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Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
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Beverly R. Word
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Also affiliated: United States Food and Drug Administration (2016–2022); Missouri Department of Agriculture (2018); Western University of Health Sciences (2008)
19 h-index
63 pubs
930 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Beverly Word's research focuses on the molecular mechanisms underlying cancer development and the pharmacological effects of potential therapeutic agents. Her work investigates how environmental factors, such as nanoparticles and chemical exposures, can alter gene expression and epigenetic modifications, including DNA methylation and histone modifications, in human cell lines. She has explored the anti-cancer effects of histone deacetylase (HDAC) inhibitors, specifically vorinostat, on pancreatic and triple-negative breast cancer models, including those cultured in three-dimensional environments and organoids. Her research has also identified specific gene expression profiles associated with African American pancreatic cancer tumors. Word holds an h-index of 19 with 63 total publications and 907 citations. She has collaborated extensively with researchers at the National Center for Toxicological Research, including Beverly Lyn‐Cook, George Hammons, Fatemeh Nouri Emamzaden, and Marta Pogribna.
Metrics
- h-index: 19
- Publications: 63
- Citations: 930
Selected Publications
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Exposure to a Titanium Dioxide Product Alters MicroRNA Expression in Human Cells (2026)
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Abstract C054: Pharmacogenomics evaluation of histone deacetylase inhibitors on the treatment of triple-negative breast cancer subtypes (2025)
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Exposure to a Titanium Dioxide Product Alters DNA Methylation in Human Cells (2024)
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Abstract 4253: High expression of specific gene profiles in organoids from African American pancreatic cancer tumors (2024)
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Abstract 6251: High expression level of GSK3β in basal triple negative breast cancer: Effects of the HDAC inhibitor, vorinostat (2023)
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Effect of titanium dioxide nanoparticles on histone modifications and histone modifying enzymes expression in human cell lines (2022)
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Abstract 1631: Anti-cancer effects of vorinostat on 3D cultured pancreatic cancer cells (2022)
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Abstract 995: Alpelisib and vorinostat modulate critical genes in basal-2 triple negative breast cancer cells and inhibit cell growth and invasion (2021)
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Abstract B125: Molecular profiling basal 2 subtypes of triple-negative breast cancer cells and their response to histone deacetylase inhibitor (2020)
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Abstract PO-218: Molecular profiling of basal 2 subtypes of triple negative breast cancer cells and their response to a histone deacetylase inhibitor (2020)
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Abstract C109: Modulation of HDAC activity in subtypes of triple-negative breast cancer: Effects of vorinostat on HDAC 7 expression and cancer stem cells progression (2020)
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Modulation of Estrogen α and Progesterone Receptors in Triple Negative Breast Cancer Cell Lines: The Effects of Vorinostat and Indole-3-Carbinol In Vitro (2020)
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Effect of titanium dioxide nanoparticles on DNA methylation in multiple human cell lines (2020)
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Abstract 5196: Vorinostat exhibits anticancer effects through modulation of nuclear receptors and tumor suppressor genes in sub-types of triple negative breast cancer cells (2019)
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Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: Identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI (2018)
Collaboration Network
Top Collaborators
Beverly Lyn‐Cook
National Center for Toxicological Research
51 shared publications
In database
- Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: Ethnic differences and potential new targets for therapeutic drugs
- Effect of titanium dioxide nanoparticles on DNA methylation in multiple human cell lines
- Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: Identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI
- Expression of drug transporters in human kidney: impact of sex, age, and ethnicity
- Age and gender affect DNMT3a and DNMT3b expression in human liver
Showing 5 of 51 shared publications
George Hammons
National Center for Toxicological Research
34 shared publications
In database
- Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: Ethnic differences and potential new targets for therapeutic drugs
- Effect of titanium dioxide nanoparticles on DNA methylation in multiple human cell lines
- Expression of drug transporters in human kidney: impact of sex, age, and ethnicity
- Age and gender affect DNMT3a and DNMT3b expression in human liver
- Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreas
Showing 5 of 34 shared publications
Stancy Joseph
National Center for Toxicological Research (US)
8 shared publications
- Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: Identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI
- Expression of drug transporters in human kidney: impact of sex, age, and ethnicity
- Abstract 4436: Metformin upregulates hENT1 expression and enhances gemcitabine efficacy in pancreatic cancer cells
- Abstract 4428: Metformin effects on ABCB1 expression and proliferation in pancreatic cancer cell lines with different ABCB1 genotypes/haplotypes
- Abstract 770: Gender differences in the expression of drug metabolizing enzymes in human liver tissues
Showing 5 of 8 shared publications
Li Pang
National Center for Toxicological Research
8 shared publications
In database
- Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers
- ATP-Binding Cassette Genes Genotype and Expression: A Potential Association with Pancreatic Cancer Development and Chemoresistance?
- Abstract 4428: Metformin effects on ABCB1 expression and proliferation in pancreatic cancer cell lines with different ABCB1 genotypes/haplotypes
- Abstract 759: ATP-binding cassette (ABC) genes genotype and expression: A potential association with pancreatic cancer development and chemoresistance
- Abstract A44: Individual variation in hENT expression in normal and malignant pancreatic tissues: The role of dietary agents in enhancing efficacy in gemcitabine treatment.
Showing 5 of 8 shared publications
Lascelles E. Lyn‐Cook
National Center for Toxicological Research
8 shared publications
In database
- Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells
- Cigarette Smoke Condensate Induces Differential Expression and Promoter Methylation Profiles of Critical Genes Involved in Lung Cancer in NL-20 Lung Cells In Vitro
- Effect of cigarette smoke condensate on gene promoter methylation in human lung cells
- In vitro analysis of factors influencingCYP1A2expression as potential determinants of interindividual variation
- Cigarette smoke condensate and individual constituents modulate DNA methyltransferase expression in human liver cells
Showing 5 of 8 shared publications
Hong‐Gang Wang
National Center for Toxicological Research (US)
6 shared publications
- Cigarette Smoke Condensate Induces Differential Expression and Promoter Methylation Profiles of Critical Genes Involved in Lung Cancer in NL-20 Lung Cells In Vitro
- ATP-Binding Cassette Genes Genotype and Expression: A Potential Association with Pancreatic Cancer Development and Chemoresistance?
- Cytotoxicity of Chronic Exposure to 4 Cigarette Smoke Condensates in 2 Cell Lines
- Abstract A44: Individual variation in hENT expression in normal and malignant pancreatic tissues: The role of dietary agents in enhancing efficacy in gemcitabine treatment.
- Abstract B15: Expression of ABC transporters in human pancreatic cancer cell lines and correlation with gemcitabine sensitivity.
Showing 5 of 6 shared publications
Athena Starlard‐Davenport
National Center for Toxicological Research (US)
5 shared publications
- Age and gender affect DNMT3a and DNMT3b expression in human liver
- Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach
- Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells
- Abstract 5601: The role of UDP-Glucuronosyltransferases in human breast cancers
- Abstract 4120: UDP-Glucuronosyltransferase 1 (UGT1A1) down-regulation correlates to menopausal status and stage of disease in human breast cancer tissues
Marta Pogribna
National Center for Toxicological Research
5 shared publications
In database
- Effect of titanium dioxide nanoparticles on DNA methylation in multiple human cell lines
- In vitro analysis of factors influencingCYP1A2expression as potential determinants of interindividual variation
- Effect of titanium dioxide nanoparticles on histone modifications and histone modifying enzymes expression in human cell lines
- Exposure to a Titanium Dioxide Product Alters DNA Methylation in Human Cells
- Exposure to a Titanium Dioxide Product Alters MicroRNA Expression in Human Cells
Kenneth L. Wiley
National Center for Toxicological Research (US)
4 shared publications
- Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: Ethnic differences and potential new targets for therapeutic drugs
- Ethnic Differences in DNA Methyltransferases Expression in Patients with Systemic Lupus Erythematosus
- Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149G/T
- Abstract 1530: Modulation of drug transporter expression in pancreatic cancer cells by indole-3-carbinol and gemcitabine: Potential transporter-targeted therapy
Edward L. Treadwell
East Carolina University (US)
4 shared publications
- Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: Ethnic differences and potential new targets for therapeutic drugs
- Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: Identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI
- Ethnic Differences in DNA Methyltransferases Expression in Patients with Systemic Lupus Erythematosus
- Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149G/T
Ebony Cotton
National Center for Toxicological Research
4 shared publications
In database
- Modulation of Estrogen α and Progesterone Receptors in Triple Negative Breast Cancer Cell Lines: The Effects of Vorinostat and Indole-3-Carbinol In Vitro
- Abstract PO-218: Molecular profiling of basal 2 subtypes of triple negative breast cancer cells and their response to a histone deacetylase inhibitor
- Abstract B125: Molecular profiling basal 2 subtypes of triple-negative breast cancer cells and their response to histone deacetylase inhibitor
- Abstract 5196: Vorinostat exhibits anticancer effects through modulation of nuclear receptors and tumor suppressor genes in sub-types of triple negative breast cancer cells
Yongmei Xiao
National Center for Toxicological Research (US)
3 shared publications
- Age and gender affect DNMT3a and DNMT3b expression in human liver
- Transcriptional activity of DNMT3B in pancreatic cancer cells: Effects of −149 (C→T) promoter polymorphism
- Cigarette smoke condensate and individual constituents modulate DNA methyltransferase expression in human liver cells
Rhonda J. Moore
China Tobacco (CN)
3 shared publications
- Modulation of Estrogen α and Progesterone Receptors in Triple Negative Breast Cancer Cell Lines: The Effects of Vorinostat and Indole-3-Carbinol In Vitro
- Abstract 18: Vorinostat reexpressed estrogen receptor (ER) in triple negative breast cancer cell line subtypes and sensitized cells to tamoxifen and indole-3-carbinol in vitro
- Abstract C109: Modulation of HDAC activity in subtypes of triple-negative breast cancer: Effects of vorinostat on HDAC 7 expression and cancer stem cells progression
Fatemeh Nouri Emamzaden
National Center for Toxicological Research
3 shared publications
In database
- Abstract 1631: Anti-cancer effects of vorinostat on 3D cultured pancreatic cancer cells
- Abstract 6251: High expression level of GSK3β in basal triple negative breast cancer: Effects of the HDAC inhibitor, vorinostat
- Abstract 4253: High expression of specific gene profiles in organoids from African American pancreatic cancer tumors
Tamara Nicolson
2 shared publications
- Expression of drug transporters in human kidney: impact of sex, age, and ethnicity
- Abstract 770: Gender differences in the expression of drug metabolizing enzymes in human liver tissues
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