Florence McLellen Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

National Center for Toxicological Research

unknown

3 h-index 4 pubs 73 cited

Research Areas

Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment Bone health and treatments Metabolism and Genetic Disorders Analytical Chemistry and Chromatography

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OverviewAI-generated summary

Florence McLellen's research investigates the pharmacological effects and potential toxicity of various substances, primarily utilizing rodent models. Her recent work includes a pharmacokinetic analysis of nicotine and its metabolites in Sprague-Dawley rats, examining different administration routes. She has also studied the molecular mechanisms of drug-induced cellular changes, such as the detection of lorcaserin-induced clonal expansion of specific gene mutations in rat mammary tissue using CarcSeq. Additionally, McLellen's research has explored the impact of co-administered compounds on bone health in an ovariectomized rat model, specifically investigating the effects of black cohosh extract and risedronate.

Metrics

  • h-index: 3
  • Publications: 4
  • Citations: 73

Selected Publications

  • Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024) DOI
  • CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue (2024) DOI
  • The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024) DOI

Collaborators

Researchers in the database who share publications

Matthew Bryant National Center for Toxicological Research 3 shared publications Qiangen Wu National Center for Toxicological Research 2 shared publications Elysia A. Masters National Center for Toxicological Research 1 shared publication K. Barry Delclos National Center for Toxicological Research 1 shared publication Luísa Camacho National Center for Toxicological Research 1 shared publication Amy L. Inselman National Center for Toxicological Research 1 shared publication Richard D. Beger National Center for Toxicological Research 1 shared publication Noriko Nakamura National Center for Toxicological Research 1 shared publication

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