Vijayalakshmi Sridharan

High Impact

Researcher

UAMS

Last publication 2026 Last refreshed 2026-05-16

faculty

27 h-index 101 pubs 2,495 cited

Research Areas

Links

ORCID

OverviewAI-generated summary

Vijayalakshmi Sridharan's research focuses on the physiological and structural effects of radiation on the heart and other organs. Her work investigates radiation-induced cardiac dysfunction, including its underlying mechanisms and potential preventative strategies. Sridharan has examined the effects of different types of radiation, such as protons and simulated galactic cosmic radiation, on cardiac function and structure in animal models, primarily mice and rats.

Her publications explore various factors influencing radiation's impact, including sex-dependent effects and the role of specific genes like TLR4 and M2. Sridharan also investigates potential therapeutic interventions, such as the use of dantrolene to prevent doxorubicin-induced lymphostasis and the application of metabolomics for predicting radiation-induced cardiac dysfunction. She has collaborated with several researchers at the University of Arkansas for Medical Sciences, including Marjan Boerma, Martin Hauer-Jensen, Benjamin J. Lieblong, and Reid D. Landes, on numerous shared publications.

Sridharan's scholarship metrics include an h-index of 27, with over 101 publications and 2,470 citations. She is recognized as a highly cited researcher, indicating a significant impact in her field. Her recent activity and publication record demonstrate ongoing engagement with these research areas.

Metrics

h-index: 27
Publications: 101
Citations: 2,495

Selected Publications

Changes in gut, microbiome, and cognition after doxorubicin, cyclophosphamide, and paclitaxel chemotherapy treatment (2026)

DOI OpenAlex
Implications of cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy on hippocampal-dependent cognition and gut microbiome (2025)

1 citation DOI OpenAlex
Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025)

DOI OpenAlex
Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming (2025)

1 citation DOI OpenAlex
Sex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading (2024)

2 citations DOI OpenAlex
Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma (2024)

1 citation DOI OpenAlex
Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma (2024)

DOI OpenAlex
A pooled analysis of nine studies in one institution to assess effects of whole heart irradiation in rat models (2023)

DOI OpenAlex
TLR4—A Pertinent Player in Radiation-Induced Heart Disease? (2023)

36 citations DOI OpenAlex
Urinary Metabolomics for the Prediction of Radiation-Induced Cardiac Dysfunction (2023)

8 citations DOI OpenAlex
Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model (2023)

5 citations DOI OpenAlex
Effects of Simulated 5-Ion Galactic Cosmic Radiation on Function and Structure of the Mouse Heart (2023)

8 citations DOI OpenAlex
Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart (2023)

3 citations DOI OpenAlex
Low dose space radiation-induced effects on the mouse retina and blood-retinal barrier integrity (2022)

6 citations DOI OpenAlex
Small animal models of localized heart irradiation (2022)

5 citations DOI OpenAlex