J
Ji‐Eun Seo Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Researcher
faculty
14 h-index
27 pubs
457 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Ji-Eun Seo's research focuses on assessing the mutagenicity and genotoxicity of various compounds, particularly nitrosamines, using in vitro cell models. Her work has involved the application of advanced techniques, including high-throughput assays and next-generation sequencing, to evaluate the potential DNA damage caused by these substances. Seo has investigated the utility of three-dimensional HepaRG spheroids as a model system for genotoxicity testing, comparing their effectiveness to traditional two-dimensional cell cultures.
Her publications also explore the role of specific cellular components, such as hepatic cytochrome P450s, in the cytotoxicity of drugs like lapatinib. Seo has a history of collaboration with researchers at the National Center for Toxicological Research, including Nan Mei and Robert H. Heflich, with whom she has co-authored multiple publications. Her research contributes to the understanding of chemical safety and the development of more predictive in vitro testing methods.
Metrics
- h-index: 14
- Publications: 27
- Citations: 457
Selected Publications
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Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids (2026)
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Mutagenicity of <i>N</i> -nitroso-fluoxetine and <i>N</i> -nitroso-varenicline in human HepaRG cell models (2026)
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Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen (2025)
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Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing (2025)
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Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025)
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Review of black cohosh-induced toxicity and adverse clinical effects (2025)
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Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025)
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Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities (2025)
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Isolation and Cryopreservation of Primary Macaque Hepatocytes (2024)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Application of HepaRG cells for genotoxicity assessment: a review (2024)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models (2023)
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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023)
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High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing (2023)
Collaboration Network
Top Collaborators
Xiaoqing Guo
National Center for Toxicological Research
13 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 13 shared publications
Nan Mei
United States Food and Drug Administration
8 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 8 shared publications
Robert H. Heflich
United States Food and Drug Administration
6 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Showing 5 of 6 shared publications
Xilin Li
National Center for Toxicological Research (US)
5 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing
Aisar Atrakchi
Center for Drug Evaluation and Research (US)
5 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Timothy J. McGovern
United States Food and Drug Administration (US)
5 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Hannah Xu
United States Food and Drug Administration (US)
5 shared publications
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Application of HepaRG cells for genotoxicity assessment: a review
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Karen L Davis Bruno
Center for Drug Evaluation and Research (US)
4 shared publications
- Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
- Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Pritpal Malhi
National Center for Toxicological Research
3 shared publications
In database
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Isolation and Cryopreservation of Primary Macaque Hepatocytes
- Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Xiaobo He
National Center for Toxicological Research
3 shared publications
In database
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Matthew Bryant
United States Food and Drug Administration
3 shared publications
In database
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Yuan Le
National Center for Toxicological Research
3 shared publications
In database
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Sangwon Byun
Korea Research Institute of Bioscience and Biotechnology (KR)
2 shared publications
- PKM2 Regulates HSP90-Mediated Stability of the IGF-1R Precursor Protein and Promotes Cancer Cell Survival during Hypoxia
- Abstract 5423: A focused shRNA library screening identifies MRPL38 as an oncogenic regulator of lung cancer via regulation of mitochondrial homeostasis
Kelly J. Davis
2 shared publications
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta)
- Isolation and Cryopreservation of Primary Macaque Hepatocytes
Tong Zhou
United States Food and Drug Administration (US)
2 shared publications
- High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
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