Biography and Research Information
OverviewAI-generated summary
Volodymyr Tryndyak's research investigates the molecular mechanisms underlying toxicity and disease, with a focus on epigenetic alterations and gene expression changes in response to environmental exposures and dietary factors. His work has explored the impact of specific diets, such as high-fat and high-sucrose, on the liver, examining associated DNA methylation and gene expression changes in genetically diverse mouse models. Tryndyak also studies the epigenetic effects of dietary components like methionine and investigates the genotoxicity of various compounds, including perfluorinated chemicals and herbal extracts, in human cells and animal models.
Further research by Tryndyak has examined the toxicokinetics of specific chemical metabolites in pregnant and non-pregnant rats and the potential mechanisms of apoptosis induced by inorganic arsenic in zebrafish. His work also includes analyzing the dynamics of SARS-CoV-2 genomes and identifying variants in wastewater, contributing to public health surveillance. With an h-index of 44 and over 6,600 citations from 158 publications, Tryndyak is recognized as a highly cited researcher. He has a history of collaboration with researchers at the National Center for Toxicological Research, including Igor P. Pogribny and Frederick A. Beland.
Metrics
- h-index: 44
- Publications: 158
- Citations: 6,646
Selected Publications
-
Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model (2025)
-
Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice (2025)
-
Wastewater dataset on the SARS-CoV-2 sublineages circulating in Central Arkansas, USA, post-COVID-19 pandemic (2025)
-
A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024)
-
Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification (2023)
-
Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound (2023)
-
Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish (2023)
-
Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin (2023)
-
Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice (2023)
-
Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas (2022)
-
Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice (2022)
-
Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet (2022)
-
Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets (2022)
-
Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021)
Collaboration Network
Top Collaborators
Igor P. Pogribny
National Center for Toxicological Research
31 shared publications
In database
- Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Showing 5 of 31 shared publications
Frederick A. Beland
National Center for Toxicological Research
27 shared publications
In database
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
- Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
Showing 5 of 27 shared publications
Aline de Conti
20 shared publications
- Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Table S1 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S3 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S6 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
Showing 5 of 20 shared publications
Kostiantyn Dreval
Simon Fraser University (CA)
19 shared publications
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
- Table S1 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S3 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S6 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Table S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
Showing 5 of 19 shared publications
Orish Ebere Orisakwe
18 shared publications
- Table S1 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S3 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S6 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Table S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
Showing 5 of 18 shared publications
Sharon A. Ross
18 shared publications
- Table S1 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S3 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S6 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Table S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Figure S2 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
Showing 5 of 18 shared publications
Rose Willett
National Center for Toxicological Research
8 shared publications
In database
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification
Showing 5 of 8 shared publications
Ivan Rusyn
Texas A&M University (US)
6 shared publications
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
Showing 5 of 6 shared publications
Mark Avigan
United States Food and Drug Administration (US)
5 shared publications
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
- Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice
Olga Kovalchuk
4 shared publications
- Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
Jody Filkowski
4 shared publications
- Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
James Meservy
4 shared publications
- Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
Yaroslav Ilnytskyy
4 shared publications
- Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
В Ф Чехун
4 shared publications
- Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Supplementary Table S1 from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Data from Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
Suresh K. Nagumalli
National Center for Toxicological Research
3 shared publications
In database
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Similar Researchers
Based on overlapping research topics
Frederick A. Beland
National Center for Toxicological Research
Epigenetics and DNA Methylation
Diet and metabolism studies
Carcinogens and Genotoxicity Assessment
Justin Treas
University of Arkansas for Medical Sciences
Epigenetics and DNA Methylation
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Igor Koturbash
University of Arkansas for Medical Sciences
Epigenetics and DNA Methylation
Diet and metabolism studies
Carcinogens and Genotoxicity Assessment
Mona I. Churchwell
National Center for Toxicological Research
Diet and metabolism studies
Carcinogens and Genotoxicity Assessment
Metabolomics and Mass Spectrometry Studies
Jack Hinson
University of Arkansas for Medical Sciences
Diet and metabolism studies
Carcinogens and Genotoxicity Assessment
Pharmacological Effects and Toxicity Studies
Shuk‐Mei Ho
University of Arkansas for Medical Sciences
Carcinogens and Genotoxicity Assessment
Metabolomics and Mass Spectrometry Studies
Disease Mechanisms Research