Match tier
Likely match
Presence
Current · Arkansas
Last published
2024
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
Q
Qingsu Xia
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
Researcher
Also affiliated: Center for Food Safety and Applied Nutrition (2005); United States Food and Drug Administration (2005–2024); Chinese University of Hong Kong (2004); Biochemical Society (2014)
Faculty Researcher
35 h-index
98 pubs
5,496 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Qingsu Xia investigates the molecular mechanisms underlying the carcinogenicity of pyrrolizidine alkaloids (PAs) and their role in human liver cancer. His research focuses on the formation of DNA and protein adducts resulting from the metabolism of PAs, which are found in various plant species and can contaminate food and dietary supplements. Xia has published research detailing how these adducts contribute to tumor development, utilizing techniques such as mutational signature analysis and the development of non-invasive biomarkers in urine and blood for early detection of PA-induced liver injury.
His work also explores protective mechanisms against PA-induced hepatotoxicity. In collaboration with researchers such as Xiaobo He and Matthew Bryant at the National Center for Toxicological Research, Xia has investigated how compounds like liquorice extract can mitigate PA-induced liver damage by inhibiting the metabolic activation of PAs. This research involves studies in animal models, including rats and mice, to understand the correlation between specific adducts and tumorigenic risk. Xia's scholarship includes 98 publications with over 5,400 citations and an h-index of 35.
Metrics
- h-index: 35
- Publications: 98
- Citations: 5,496
Selected Publications
-
An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts (2024)
-
Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements (2023)
-
Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid (2022)
-
Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation (2022)
-
Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid<i>N</i>-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts (2021)
-
Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human (2021)
-
Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury (2021)
-
Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer (2021)
-
1-Formyl-7-hydroxy-6,7-dihydro-5<i>H</i>-pyrrolizine (1-CHO–DHP)–Cysteine Conjugates: Metabolic Formation and Binding to Cellular DNA (2020)
-
Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes (2020)
-
Quantitation of DNA reactive pyrrolic metabolites of senecionine – A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis (2019)
-
1-Formyl-7-hydroxy-6,7-dihydro-5<i>H</i>-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids (2019)
-
1‐Formyl‐7‐hydroxy‐6,7‐dihydro‐5 <i>H</i> ‐pyrrolizine (9‐CHO‐DHP) ‐ A Biologically Proximate Pyrrolic Metabolite of Carcinogenic Pyrrolizidine Alkaloids (2018)
-
Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells (2018)
-
Pyrrole-protein adducts – A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity (2018)
Collaboration Network
Top Collaborators
Peter P. Fu
United States Food and Drug Administration (US)
8 shared publications
- Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer
- Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation
- Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury
- Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human
- Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid
Showing 5 of 8 shared publications
Yisheng He
Chinese University of Hong Kong (CN)
6 shared publications
- Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer
- Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation
- Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury
- Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human
- Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid
Showing 5 of 6 shared publications
Ge Lin
Chinese University of Hong Kong (CN)
6 shared publications
- Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer
- Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation
- Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury
- Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human
- Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid
Showing 5 of 6 shared publications
Lin Zhu
Chinese University of Hong Kong (CN)
5 shared publications
- Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer
- Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury
- Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human
- Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid
- Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements
Jiang Ma
Chinese University of Hong Kong (CN)
4 shared publications
- Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer
- Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation
- Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury
- Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human
Xiaobo He
National Center for Toxicological Research
3 shared publications
In database
- Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid<i>N</i>-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts
- Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements
- An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts
Chunyuan Zhang
Chinese University of Hong Kong (CN)
2 shared publications
- Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury
- Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human
Yang Ye
Chinese Academy of Sciences (CN)
2 shared publications
- Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation
- Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury
Yuzheng Zhuge
Nanjing Drum Tower Hospital (CN)
2 shared publications
- Blood Pyrrole–DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury
- Developing urinary pyrrole–amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human
Matthew Bryant
National Center for Toxicological Research
2 shared publications
In database
- Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements
- An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts
Mai Shi
Chinese University of Hong Kong (CN)
1 shared publication
- Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer
Xu Wu
Chinese University of Hong Kong (CN)
1 shared publication
- Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer
TP Ng
University of Hong Kong (HK)
1 shared publication
- Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer
Kwan Man
University of Hong Kong (HK)
1 shared publication
- Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer
Stephen Kwok‐Wing Tsui
Chinese University of Hong Kong (CN)
1 shared publication
- Mutational Signature Analysis Reveals Widespread Contribution of Pyrrolizidine Alkaloid Exposure to Human Liver Cancer
Similar Researchers
Based on overlapping research topics
H. J. Chen
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Drug-Induced Hepatotoxicity and Protection
Metabolism and Genetic Disorders
Madison Blue
University of Arkansas for Medical Sciences
Drug-Induced Hepatotoxicity and Protection
Metabolism and Genetic Disorders
Liver Disease Diagnosis and Treatment
Mackean P. Maisha
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Drug-Induced Hepatotoxicity and Protection
Cancer-related molecular mechanisms research
Xiaobo He
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Drug-Induced Hepatotoxicity and Protection
Metabolism and Genetic Disorders
Ji‐Eun Seo
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Drug-Induced Hepatotoxicity and Protection
Cancer-related molecular mechanisms research
Jake R. Price
University of Arkansas for Medical Sciences
Drug-Induced Hepatotoxicity and Protection
Metabolism and Genetic Disorders
Liver Disease Diagnosis and Treatment