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Xiaobo He Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Researcher
faculty
15 h-index
49 pubs
561 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Xiaobo He's research focuses on the genotoxicity and metabolism of various chemical compounds, employing both in vitro and in vivo models. His work has investigated the role of cytochrome P450 enzymes in the metabolic activation and cytotoxicity of substances like pyrrolizidine alkaloids, nitrosamine impurities, and lapatinib. He has utilized human lymphoblastoid TK6 cells and primary hepatocytes from rats and rhesus macaques to assess DNA adduct formation and cellular toxicity. His recent publications also include pharmacokinetic analysis of nicotine metabolites in rats and the evaluation of a human placental barrier model for drug transfer studies. He has published 49 papers, accumulating 549 citations and an h-index of 15. He collaborates with researchers at the National Center for Toxicological Research, including Matthew Bryant, Nan Mei, Ji-Eun Seo, and Xilin Li.
Metrics
- h-index: 15
- Publications: 49
- Citations: 561
Selected Publications
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Mechanistic study of pexidartinib-induced toxicity in human hepatic cells (2025)
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Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025)
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Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025)
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An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts (2024)
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Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024)
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Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024)
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Evaluation of a microphysiological human placental barrier model for studying placental drug transfer (2023)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements (2023)
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Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022)
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Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid<i>N</i>-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts (2021)
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Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021)
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The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells (2021)
Collaboration Network
Top Collaborators
Matthew Bryant
National Center for Toxicological Research
10 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
Showing 5 of 10 shared publications
Nan Mei
Genetic Analysis (Norway)
7 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Showing 5 of 7 shared publications
Xiaoqing Guo
United States Food and Drug Administration
5 shared publications
In database
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
Si Chen
Biochemical Society
4 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
- Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing
Lei Guo
Biochemical Society
4 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
- Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing
Ji‐Eun Seo
National Center for Toxicological Research
3 shared publications
In database
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Qingsu Xia
United States Food and Drug Administration
3 shared publications
In database
- Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid<i>N</i>-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts
- Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements
- An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts
Peter P. Fu
United States Food and Drug Administration (US)
3 shared publications
- Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid<i>N</i>-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts
- Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements
- An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts
Xilin Li
United States Food and Drug Administration
3 shared publications
In database
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
Yuan Le
National Center for Toxicological Research
2 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
Aisar Atrakchi
United States Food and Drug Administration (US)
2 shared publications
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Timothy J. McGovern
United States Food and Drug Administration (US)
2 shared publications
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Robert H. Heflich
United States Food and Drug Administration
2 shared publications
In database
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Xilin Li
Genetic Analysis (Norway) (NO)
2 shared publications
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Yuxi Li
Biochemical Society (GB)
2 shared publications
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells
Similar Researchers
Based on overlapping research topics
Matthew Bryant
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Metabolism and Genetic Disorders
Ji‐Eun Seo
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Metabolism and Genetic Disorders
Lawrence Grylack
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Molecular Biology Techniques and Applications
H. J. Chen
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Metabolism and Genetic Disorders
Nan Mei
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Metabolism and Genetic Disorders
Lei Guo
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Metabolism and Genetic Disorders