F
Florence McLellen Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Researcher
unknown
3 h-index
4 pubs
76 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Florence McLellen's research focuses on the toxicological effects of substances and their metabolic pathways, primarily utilizing rat models. Her recent work investigates the pharmacokinetics of nicotine and its metabolites, including cotinine and trans-3′-hydroxycotinine, following various administration routes in Sprague-Dawley rats. McLellen also studies the detection of drug-induced genetic mutations, specifically examining lorcaserin-induced clonal expansion of Pik3ca mutants in rat mammary tissue. Additionally, her research explores the impact of co-administered compounds on bone health, as seen in studies involving black cohosh extract and risedronate in an ovariectomized rat model. McLellen has published four total publications with 74 citations and an h-index of 3. She has collaborated with Matthew Bryant, Qiangen Wu, Elysia A. Masters, and K. Barry Delclos, all from the National Center for Toxicological Research.
Metrics
- h-index: 3
- Publications: 4
- Citations: 76
Selected Publications
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Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024)
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CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue (2024)
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The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024)
Collaboration Network
Top Collaborators
Matthew Bryant
United States Food and Drug Administration
3 shared publications
In database
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Qiangen Wu
United States Food and Drug Administration
2 shared publications
In database
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Amy L. Inselman
Center for Systems Biology
1 shared publication
In database
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Elysia A. Masters
United States Food and Drug Administration
1 shared publication
In database
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Jalina N. Moore
United States Food and Drug Administration
1 shared publication
In database
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Rajiv Agarwal
Center for Drug Evaluation and Research (US)
1 shared publication
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Audrey Gassman
Center for Drug Evaluation and Research (US)
1 shared publication
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Gemma A.J. Kuijpers
Center for Drug Evaluation and Research (US)
1 shared publication
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Richard D. Beger
National Center for Toxicological Research
1 shared publication
In database
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
K. Barry Delclos
National Center for Toxicological Research
1 shared publication
In database
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Sybil Swift
Center for Food Safety and Applied Nutrition (US)
1 shared publication
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Luísa Camacho
National Center for Toxicological Research
1 shared publication
In database
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Michelle M. Vanlandingham
National Center for Toxicological Research
1 shared publication
In database
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Daniel T. Sloper
Center for Systems Biology
1 shared publication
In database
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Noriko Nakamura
National Center for Toxicological Research
1 shared publication
In database
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
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