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Presence
Current · Arkansas
Last published
2021
Sources
OpenAlex · ORCID
Refreshed
2026-10-07
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Sharon D. Shelton
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Also affiliated: United States Food and Drug Administration (1996–2017); Dalian Medical University (2014); The University of Texas at Austin (2014)
14 h-index
30 pubs
745 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Sharon D. Shelton's research focuses on genotoxicity assessment and the evaluation of potential mutagens and carcinogens. Her work has investigated the mechanistic effects of compounds like black cohosh extract on human cells, examining their genotoxic potential. She employs various mutagenicity tests, often utilizing bacterial systems such as Escherichia coli and specific enzymes like hypoxanthine phosphoribosyltransferase to detect genetic mutations. Shelton's research also extends to the study of carcinogens and their impact on different biological models, including studies involving male and female rats. She has published 30 papers, accumulating 739 citations and maintaining an h-index of 14. Key collaborators include Volodymyr Tryndyak, Nan Mei, Xiaoqing Guo, and Xilin Li, all affiliated with the National Center for Toxicological Research.
Metrics
- h-index: 14
- Publications: 30
- Citations: 745
Selected Publications
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Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021)
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Dose and temporal evaluation of ethylene oxide‐induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations (2017)
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Evaluation of cII gene mutation in the brains of Big Blue mice exposed to acrylamide and glycidamide in drinking water (2016)
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Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks (2015)
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Acrylamide‐induced carcinogenicity in mouse lung involves mutagenicity: cII gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks (2015)
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Development and validation of a new transgenic hairless albino mouse as a mutational model for potential assessment of photocarcinogenicity (2015)
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Temporal Changes in K-ras Mutant Fraction in Lung Tissue of Big Blue B6C3F1 Mice Exposed to Ethylene Oxide (2013)
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In Vivo cII, gpt, and Spi− Gene Mutation Assays in Transgenic Mice and Rats (2013)
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Effects of acrylamide and glycidamide on the expression levels of hepatic mitochondria-related genes in transgenic Big Blue mice (2011)
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Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice (2010)
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Mutagenic toxicity of acrylamide and glycidamide in germ cells of mice (2009)
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Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks (2009)
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Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice (2008)
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The genetic toxicology of methylphenidate hydrochloride in non-human primates (2008)
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Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized Big Blue(R) transgenic rats (2006)
Collaboration Network
Top Collaborators
Mugimane G. Manjanatha
National Center for Toxicological Research
26 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green
- Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice
- Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene
- Acrylamide‐induced carcinogenicity in mouse lung involves mutagenicity: cII gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks
Showing 5 of 26 shared publications
Anane Aidoo
National Center for Toxicological Research (US)
6 shared publications
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
- Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized Big Blue(R) transgenic rats
Showing 5 of 6 shared publications
Lascelles E. Lyn‐Cook
National Center for Toxicological Research
6 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
- Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized Big Blue(R) transgenic rats
Showing 5 of 6 shared publications
Daniel A. Casciano
National Center for Toxicological Research (US)
6 shared publications
- Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Molecular analysis of lacI mutations in Rat2TM cells exposed to 7,12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
- A mutation in the p53 tumor suppressor gene of AHH-1 tk+− human lymphoblastoid cells
Showing 5 of 6 shared publications
Roberta A. Mittelstaedt
National Center for Toxicological Research
5 shared publications
In database
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Gene‐ and tissue‐specificity of mutation in Big Blue® rats treated with the hepatocarcinogen N‐hydroxy‐2‐acetylaminofluorene†
- In Vivo cII, gpt, and Spi− Gene Mutation Assays in Transgenic Mice and Rats
Robert H. Heflich
National Center for Toxicological Research
5 shared publications
In database
- Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
- Gene‐ and tissue‐specificity of mutation in Big Blue® rats treated with the hepatocarcinogen N‐hydroxy‐2‐acetylaminofluorene†
- In Vivo cII, gpt, and Spi− Gene Mutation Assays in Transgenic Mice and Rats
Daniel R. Doerge
National Center for Toxicological Research
5 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice
- Acrylamide‐induced carcinogenicity in mouse lung involves mutagenicity: cII gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
Nan Mei
National Center for Toxicological Research
5 shared publications
In database
- Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice
- Evaluation of cII gene mutation in the brains of Big Blue mice exposed to acrylamide and glycidamide in drinking water
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Endogenous estrogen status, but not genistein supplementation, modulates 7,12-dimethylbenz[a]anthracene-induced mutation in the livercII gene of transgenic big blue rats
- Mutagenic toxicity of acrylamide and glycidamide in germ cells of mice
Suzanne M. Morris
National Center for Toxicological Research (US)
4 shared publications
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- A mutation in the p53 tumor suppressor gene of AHH-1 tk+− human lymphoblastoid cells
- Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks
Joseph G. Shaddock
National Center for Toxicological Research
4 shared publications
In database
- Molecular analysis of lacI mutations in Rat2TM cells exposed to 7,12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks
Michelle E. Bishop
National Center for Toxicological Research
4 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- 17 ?-estradiol and not genistein modulateslacI mutant frequency and types of mutation induced in the heart of ovariectomized big blue rats treated with 7, 12-dimethylbenz[a]anthracene
- Endogenous estrogen status, but not genistein supplementation, modulates 7,12-dimethylbenz[a]anthracene-induced mutation in the livercII gene of transgenic big blue rats
Martha M. Moore
National Center for Toxicological Research (US)
4 shared publications
- Temporal Changes in K-ras Mutant Fraction in Lung Tissue of Big Blue B6C3F1 Mice Exposed to Ethylene Oxide
- Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks
- Dose and temporal evaluation of ethylene oxide‐induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations
- Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks
Vasily N. Dobrovolsky
National Center for Toxicological Research
3 shared publications
In database
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks
Donald R. Mattison
Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
3 shared publications
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks
L. Patrice McDaniel
National Center for Toxicological Research (US)
3 shared publications
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice
- Mutagenic toxicity of acrylamide and glycidamide in germ cells of mice
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