Mulu Z. Tesfay

Assistant Professor

University of Arkansas for Medical Sciences

faculty

COM | Pathology Research Faculty

8 h-index 29 pubs 427 cited

Research Areas

Pancreatic and Hepatic Oncology Research Cancer Immunotherapy and Biomarkers Virus-based gene therapy research Immune Response and Inflammation Microbial infections and disease research SARS-CoV-2 and COVID-19 Research

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OverviewAI-generated summary

Mulu Z. Tesfay's research focuses on developing novel therapeutic strategies for cancer, particularly pancreatic cancer. His work investigates the tumor microenvironment as a significant barrier and target for treatment. Tesfay has explored the repurposing of existing vaccines, such as the MMR vaccine, for cancer immunotherapy. He also studies the use of oncolytic viruses, engineered to target and destroy cancer cells, in combination with other treatments like immune checkpoint blockade, to enhance treatment effectiveness in various cancers including hepatocellular carcinoma and pancreatic ductal adenocarcinoma.

Additionally, Tesfay has contributed to research on viral immunity, including studies on boosting SARS-CoV-2 immunity in nonhuman primates using oral vaccines. His scholarship metrics include an h-index of 8 with 427 total citations across 29 publications. Key collaborators include Khandoker Usran Ferdous, Martin J. Cannon, Alexei G. Basnakian, and Steven R. Post, with whom he has multiple shared publications.

Metrics

  • h-index: 8
  • Publications: 29
  • Citations: 427

Selected Publications

  • CMTM6-Silencing Microbial Immunotherapy Reprograms PDAC Tumors and Restores T-cell Function (2026) DOI
  • Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025) DOI
  • Abstract B022: Reprogramming Apoptotic Resistance in PDAC Through Synthetic Oncolytic Immunotherapy (2025) DOI
  • Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response (2025) DOI
  • Viral warfare: unleashing engineered oncolytic viruses to outsmart cancer’s defenses (2025) DOI
  • Abstract 950: Engineered oncolytic vesiculovirus downsizes pancreatic tumor and boosts immune response (2025) DOI
  • Abstract 2155: Phage display discovery of Trop-2 peptide for targeted liposomal chemo-immunotherapy in lung cancer (2025) DOI
  • Abstract 945: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2025) DOI
  • Abstract 947: Engineering a synthetic oncolytic virus to overcome apoptotic resistance and induce immunogenic cell death in pancreatic ductal adenocarcinoma (2025) DOI
  • Resistance signatures to oncolytic vesiculoviruses in pancreatic ductal adenocarcinoma (2025) DOI
  • Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade (2024) DOI
  • Abstract B049: Oncolytic virotherapy as an effective tool to synergistically enhance therapeutic efficacy of standard systemic treatments for pancreatic cancer (2024) DOI
  • Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer (2024) DOI
  • Abstract 588: Preclinical evaluation of novel chimeric vesiculovirus mediated expression of proteolytic enzymes targeting two major stromal components of pancreatic ductal adenocarcinoma (2024) DOI
  • Abstract 5004: Oncolytic Jurona-driven systemic and intratumoral immunotherapy combined with immune checkpoint blockade boost immune response and survival in hepatocellular carcinoma models (2024) DOI

Grants & Funding

  • Underrepresented Populations Fellowship in Cell and Gene Therapy American Society of Gene + Cell Therapy (ASGCT) Principal Investigator

Collaborators

Researchers in the database who share publications

Khandoker Usran Ferdous University of Arkansas for Medical Sciences 14 shared publications Martin J. Cannon University of Arkansas for Medical Sciences 10 shared publications Alexei G. Basnakian Arkansas State University 10 shared publications Steven R. Post University of Arkansas for Medical Sciences 9 shared publications Camila Simões University of Arkansas for Medical Sciences 9 shared publications Bolni Marius Nagalo University of Arkansas for Medical Sciences 9 shared publications Bahaa Mustafa University of Arkansas for Medical Sciences 8 shared publications Randal S. Shelton University of Arkansas for Medical Sciences 6 shared publications

Similar Researchers

Based on overlapping research topics

Martin J. Cannon University of Arkansas for Medical Sciences
Pancreatic and Hepatic Oncology Research Cancer Immunotherapy and Biomarkers Virus-based gene therapy research
Good match 5 shared topics
Bahaa Mustafa University of Arkansas for Medical Sciences
Pancreatic and Hepatic Oncology Research Cancer Immunotherapy and Biomarkers Immune Response and Inflammation
Good match 5 shared topics
Camila Simões University of Arkansas for Medical Sciences
Pancreatic and Hepatic Oncology Research Cancer Immunotherapy and Biomarkers Virus-based gene therapy research
Good match 4 shared topics
Timothy Muren University of Arkansas for Medical Sciences
Virus-based gene therapy research Immune Response and Inflammation Microbial infections and disease research
Good match 3 shared topics
Aditya Boddu University of Arkansas for Medical Sciences
Immune Response and Inflammation Microbial infections and disease research SARS-CoV-2 and COVID-19 Research
Good match 3 shared topics
Hui-Yong Chung University of Arkansas for Medical Sciences
Immune Response and Inflammation Microbial infections and disease research SARS-CoV-2 and COVID-19 Research
Good match 3 shared topics