mayo Clinic (2018); Center for Drug Evaluation and Research (2015–2016); Baylor College of Medicine (2018); National Institute for Occupational Safety and Health (2015); National Research Council Canada (1986); University of California, Davis (1980–1982)
54 h-index
357 pubs
11,451 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Merle G. Paule's research investigates the neurotoxicological effects of various agents, particularly focusing on agents used in anesthesia and their impact on developing brains. Paule has published extensively on the effects of ketamine and other inhalation anesthetics on neuronal cell death and cognitive deficits in both animal models, such as rhesus monkeys and developing rats, and in the context of human pediatric exposure. This work includes studies examining dose-response relationships and the molecular mechanisms underlying anesthetic-induced neurotoxicity.
Paule's research also extends to the potential toxicity of nanoparticles, specifically silver nanoparticles, and their effect on the blood-brain barrier in rat brain microvessel endothelial cells. Collaborations with researchers at the National Center for Toxicological Research and the University of Arkansas for Medical Sciences have contributed to a publication record of over 330 papers, with an h-index of 54 and over 10,800 citations, designating Paule as a highly cited researcher. Paule has recently been active in research, with the most recent publication in 2024.
Metrics
- h-index: 54
- Publications: 357
- Citations: 11,451
Selected Publications
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Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78] (2024)
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Performance of the prospective T2 MRI biomarker of neurotoxicity in a trimethyltin model in rats at 7 T (2023)
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Discontinuation of methylphenidate after long-term exposure in nonhuman primates (2023)
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The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey (2022)
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Prenatal trace elements mixture is associated with learning deficits on a behavioral acquisition task among young children (2022)
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Sexually dimorphic associations between prenatal blood lead exposure and performance on a behavioral testing battery in children (2022)
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Prenatal metal mixture concentrations and reward motivation in children (2021)
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Sexually dimorphic associations between prenatal blood lead exposure and temporal processing in 6- to 7-year-old children in Mexico City (2021)
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MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates (2021)
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Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin (2021)
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General anaesthesia during infancy reduces white matter micro-organisation in developing rhesus monkeys (2021)
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Quantitative Neurotoxicology: An Assessment of the Neurotoxic Profile of Kainic Acid in Sprague Dawley Rats (2020)
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An Alternative In Vitro Method for Examining Nanoparticle-Induced Cytotoxicity (2019)
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Cytotoxicity profile of pristine graphene on brain microvascular endothelial cells (2019)
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Performance on the Operant Test Battery in young children exposed to procedures requiring general anaesthesia: the MASK study (2019)
Collaboration Network
Top Collaborators
William Slikker
National Center for Toxicological Research
60 shared publications
In database
- Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
- Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
Showing 5 of 60 shared publications
Syed F. Ali
National Center for Toxicological Research
48 shared publications
In database
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Mechanistic Toxicity Evaluation of Uncoated and PEGylated Single-Walled Carbon Nanotubes in Neuronal PC12 Cells
- Ketamine-Induced Neurotoxicity and Changes in Gene Expression in the Developing Rat Brain
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC)
Showing 5 of 48 shared publications
Joseph P. Hanig
Center for Drug Evaluation and Research (US)
24 shared publications
- Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
- Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys
- Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
Showing 5 of 24 shared publications
Tucker A. Patterson
National Center for Toxicological Research
23 shared publications
In database
- Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
- Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys
- Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
Showing 5 of 23 shared publications
Elvis Cuevas
National Center for Toxicological Research (US)
21 shared publications
- Zebrafish Model in Drug Safety Assessment
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Developmental toxicity assay using high content screening of zebrafish embryos
- Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish
- Acetyl l-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos
Showing 5 of 21 shared publications
Sherry A. Ferguson
National Center for Toxicological Research (US)
21 shared publications
- A pilot study of preemptive morphine analgesia in preterm neonates: Effects on head circumference, social behavior, and response latencies in early childhood
- Attention deficit/hyperactivity disorder: characteristics, interventions and models
- Baseline behavior, but not sensitivity to stimulant drugs, differs among Spontaneously Hypertensive, Wistar–Kyoto, and Sprague–Dawley rat strains
- Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate
- Neonatal dexamethasone on Day 7 in rats causes behavioral alterations reflective of hippocampal, but not cerebellar, deficits
Showing 5 of 21 shared publications
John J. Chelonis
Arkansas Children's Hospital
20 shared publications
In database
- Attention deficit/hyperactivity disorder: characteristics, interventions and models
- Neurodevelopment of children exposed to anesthesia: Design of the Mayo Anesthesia Safety in Kids (MASK) study
- Conference
- Symposium Overview
- Developmental aspects of delayed matching-to-sample task performance in children
Showing 5 of 20 shared publications
Glenn D. Newport
National Center for Toxicological Research
17 shared publications
In database
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Developmental toxicity assay using high content screening of zebrafish embryos
- In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography
- Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate
Showing 5 of 17 shared publications
Richard R. Allen
National Center for Toxicological Research (US)
17 shared publications
- Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys
- Chronic marijuana smoke exposure in the rhesus monkey. II: Effects on progressive ratio and conditioned position responding.
- Monkey versus human performance in the NCTR operant test battery
- Acute behavioral effects of MK-801 in rhesus monkeys: Assessment using an operant test battery
- Behavioral and neurochemical effects of chronic methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys
Showing 5 of 17 shared publications
Cheng Wang
National Center for Toxicological Research
17 shared publications
In database
- Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
- Ketamine-Induced Neurotoxicity and Changes in Gene Expression in the Developing Rat Brain
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
- Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage
Showing 5 of 17 shared publications
Susan M. Lantz
National Center for Toxicological Research
16 shared publications
In database
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Mechanistic Toxicity Evaluation of Uncoated and PEGylated Single-Walled Carbon Nanotubes in Neuronal PC12 Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Brain microvessel endothelial cells responses to gold nanoparticles:In vitropro-inflammatory mediators and permeability
- In vivo imaging and quantitative analysis of changes in axon length using transgenic zebrafish embryos
Showing 5 of 16 shared publications
Michael Gillam
National Center for Toxicological Research (US)
15 shared publications
- Acute behavioral effects of MK-801 in rhesus monkeys: Assessment using an operant test battery
- Behavioral and neurochemical effects of chronic methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys
- Acute behavioral effects of phencyclidine on rhesus monkey performance in an operant test battery
- Acute effects of methylenedioxymethamphetamine (MDMA) on several complex brain functions in monkeys
- Acute Effects of Dexfenfluramine (d‐FEN) and Methylenedioxymethamphetamine (MDMA) before and after Short‐Course, High‐Dose Treatment
Showing 5 of 15 shared publications
Sumit Sarkar
National Center for Toxicological Research
14 shared publications
In database
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- The use of MRI to assist the section selections for classical pathology assessment of neurotoxicity
- Protein Kinases and Parkinson’s Disease
- Chronic exposure to rotenone, a dopaminergic toxin, results in peripheral neuropathy associated with dopaminergic damage
Showing 5 of 14 shared publications
Natalya Sadovova
National Center for Toxicological Research
14 shared publications
In database
- Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
- Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
- The effects of l-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex
- Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells
Showing 5 of 14 shared publications
Charles M. Fogle
National Center for Toxicological Research
13 shared publications
In database
- Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells
- Baseline behavior, but not sensitivity to stimulant drugs, differs among Spontaneously Hypertensive, Wistar–Kyoto, and Sprague–Dawley rat strains
- Effects of Acute Nicotine on Several Operant Behaviors in Rats
- Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometry
- Similar effects of amphetamine and methylphenidate on the performance of complex operant tasks in rats
Showing 5 of 13 shared publications
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