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Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
Q
Qiangen Wu
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
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Also affiliated: United States Food and Drug Administration (2010–2025); Fudan University (2005–2009); Indiana University Bloomington (2014–2024); Indiana University (2014–2024)
22 h-index
60 pubs
1,164 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Qiangen Wu's research focuses on investigating the toxicity of various chemical compounds and environmental exposures using in vitro models. Wu has published studies evaluating the effects of substances such as cannabidiol, formaldehyde, glutaraldehyde, and ortho-phthalaldehyde on human cell lines and tissue models, including HepG2 cells, Sertoli cells, Leydig cells, and human airway epithelial tissues. These investigations often integrate methods like transcriptome analysis to understand the underlying mechanisms of toxicity.
Wu's work includes assessing drug metabolism and liver toxicity, as well as the sub-acute and chronic effects of inhaled substances. Collaborations with researchers at the National Center for Toxicological Research, including Matthew Bryant, Xuefei Cao, Si Chen, and Frederick A. Beland, have contributed to a body of work on toxicological assessment. Wu leads a research group dedicated to these toxicological studies and has a notable publication record with an h-index of 21 and over 1,100 citations.
Metrics
- h-index: 22
- Publications: 60
- Citations: 1,164
Selected Publications
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Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025)
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NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite (2025)
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Retraction notice to “On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression” [Neurotoxicology and Teratology 33 (2011) 288–296] (2025)
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7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells (2025)
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Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78] (2024)
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Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024)
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Investigation of cannabidiol-induced cytotoxicity in human hepatic cells (2024)
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Metabolism and liver toxicity of cannabidiol (2024)
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Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells (2024)
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The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024)
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Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024)
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Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model (2022)
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Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model (2022)
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In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells (2021)
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Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model (2021)
Collaboration Network
Top Collaborators
Matthew Bryant
National Center for Toxicological Research
17 shared publications
In database
- Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria
- The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
- Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes
Showing 5 of 17 shared publications
Lei Guo
National Center for Toxicological Research
14 shared publications
In database
- The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
Showing 5 of 14 shared publications
Xuefei Cao
National Center for Toxicological Research
10 shared publications
In database
- Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model
- Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model
Showing 5 of 10 shared publications
Frederick A. Beland
8 shared publications
In database
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Differential effects of triclosan on the activation of mouse and human peroxisome proliferator-activated receptor alpha
- XPC is essential for nucleotide excision repair of zidovudine-induced DNA damage in human hepatoma cells
- Role of DNA Repair Pathways in Response to Zidovudine-induced DNA Damage in Immortalized Human Liver THLE2 Cells.
- Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine
Showing 5 of 8 shared publications
Jia‐Long Fang
8 shared publications
In database
- Cytotoxicity and inhibitory effects of low-concentration triclosan on adipogenic differentiation of human mesenchymal stem cells
- Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1
- Differential effects of triclosan on the activation of mouse and human peroxisome proliferator-activated receptor alpha
- XPC is essential for nucleotide excision repair of zidovudine-induced DNA damage in human hepatoma cells
- Role of DNA Repair Pathways in Response to Zidovudine-induced DNA Damage in Immortalized Human Liver THLE2 Cells.
Showing 5 of 8 shared publications
Levan Muskhelishvili
8 shared publications
- Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model
- Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model
Showing 5 of 8 shared publications
Nan Mei
National Center for Toxicological Research
7 shared publications
In database
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing
- Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells
Showing 5 of 7 shared publications
Kelly J. Davis
7 shared publications
In database
- Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model
- Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model
Showing 5 of 7 shared publications
Si Chen
National Center for Toxicological Research
7 shared publications
In database
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
Showing 5 of 7 shared publications
Hans Rosenfeldt
Japan Tobacco (United States) (US)
6 shared publications
- Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- In vitro dosimetry analyses for acrolein exposure in normal human lung epithelial cells and human lung cancer cells
- Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
Showing 5 of 6 shared publications
Baitang Ning
National Center for Toxicological Research
5 shared publications
In database
- Cytotoxicity and inhibitory effects of low-concentration triclosan on adipogenic differentiation of human mesenchymal stem cells
- The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone
Xiaoqing Guo
National Center for Toxicological Research
5 shared publications
In database
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing
- Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells
- Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines
- NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite
Xilin Li
National Center for Toxicological Research
5 shared publications
In database
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
Yuxi Li
National Center for Toxicological Research
5 shared publications
In database
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
- 7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells
Elvis Cuevas
Instituto Nacional de Neurología y Neurocirugía (MX)
4 shared publications
- RETRACTED: On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression
- RETRACTED: On the early toxic effect of quinolinic acid: Involvement of RAGE
- Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78]
- Retraction notice to “On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression” [Neurotoxicology and Teratology 33 (2011) 288–296]
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