Fang Liu
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Also affiliated: United States Food and Drug Administration (2010–2025); Centre for Addiction and Mental Health (2007–2025); Shanghai Medical College of Fudan University (2012–2013); Guiyang Medical University (2011); University of Georgia (2022); Henan University (2025); Iowa State University (1991–1996); Second Military Medical University (2012); Shanxi University (2024); University of Toronto (2007–2017); Jilin University (2024); Cornell University (1996); Fudan University (2009–2015); Augusta University (2022); AntiCancer (United States) (2012); First Hospital of Jilin University (2013–2024); Yueyang Second People's Hospital (2018); State Key Laboratory of Medical Neurobiology (2009–2015); Campbell Family Mental Health Research Institute (2015–2025); Henan Agricultural University (2025); Southern Medical University (2025)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Fang Liu's research centers on neurotoxicity, particularly the effects of anesthetic agents on the developing brain. Her work has investigated ketamine-induced neurotoxicity and alterations in gene expression and N-methyl-D-aspartate receptor function in rat models. Liu has also studied neuronal damage in developing rhesus monkeys due to inhalation anesthetics.
Beyond anesthetic-related neurotoxicity, Liu's research has explored fundamental aspects of neurobiology. This includes the identification and characterization of neuroblasts in the adult human brain and the subcortical origins of neocortical interneurons. Her work also touches on the interaction between dopamine transporters and dopamine D2 receptors.
Liu is a highly cited researcher with an h-index of 26 and over 2,700 citations across 89 publications. She leads a research group and collaborates with several colleagues at the National Center for Toxicological Research, including Leah E. Latham, Tucker A. Patterson, and Shuliang Liu.
Metrics
- h-index: 26
- Publications: 86
- Citations: 2,816
Selected Publications
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Regulating controlled substances to advance research and protect public health (2026)
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Assessing the developmental effects of fentanyl and impacts on lipidomic profiling using neural stem cell models (2025)
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The effects of cannabidiol and its main metabolites on human neural stem cells (2025)
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Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models (2025)
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Biomarkers of Neurotoxicity and Disease (2025)
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Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety (2024)
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Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing (2023)
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Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain (2023)
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The NMDA Receptor System and Developmental Neurotoxicity (2022)
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Phencyclidine (PCP)-induced neurotoxicity and behavioral deficits (2022)
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The NMDA Receptor System and Developmental Neurotoxicity (2021)
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Neuroprotective Effects of Carnitine and Its Potential Application to Ameliorate Neurotoxicity (2021)
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Application of microRNA profiling to understand sevoflurane-induced adverse effects on developing monkey brain (2020)
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Neurotoxicity of drug of abuse (2020)
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Potential mechanisms for phencyclidine/ketamine-induced brain structural alterations and behavioral consequences (2019)
Collaboration Network
Top Collaborators
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
- Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage
- Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells
- Relationship between ketamine-induced developmental neurotoxicity and NMDA receptor-mediated calcium influx in neural stem cell-derived neurons
Showing 5 of 28 shared publications
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
- Ketamine-Induced Neurotoxicity and Changes in Gene Expression in the Developing Rat Brain
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
- Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage
- Relationship between ketamine-induced developmental neurotoxicity and NMDA receptor-mediated calcium influx in neural stem cell-derived neurons
Showing 5 of 25 shared publications
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
- Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage
- Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells
- Relationship between ketamine-induced developmental neurotoxicity and NMDA receptor-mediated calcium influx in neural stem cell-derived neurons
Showing 5 of 22 shared publications
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
- Ketamine-Induced Neurotoxicity and Changes in Gene Expression in the Developing Rat Brain
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
- Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage
- Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells
Showing 5 of 17 shared publications
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
- Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure
- Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-Derived Models
- Effects of Xenon-Based Anesthetic Exposure on the Expression Levels of Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) on Human Neural Stem Cell–Derived Neurons
Showing 5 of 16 shared publications
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
- Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells
- Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells
- Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure
Showing 5 of 14 shared publications
- Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
- MicroPET/CT Imaging of [ 18 F]-FEPPA in the Nonhuman Primate: A Potential Biomarker of Pathogenic Processes Associated with Anesthetic-Induced Neurotoxicity
- Application of advanced preclinical models and methods in anesthetic neurotoxicity research
- Approaches and Models for Evaluating the Toxic Effects of Anesthetics in the Developing Nervous System
Showing 5 of 8 shared publications
- Neuroprotective Effects of Carnitine and Its Potential Application to Ameliorate Neurotoxicity
- The effects of cannabidiol and its main metabolites on human neural stem cells
- Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain
- Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing
- Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models
Showing 5 of 7 shared publications
- The Role of Autophagy in Usnic Acid-Induced Toxicity in Hepatic Cells
- ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells
- Mechanisms of tolvaptan-induced toxicity in HepG2 cells
- Phototoxicity of Kava — Formation of Reactive Oxygen Species Leading to Lipid Peroxidation and DNA Damage
- Inhalation Anesthesia-Induced Neuronal Damage and Gene Expression Changes in Developing Rat Brain
- Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage
- Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells
- Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells
- Inhalation Anesthesia-Induced Neuronal Damage and Gene Expression Changes in Developing Rat Brain
- Lipidomics Reveals Changes in Metabolism, Indicative of Anesthetic-Induced Neurotoxicity in Developing Brains
- Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture
- Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells
- Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells
- Inhalation Anesthesia-Induced Neuronal Damage and Gene Expression Changes in Developing Rat Brain
- Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells
- Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-Derived Models
- Effects of Xenon-Based Anesthetic Exposure on the Expression Levels of Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) on Human Neural Stem Cell–Derived Neurons
- Application of microRNA profiling to understand sevoflurane-induced adverse effects on developing monkey brain
- Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells
- Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-Derived Models
- Assessing the developmental effects of fentanyl and impacts on lipidomic profiling using neural stem cell models
- Biomarkers of Neurotoxicity and Disease
- Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage
- Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure
- Lipidomics Reveals Changes in Metabolism, Indicative of Anesthetic-Induced Neurotoxicity in Developing Brains
- Identifying Potential Biomarkers, Mechanisms and Protective Strategies for General Anesthetic‐Induced Neurotoxicity in the Developing Nonhuman Primate
- Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure
- Application of microRNA profiling to understand sevoflurane-induced adverse effects on developing monkey brain
- The effects of cannabidiol and its main metabolites on human neural stem cells
- Identifying Potential Biomarkers, Mechanisms and Protective Strategies for General Anesthetic‐Induced Neurotoxicity in the Developing Nonhuman Primate
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