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Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-06
V
Vijayalakshmi Sridharan
High Impact
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Also affiliated: Medical University of South Carolina (2006–2009); University of Arkansas Medical Center (2018); Georgetown University Medical Center (2024); Moffitt Cancer Center (2012); MUSC Hollings Cancer Center (2007); Central Arkansas Veterans Healthcare System (2012); National Institute of Immunology (2004–2005); Georgetown Lombardi Comprehensive Cancer Center (2024); Charité - Universitätsmedizin Berlin (2012)
28 h-index
100 pubs
2,571 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Vijayalakshmi Sridharan's research investigates the physiological effects of radiation, particularly ionizing and space-type radiation, on biological systems. Her work has explored the impact of such radiation on the mouse gut microbiome and metabolome, as well as its effects on the heart and the retina. Sridharan's publications also address mechanisms of mitochondrial injury and activation, including the role of oxygen-sensing signal cascades and AKT3 kinase in response to stimuli like ischemia-reperfusion and VEGF.
Her research interests extend to molecular mechanisms in various biological contexts, including the enzymic activation and transfer of fatty acids in mycobacteria and the role of plasma membrane nucleolin as a receptor for anticancer aptamers. Sridharan has a significant publication record with 101 publications and over 2,500 citations, reflected in her h-index of 28. She has collaborated extensively with researchers at the University of Arkansas for Medical Sciences, including Marjan Boerma, Martin Hauer-Jensen, Benjamin J. Lieblong, and Ashley Nemec-Bakk.
Metrics
- h-index: 28
- Publications: 100
- Citations: 2,571
Selected Publications
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Changes in gut, microbiome, and cognition after doxorubicin, cyclophosphamide, and paclitaxel chemotherapy treatment (2026)
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Implications of cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy on hippocampal-dependent cognition and gut microbiome (2025)
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Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)
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Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming (2025)
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Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading (2024)
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Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma (2024)
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Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma (2024)
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A pooled analysis of nine studies in one institution to assess effects of whole heart irradiation in rat models (2023)
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TLR4—A Pertinent Player in Radiation-Induced Heart Disease? (2023)
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Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction (2023)
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Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model (2023)
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Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart (2023)
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Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart (2023)
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Low dose space radiation-induced effects on the mouse retina and blood-retinal barrier integrity (2022)
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Small animal models of localized heart irradiation (2022)
Collaboration Network
Top Collaborators
Marjan Boerma
University of Arkansas for Medical Sciences
53 shared publications
In database
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis
- Spaceflight induces oxidative damage to blood‐brain barrier integrity in a mouse model
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
Showing 5 of 53 shared publications
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
19 shared publications
In database
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Pharmacological Induction of Transforming Growth Factor-Beta1 in Rat Models Enhances Radiation Injury in the Intestine and the Heart
Showing 5 of 19 shared publications
Xiao Wen Mao
Loma Linda University (US)
14 shared publications
- Effects of ionizing radiation on the heart
- Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis
- Spaceflight induces oxidative damage to blood‐brain barrier integrity in a mouse model
- Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations
- Acute Effect of Low-Dose Space Radiation on Mouse Retina and Retinal Endothelial Cells
Showing 5 of 14 shared publications
Amrita K. Cheema
Georgetown University (US)
13 shared publications
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
Showing 5 of 13 shared publications
Gregory A. Nelson
Loma Linda University (US)
13 shared publications
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Acute Effect of Low-Dose Space Radiation on Mouse Retina and Retinal Endothelial Cells
- Combined Effects of Low-Dose Proton Radiation and Simulated Microgravity on the Mouse Retina and the Hematopoietic System
Showing 5 of 13 shared publications
Igor Koturbash
University of Arkansas for Medical Sciences
12 shared publications
In database
- Effects of ionizing radiation on the heart
- Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation
Showing 5 of 12 shared publications
Maohua Cao
10 shared publications
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart
- Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart
- Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model
- Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats
Showing 5 of 10 shared publications
Eduardo G. Moros
Moffitt Cancer Center (US)
9 shared publications
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- Cardiac Inflammation after Local Irradiation Is Influenced by the Kallikrein-Kinin System
- Effects of Late Administration of Pentoxifylline and Tocotrienols in an Image-Guided Rat Model of Localized Heart Irradiation
- A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure
- Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart
Showing 5 of 9 shared publications
John W. Seawright
McLennan Community College (US)
9 shared publications
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart
- Late effects of 1H irradiation on hippocampal physiology
- Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model
- Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O)
Showing 5 of 9 shared publications
Preeti Singh
Rite Aid (United States) (US)
9 shared publications
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart
- Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model
- Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O)
- Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats
Showing 5 of 9 shared publications
Reid D. Landes
University of Arkansas for Medical Sciences
9 shared publications
In database
- Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice
- Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O)
- Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
- Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice
Showing 5 of 9 shared publications
Yaoxiang Li
Georgetown University (US)
9 shared publications
- Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity
- Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
- Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction
- Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model
Showing 5 of 9 shared publications
Sunil Sharma
University of Arkansas for Medical Sciences (US)
8 shared publications
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- Cardiac Inflammation after Local Irradiation Is Influenced by the Kallikrein-Kinin System
- Effects of Late Administration of Pentoxifylline and Tocotrienols in an Image-Guided Rat Model of Localized Heart Irradiation
- A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure
- Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart
Showing 5 of 8 shared publications
Antiño R. Allen
University of Arkansas Medical Center
8 shared publications
In database
- Long-Term Changes in Cognition and Physiology after Low-Dose 16O Irradiation
- Late Effects of 1H + 16O on Short-Term and Object Memory, Hippocampal Dendritic Morphology and Mutagenesis
- Late effects of 1H irradiation on hippocampal physiology
- Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart
- Low dose space radiation-induced effects on the mouse retina and blood-retinal barrier integrity
Showing 5 of 8 shared publications
Kimberly J. Krager
University of Arkansas for Medical Sciences
7 shared publications
In database
- Radiation-Induced Alterations in Mitochondria of the Rat Heart
- TLR4—A Pertinent Player in Radiation-Induced Heart Disease?
- A Tocotrienol-Enriched Formulation Protects against Radiation-Induced Changes in Cardiac Mitochondria without Modifying Late Cardiac Function or Structure
- Characterization of Transgenic Gfrp Knock-In Mice: Implications for Tetrahydrobiopterin in Modulation of Normal Tissue Radiation Responses
- Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin
Showing 5 of 7 shared publications
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