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Presence Current · Arkansas
Last published 2025
Sources OpenAlex · ORCID
Refreshed 2026-08-15

Narasimhappagari Jagadeesh

Researcher

Also affiliated: Karnatak University (2018–2022); Dongguk University (2020); Indian Institute of Science Bangalore (2018)

Faculty Researcher

6 h-index 17 pubs 108 cited

  • Humans
  • Lectins
  • Antineoplastic Agents
  • Cell Proliferation
  • Alzheimer Disease
  • Signal Transduction
  • Cell Line, Tumor
  • Interleukin-1beta
  • Fucose
  • Keratitis
  • Apoptosis
  • Animals
  • Autophagy
  • Mice
  • Apolipoprotein E4

Biography and Research Information

OverviewAI-generated summary

Narasimhappagari Jagadeesh's research investigates the molecular mechanisms underlying various diseases, with a particular focus on cancer and neurodegenerative disorders. His work has explored the anti-cancer activities of lectins derived from fungi and plants, examining their ability to induce apoptosis in cancer cell lines. Jagadeesh has also studied the role of specific cytokines, such as Interleukin-1 beta (IL-1β), in the pathogenesis of glioblastoma and Alzheimer's disease, and has investigated potential therapeutic interventions targeting these pathways. His research also extends to fungal infections, including the investigation of lectin involvement in mycotic keratitis. Jagadeesh has published 17 papers, accumulating 97 citations, and holds an h-index of 6. He has collaborated with researchers including W. Sue T. Griffin, Srinivas Ayyadevara, and Meenakshisundaram Balasubramaniam at the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 6
  • Publications: 17
  • Citations: 108

Selected Publications

  • When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis (2025)
    Cells 1 citation DOI OpenAlex
  • The Seminal Role of the Proinflammatory Cytokine IL-1β and Its Signaling Cascade in Glioblastoma Pathogenesis and the Therapeutic Effect of Interleukin-1β Receptor Antagonist (IL-1RA) and Tolcapone (2025)
    International Journal of Molecular Sciences 7 citations DOI OpenAlex
  • Abstract LB131: The role of the proinflammatory cytokine IL-1β and its signaling cascade in glioblastoma pathogenesis and the therapeutic effect of IL-1RA and Tolcapone as anticancer agents (2025)
    Cancer Research 1 citation DOI OpenAlex
  • Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024)
    Communications Biology 21 citations DOI OpenAlex

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Collaboration Network

13 Collaborators 6 Institutions 1 Country

Top Collaborators

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