E. Kim Fifer
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Also affiliated: West Virginia University (1986–1995); United States Food and Drug Administration (1985); University of Massachusetts Amherst (2012); University of Florida (2013); University of Mississippi (1980–1985)
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
E. Kim Fifer's research has focused on the metabolic activation and genotoxicity of polycyclic aromatic hydrocarbons, particularly nitropyrenes. This work has involved investigating the synthesis and mutagenicity of potential metabolic intermediates, such as 1-nitro-6-nitrosopyrene and 1-nitro-8-nitrosopyrene. Studies have examined the in vitro and in vivo DNA binding of 1-nitropyrene and 1,6-dinitropyrene, and the effects of nitroreductase induction on these processes.
Additional research interests have included the pharmacokinetics of botanical dietary supplements and their potential for drug interactions. Fifer has also investigated mechanisms of acetaminophen-induced hepatotoxicity in mice, specifically the inhibition and nitration of mitochondrial manganese superoxide dismutase. Other work has explored the quantitative measurement of metabolites of synthetic cannabinoids in human urine and the efficacy of quaternary ammonium compounds in reducing Salmonella typhimurium attachment to poultry tissues.
Metrics
- h-index: 20
- Publications: 48
- Citations: 1,165
Selected Publications
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Clinically Relevant Herb-Micronutrient Interactions: When Botanicals, Minerals, and Vitamins Collide (2018)
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Crystal structure of 4,4′-bis[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl (2017)
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Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures (2015)
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Comparison crystal structure conformations of two structurally related biphenyl analogues: 4,4′-bis[3-(pyrrolidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl and 4,4′-bis{3-[(S)-2-methylpyrrolidin-1-yl]prop-1-yn-1-yl}-1,1′-biphenyl (2015)
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Comparison of the crystal structures of 4,4′-bis[3-(4-methylpiperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl and 4,4′-bis[3-(2,2,6,6-tetramethylpiperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl (2015)
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Hydrastine Pharmacokinetics and Metabolism after a Single Oral Dose of Goldenseal (Hydrastis canadensis) to Humans (2015)
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Multiple Modes of α7 nAChR Noncompetitive Antagonism of Control Agonist-Evoked and Allosterically Enhanced Currents (2013)
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Solid-Phase Extraction and Quantitative Measurement of Omega and Omega-1 Metabolites of JWH-018 and JWH-073 in Human Urine (2011)
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Drug–Organic Electrolyte Complexes as Controlled Release Systems (2008)
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T Cell Tolerance Induced by Histone Deacetylase Inhibitor is Mediated by P21cip1 (2005)
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Structure–activity relationship between carboxylic acids and T cell cycle blockade (2005)
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Macrophage production of inflammatory mediators is potently inhibited by a butyric acid derivative demonstrated to inactivate antigen-stimulated T cells (2004)
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Butyric Acid Derivative Induces Allospecific T Cell Anergy and Prevents Graft-Versus-Host Disease (2003)
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High-performance liquid chromatography determination of residue levels on chicken carcasses treated with cetylpyridinium chloride (1999)
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Quaternary Ammonium Compounds Inhibit and Reduce the Attachment of Viable Salmonella typhimurium to Poultry Tissues (1995)
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