Neriman Gökden
Professor
Also affiliated: Barnes-Jewish Hospital (2000–2003); Duke University (2000); Dokuz Eylül University (1995–1997); Washington University in St. Louis (2000–2003); University of Arkansas Medical Center (2015); University of Arkansas System (2016); Ospedale Antonio Cardarelli (2000); Central Arkansas Veterans Healthcare System (2004–2012); Duke Medical Center (2000); Washington University Medical Center (2003); United States and Canadian Academy of Pathology (2003); Vanderbilt University Medical Center (2005)
Pathology, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Neriman Gökden's research focuses on the mechanisms of acute kidney injury (AKI) and renal cell carcinoma. Her work has investigated the role of oxidative stress and reactive nitrogen species in the peritubular capillary microenvironment, contributing to the understanding of sepsis-induced renal microcirculatory failure and tubular injury in animal models.
Her publications include studies on the protective effects of resveratrol in a mouse model of sepsis-induced AKI, as well as research exploring the dysfunction of peritubular capillaries following lipopolysaccharide administration. Gökden has also examined the anti-inflammatory effects of fibrates in protecting against cisplatin-induced AKI. Additionally, her work has addressed specific subtypes of renal cell carcinoma, including those with rhabdoid features and eosinophilic solid and cystic variants, and has explored immunohistochemical distinctions for adrenal cortical lesions versus metastatic renal cell carcinoma.
Gökden leads a research group and has a publication record with an h-index of 29, with nearly 3,000 citations across 98 publications. She has a history of collaboration with researchers from the University of Arkansas for Medical Sciences, including Ahmet Murat Aydın, Amod Sharma, Timothy Langford, and Nirmala Parajuli, with whom she shares multiple publications.
Metrics
- h-index: 30
- Publications: 113
- Citations: 3,042
Positions
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Professor publications 2026University of Arkansas at Fayetteville Pathology, College of Medicine Institutional directory
Selected Publications
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10 Outcomes of Patients with Renal Cell Carcinoma Achieving Pathologic Complete or Major Response After Consolidative Nephrectomy Following Immune Checkpoint Inhibitor Therapy (2026)
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Testicular Plasmacytoma: A 25-Year Experience from a High-Volume Tertiary Center and Comparative Review of the Literature (2026)
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Effect of complement 3/5 knockout on renal proteomics landscape after ischemia and reperfusion injury in rats (2026)
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Impaired Renal Mitochondria and Bioenergetics During Obesity-Associated NAFLD (2026)
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Heat shock protein 72 is a druggable target during cold storage to improve graft outcome after kidney transplantation (2026)
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Novel interactions between the C5 ‐ C5aR 1 Axis and IF 1: Implications for kidney mitochondrial physiology and ischemia–reperfusion injury (2026)
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Impact of intraoperative intravenous heparin bolus on clinical outcomes during radical nephrectomy and IVC tumor thrombectomy in renal cell carcinoma with level I–IV IVC thrombus: A multi-institutional study (2026)
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Influence of Hypothermic Machine Perfusion on Markers of Oxidative Stress and Early Tubular Injury in Rat Donor Kidneys Before Transplantation (2026)
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Pathologic findings and clinical outcomes after immune checkpoint blockade in renal cell carcinoma patients undergoing deferred consolidative nephrectomy. (2026)
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Illuminating Blurry Vision: Visualization of Corneal Protein Deposition With Immunofluorescence in Two Illustrative Case Reports (2026)
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Metformin Attenuates Oxidative Stress and Inflammatory Responses in Obesity-Associated Nonalcoholic Fatty Liver Disease (NAFLD) (2025)
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Complement 5's Role in Mitochondria During Kidney Ischemia-Reperfusion Injury in Rats (2025)
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Compared with Static Cold Storage, Hypothermic Machine Perfusion Mitigates Oxidative Stress and Tubular Injury in Rat Kidneys (2025)
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Persistent BK Viremia Leads to BK Virus Nephropathy-Associated Graft Failure in a Simultaneous Liver-Kidney (SLK) Transplant Recipient on Ustekinumab (2025)
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Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat (2025)
Research Interests
I have had many collaborations with researchers in other departments, especially researchers in the Nephrology and Pharmacology/Toxicology divisions at UAMS and other institutions at both nationally and internationally. In such cases, I contributed to the funded basic research by providing diagnostic evaluation and clinical skills, providing guidance for histology, immunohistochemistry and electron microscopy use in research projects by taking full responsibility for ensuring rigorous quality control and quality assurance on all samples processed by the histology core laboratory. The majority of my research relates to genitourinary and renal pathology. - I worked on kidney and prostate cancer in collaboration with Dr. Graham Greene and Dr. Rabi Madi in Urology Department at UAMS, and Dr. Jesse McKenney at Stanford University, CA and Dr. Kiril Trpkov at University of Calgary, Canada. I have been awarded one of our departmental research grants for one of my own projects. - In renal pathology, I work on myeloma-related kidney diseases because of the large number of kidney biopsies coming from myeloma patients at the Myeloma Institute for Research and Therapy. My completed projects as PI were in collaboration with Dr. Bart Barlogie at UAMS, Dr. Helen Liapis at Washington University in Saint Louis, MO, and Dr. Patrick Walker at Nephropath Laboratory in Little Rock, AR. They included exploring morphologic heterogeneity of light chain deposition disease and cast nephropathy in a large series of cases. Our results have been published in prestigious, high impact journals. - In collaboration with the program project grant in our nephrology division which was funded by NIH and VA grants, work on kidney lipoprotein lipase, the role of renal tubule triglyceride accumulation in cisplatin-mediated acute renal failure, and the renal survival pathway in ischemia/reperfusion injury has been completed. Our results were published in several prestigious journals. - I have a long standing collaboration with Dr. Phillip Mayeux in the Pharmacology/Toxicology Department. Our completed projects included looking into hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury, the effects of resveratrol for improving renal microcirculation, protecting the tubular epithelium, and prolonging survival in a mouse model of sepsis-induced acute kidney injury. We also looked into the protective effects of Actinonin in the renal microcirculation during sepsis. Our collaborations were fruitful and several articles were published, one of which made the cover of the journal Kidney International.
Collaboration Network
Top Collaborators
- Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC)
- Immunohistochemical Distinction of Primary Adrenal Cortical Lesions From Metastatic Clear Cell Renal Cell Carcinoma
- Plasmacytoid Carcinoma of the Bladder: A Urothelial Carcinoma Variant With a Predilection for Intraperitoneal Spread
- The Utility of PAX-2 in Distinguishing Metastatic Clear Cell Renal Cell Carcinoma From its Morphologic Mimics
- Invasive Urothelial Carcinoma With Chordoid Features
Showing 5 of 11 shared publications
- Cold Storage Followed by Transplantation Induces Immunoproteasome in Rat Kidney Allografts: Inhibition of Immunoproteasome Does Not Improve Function
- Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat
- Obesity-Associated NAFLD Coexists with a Chronic Inflammatory Kidney Condition That Is Partially Mitigated by Short-Term Oral Metformin
- Novel interactions between the C5 ‐ C5aR 1 Axis and IF 1: Implications for kidney mitochondrial physiology and ischemia–reperfusion injury
- Unrecognized Effects of Metformin to Reduce Proteasomal Stress and Macrophage Infiltration in Kidneys of Obese Rats with NAFLD (Abstract ID: 166383)
Showing 5 of 11 shared publications
- Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
- Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney Injury
- Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice
- Evidence for the Role of Reactive Nitrogen Species in Polymicrobial Sepsis-Induced Renal Peritubular Capillary Dysfunction and Tubular Injury
- Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury
Showing 5 of 9 shared publications
- The Utility of PAX-2 in Distinguishing Metastatic Clear Cell Renal Cell Carcinoma From its Morphologic Mimics
- The Utility of Pax-2 and Renal Cell Carcinoma Marker Immunohistochemistry in Distinguishing Papillary Renal Cell Carcinoma From Nonrenal Cell Neoplasms With Papillary Features
- Diagnostic Utility of Renal Cell Carcinoma Marker in Cytopathology
- The utility of Pax‐2 as an immunohistochemical marker for renal cell carcinoma in cytopathology
- Expression of CD138 (Syndecan-1) in Renal Cell Carcinoma is Reduced With Increasing Nuclear Grade
Showing 5 of 9 shared publications
- External Validation of an Artificial Intelligence Algorithm Using Biparametric MRI and Its Simulated Integration with Conventional PI-RADS for Prostate Cancer Detection
- Stem Cell Origin of Cancer: Implications of Oncogenesis Recapitulating Embryogenesis in Cancer Care
- Stem Cell Origin of Cancer: Clinical Implications for Cancer Immunity and Immunotherapy
- Giant left pheochromocytoma with vascular anomalies and pelvic horseshoe kidney: a case report
- Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer
Showing 5 of 9 shared publications
- Cold Storage Followed by Transplantation Induces Immunoproteasome in Rat Kidney Allografts: Inhibition of Immunoproteasome Does Not Improve Function
- Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat
- Novel interactions between the C5 ‐ C5aR 1 Axis and IF 1: Implications for kidney mitochondrial physiology and ischemia–reperfusion injury
- Compared with Static Cold Storage, Hypothermic Machine Perfusion Mitigates Oxidative Stress and Tubular Injury in Rat Kidneys
- Complement 5's Role in Mitochondria During Kidney Ischemia-Reperfusion Injury in Rats
Showing 5 of 8 shared publications
- Expression of CD138 (Syndecan-1) in Renal Cell Carcinoma is Reduced With Increasing Nuclear Grade
- Metastatic renal cell carcinoma to prostate
- Should hilar lymph nodes be expected in radical nephrectomy specimens?
- Granular cell tumour of the ureter: first case reported
- Cyclooxygenase-2 expression in renal cell neoplasms
Showing 5 of 6 shared publications
- Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
- Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney Injury
- Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice
- Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury
- Rolipram Improves Renal Perfusion and Function during Sepsis in the Mouse
Showing 5 of 6 shared publications
- Invasive Urothelial Carcinoma With Chordoid Features
- The Utility of Pax-2 and Renal Cell Carcinoma Marker Immunohistochemistry in Distinguishing Papillary Renal Cell Carcinoma From Nonrenal Cell Neoplasms With Papillary Features
- Metastatic melanoma with dedifferentiation and extensive rhabdomyosarcomatous heterologous component
- Pseudoangiosarcomatous Urothelial Carcinoma of the Urinary Bladder
- Should hilar lymph nodes be expected in radical nephrectomy specimens?
Showing 5 of 6 shared publications
- Obesity-Associated NAFLD Coexists with a Chronic Inflammatory Kidney Condition That Is Partially Mitigated by Short-Term Oral Metformin
- Unrecognized Effects of Metformin to Reduce Proteasomal Stress and Macrophage Infiltration in Kidneys of Obese Rats with NAFLD (Abstract ID: 166383)
- Compared with Static Cold Storage, Hypothermic Machine Perfusion Mitigates Oxidative Stress and Tubular Injury in Rat Kidneys
- Heat shock protein 72 is a druggable target during cold storage to improve graft outcome after kidney transplantation
- Impaired Renal Mitochondria and Bioenergetics During Obesity-Associated NAFLD
Showing 5 of 6 shared publications
- Immunohistochemical Distinction of Primary Adrenal Cortical Lesions From Metastatic Clear Cell Renal Cell Carcinoma
- Plasmacytoid Carcinoma of the Bladder: A Urothelial Carcinoma Variant With a Predilection for Intraperitoneal Spread
- Invasive Urothelial Carcinoma With Chordoid Features
- The distribution of PAX-2 immunoreactivity in the prostate gland, seminal vesicle, and ejaculatory duct: comparison with prostatic adenocarcinoma and discussion of prostatic zonal embryogenesis
- Tuberous sclerosis complex: Hamartin and tuberin expression in renal cysts and its discordant expression in renal neoplasms
- Stem Cell Origin of Cancer: Implications of Oncogenesis Recapitulating Embryogenesis in Cancer Care
- Stem Cell Theory of Cancer: Clinical Implications for Cellular Metabolism and Anti-Cancer Metabolomics
- Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer
- Stem Cell Theory of Cancer: Clinical Implications of Epigenomic versus Genomic Biomarkers in Cancer Care
- Identification of a panel of microRNA biomarkers for the management of patients with refractory germ cell tumor of the testis.
- Stem Cell Origin of Cancer: Implications of Oncogenesis Recapitulating Embryogenesis in Cancer Care
- Stem Cell Theory of Cancer: Clinical Implications for Cellular Metabolism and Anti-Cancer Metabolomics
- Stem Cell Origin of Cancer: Clinical Implications for Cancer Immunity and Immunotherapy
- Stem Cell Theory of Cancer: Clinical Implications of Epigenomic versus Genomic Biomarkers in Cancer Care
- Identification of a panel of microRNA biomarkers for the management of patients with refractory germ cell tumor of the testis.
- Clinical characteristics and prognostic factors in multiple myeloma patients with light chain deposition disease
- Morphologic Heterogeneity of Renal Light-Chain Deposition Disease
- Morphologic Manifestations of Combined Light-chain Deposition Disease and Light-chain Cast Nephropathy
- An unusual clinical course of cardiac Ig deposition disease
- Clinical characteristics and prognostic factors in multiple myeloma patients with light chain deposition disease
- Granulomatosis with polyangiitis and renal cell cancer: A sinister association - case report and review of literature
- Membranous Nephropathy Over the Counter? NELL Yes!
- Membranous Nephropathy- over the counter? NELL yes!
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