Ji‐Eun Seo Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

National Center for Toxicological Research

faculty

14 h-index 33 pubs 438 cited

Research Areas

Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications Cancer-related molecular mechanisms research Genomics and Phylogenetic Studies Metabolomics and Mass Spectrometry Studies Effects of Environmental Stressors on Livestock Plant Physiology and Cultivation Studies

Links

ORCID Lab Website

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OverviewAI-generated summary

Ji-Eun Seo's research centers on evaluating the mutagenicity and genotoxicity of various chemical compounds using in vitro cell models. She has published studies investigating the genotoxicity of nitrosamines, including N-nitroso propranolol and N-nitrosodimethylamine, utilizing both traditional 2D cell cultures and advanced 3D HepaRG spheroid models. Her work also explores the application of high-throughput assays, such as the micronucleus assay and the CometChip platform, for efficient genotoxicity testing. Seo has investigated the role of hepatic cytochrome P450 enzymes in drug cytotoxicity, specifically in relation to lapatinib. Her scholarship metrics include an h-index of 14, with 33 total publications and 438 total citations. She has collaborated extensively with researchers at the National Center for Toxicological Research, including Nan Mei, Robert H. Heflich, Matthew Bryant, and Xiaobo He.

Metrics

  • h-index: 14
  • Publications: 33
  • Citations: 438

Selected Publications

  • Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen (2025) DOI
  • Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing (2025) DOI
  • Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025) DOI
  • Review of black cohosh-induced toxicity and adverse clinical effects (2025) DOI
  • Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025) DOI
  • Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities (2025) DOI
  • Isolation and Cryopreservation of Primary Macaque Hepatocytes (2024) DOI
  • Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024) DOI
  • Application of HepaRG cells for genotoxicity assessment: a review (2024) DOI
  • The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023) DOI
  • Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models (2023) DOI
  • Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023) DOI
  • High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing (2023) DOI
  • Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform (2022) DOI
  • Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021) DOI

Collaborators

Researchers in the database who share publications

Nan Mei National Center for Toxicological Research 8 shared publications Robert H. Heflich National Center for Toxicological Research 6 shared publications Matthew Bryant National Center for Toxicological Research 3 shared publications Xiaobo He National Center for Toxicological Research 3 shared publications Pritpal Malhi National Center for Toxicological Research 3 shared publications Yuan Le National Center for Toxicological Research 3 shared publications Javier R. Revollo National Center for Toxicological Research 2 shared publications Jaime A. Miranda National Center for Toxicological Research 2 shared publications

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