Florence McLellen
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Researcher
Also affiliated: United States Food and Drug Administration (2019–2024)
Unknown Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Florence McLellen's research focuses on the toxicological effects of substances and their metabolic pathways, primarily utilizing rat models. Her recent work investigates the pharmacokinetics of nicotine and its metabolites, including cotinine and trans-3′-hydroxycotinine, following various administration routes in Sprague-Dawley rats. McLellen also studies the detection of drug-induced genetic mutations, specifically examining lorcaserin-induced clonal expansion of Pik3ca mutants in rat mammary tissue. Additionally, her research explores the impact of co-administered compounds on bone health, as seen in studies involving black cohosh extract and risedronate in an ovariectomized rat model. McLellen has published four total publications with 74 citations and an h-index of 3. She has collaborated with Matthew Bryant, Qiangen Wu, Elysia A. Masters, and K. Barry Delclos, all from the National Center for Toxicological Research.
Metrics
- h-index: 3
- Publications: 4
- Citations: 76
Selected Publications
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Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024)
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CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue (2024)
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The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024)
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A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results (2019)
Collaboration Network
Top Collaborators
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
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