Li Pang Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

22 h-index 86 pubs 2,500 cited

Research Areas

Pharmacological Effects and Toxicity Studies Cardiovascular Function and Risk Factors Mitochondrial Function and Pathology Nanoparticles: synthesis and applications Drug-Induced Hepatotoxicity and Protection Molecular Biology Techniques and Applications Cancer Treatment and Pharmacology

Links

ORCID Research Group

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OverviewAI-generated summary

Li Pang's research focuses on investigating the mechanisms of toxicity and developing methods for assessing drug safety, particularly in the areas of cardiovascular and hepatic health. Recent work includes studies on the use of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for evaluating drug-induced cardiotoxicity, including proof-of-concept studies with doxorubicin. Pang has also investigated the effects of preparation methods on delayed repolarization evaluations using iPSC-CMs and explored the impairment of liver mitochondrial functions by pexidartinib in primary human hepatocytes.

Further research extends to the development of novel drug delivery systems, such as cationic polymeric micellar structures with endosomal escape capabilities designed for enhanced intramuscular transfection of mRNA-lipid nanoparticles. Pang's work also encompasses the validation and use of New Approach Methodologies (NAMs) for toxicity screening and drug development. With a career marked by 86 publications and over 2,500 citations, Pang is recognized as a highly cited researcher. Key collaborators include William B. Mattes, Katy S Papineau, Lijun Ren, and Prathyusha Bagam, all from the National Center for Toxicological Research, with whom Pang has co-authored multiple publications.

Metrics

  • h-index: 22
  • Publications: 86
  • Citations: 2,500

Selected Publications

  • Validating and Using Cardiac NAMs for Toxicity Screening and Drug Development (2025) DOI
  • Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025) DOI
  • Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin (2024) DOI
  • New Alternative Methods in Drug Safety Assessment (2023) DOI
  • Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment (2022) DOI
  • Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs (2022) DOI

Collaborators

Researchers in the database who share publications

William B. Mattes National Center for Toxicological Research 3 shared publications Katy S Papineau National Center for Toxicological Research 2 shared publications Lijun Ren National Center for Toxicological Research 2 shared publications Prathyusha Bagam National Center for Toxicological Research 2 shared publications Laura K. Schnackenberg National Center for Toxicological Research 2 shared publications Vikrant Vijay National Center for Toxicological Research 1 shared publication Chengzhong Cai National Center for Toxicological Research 1 shared publication Minjun Chen National Center for Toxicological Research 1 shared publication

Similar Researchers

Based on overlapping research topics

Katy S Papineau National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Cardiovascular Function and Risk Factors Mitochondrial Function and Pathology
Strong match 5 shared topics
Laura K. Schnackenberg National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology Drug-Induced Hepatotoxicity and Protection
Good match 5 shared topics
J.C. Hsu University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies Cardiovascular Function and Risk Factors Drug-Induced Hepatotoxicity and Protection
Good match 4 shared topics
Prathyusha Bagam National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Cardiovascular Function and Risk Factors Molecular Biology Techniques and Applications
Good match 4 shared topics
Carrie L. Moland National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Cardiovascular Function and Risk Factors Molecular Biology Techniques and Applications
Good match 4 shared topics
Samaneh Goorani University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies Cardiovascular Function and Risk Factors Nanoparticles: synthesis and applications
Good match 4 shared topics