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Current · Arkansas
Last published
2026
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OpenAlex · ORCID
Refreshed
2026-10-08
S
Steven W. Barger
Federal Grant PI
High Impact
Professor
Also affiliated: United States Department of Veterans Affairs (2003–2006); University of Kentucky (1993–1996); University of Colorado Boulder (1998); Vanderbilt University (1989–1992); Veterans Health Administration (1998–2003); Central Arkansas Veterans Healthcare System (1998–2026); Geriatric Research Education and Clinical Center (1998–2000); National Institute on Aging (1996); John L. McClellan Memorial Veterans Hospital (1997–2016); University of Toledo (2014)
49 h-index
138 pubs
10,207 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Steven W. Barger, a professor at the University of Arkansas for Medical Sciences, has focused his research on the cellular and molecular mechanisms underlying neurological disorders, particularly Alzheimer's disease. His work investigates the role of various factors, including amyloid precursor protein metabolites, glucose transport, and inflammatory mediators, in neuronal dysfunction and death. Barger has received significant federal funding from the NIH/National Institute on Aging for two grants totaling over $750,000. These grants support his investigations into the role of glucose transport in Alzheimer's pathogenesis and the compromised function of glial glucose transporters in aging and the disease.
His research has explored the protective effects of tumor necrosis factors against amyloid beta-peptide toxicity and the involvement of specific signaling pathways, such as p38-MAPK, in mediating the pathological effects of microglia on neurons. Barger's publications also address the influence of beta-amyloid precursor protein metabolites on neuronal calcium homeostasis and the modulation of neuronal activity by secreted beta-amyloid-precursor protein. He has collaborated with several researchers at the University of Arkansas for Medical Sciences, including Joseph Asante, Robert J. Shmookler Reis, W. Sue T. Griffin, and Srinivas Ayyadevara.
With an h-index of 50 and over 10,000 citations across 139 publications, Barger is recognized as a highly cited researcher. His work contributes to the broader understanding of neurodegenerative diseases and potential therapeutic targets.
Metrics
- h-index: 49
- Publications: 138
- Citations: 10,207
Positions
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Research Health Scientist 1996–presentCentral Arkansas Veterans Healthcare System Geriatric Research, Education & Clinical Center ORCID
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Professor 1995–presentUniversity of Arkansas for Medical Sciences Geriatrics; Neuroscience Institutional directory
Selected Publications
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Insulin Growth Factor 1 affects glutamate receptor activity differently in primary cultures of neocortical versus hippocampal neurons (2026)
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Impact of P-glycoprotein substrates on transendothelial transport of amyloid-β peptide in an in vitro model (2026)
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Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, and secreted amyloid precursor protein: a common point of impact in Alzheimer’s disease pathogenesis (2026)
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Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation (2026)
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Impact of P-Glycoprotein Substrates on Transendothelial Transport of Amyloid-β Peptide (2025)
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Prescription-based association of P-glycoprotein substrates with Alzheimer's disease risk: A nested case-control study (2025)
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P-glycoprotein and Alzheimer’s Disease: Threats and Opportunities (2025)
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Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules (2024)
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Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity (2023)
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Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan (2023)
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Central repeat fragment of reelin leads to active reelin intracellular signaling and rescues cognitive deficits in a mouse model of reelin deficiency (2023)
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Design, synthesis, and characterization of novel Xc- transport inhibitors: Inhibition of microglial glutamate release and neurotoxicity (2023)
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Amyloid β-Peptide Effects on Glucose Regulation Are Dependent on Apolipoprotein E Genotype (2023)
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Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis (2022)
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Glucose transport in the regulation of T-cell activation: the journey may be as important as the destination (2022)
Federal Grants 2 $754,900 total
NIH
Contact PI
Apr 2023 - Mar 2028
Role of glucose transport in Alzheimer's disease pathogenesis
NIH
Contact PI
Apr 2021 - Dec 2026
Compromised function of a glial glucose transporter in aging and Alzheimer's disease
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Molecular aspects of endocrine and metabolic dysregulation in neurodegeneration NIH/NIA
- Neuroscience Research Center Core Facility at UAMS NIH
- Secreted Alzheimer amyloid precursor protein (sAPP) antagonizes Reelin receptors NIH
- CYCLIC GMP AND KB-DEPENDENT TRANSCRIPTION IN NEURONS NIH
- TO ESTABLISH UAMS ACCOUNT FOR SALARY SUPPORT OF XIANRONG MAO. INVOICE U OF A FOUNDATION OFFICE University of Arkansas Foundation
- Destablization of LRP family receptors by Alzheimer-related presenilin mutations NIH
- PPG Core C: Molecular Analysis NIH/NIA
- Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases - Continuation - Continuation NIH/Nat. Inst. on Aging
- Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences
- BALANCED BIOACTIVITY OF ALZHEIMER BETA AMYLOID PRECURSOR NIH
- Sp1, kappa-B enhancers and transcriptions in neurons NIH
- CYCLIC GMP--MEDIATOR OF BETA-AMYLOID PRECURSOR FUNCTION NIH
- Early Events in Alzheimer Pathogenesis NIH
Collaboration Network
Top Collaborators
W. Sue T. Griffin
University of Arkansas Medical Center
12 shared publications
In database
- Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway
- Interleukin-1 mediates Alzheimer and Lewy body pathologies
- Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide.
- Vitamin E suppression of microglial activation is neuroprotective
- S100β Induction of the Proinflammatory Cytokine Interleukin‐6 in Neurons
Showing 5 of 12 shared publications
A. Moerman
University of Arkansas for Medical Sciences
12 shared publications
In database
- Unique aspects of transcriptional regulation in neurons - nuances in NFkappaB and Sp1-related factors
- Characterization of a neuronal κB-binding factor distinct from NF-κB
- Differential Transcriptional Control of the Superoxide Dismutase-2 κB Element in Neurons and Astrocytes
- Molecular Mechanisms of Cytokine-Induced Neuroprotection: NFκB and Neuroplasticity
- Neuronal κB-binding Factors Consist of Sp1-related Proteins
Showing 5 of 12 shared publications
Shengzhou Wu
Wenzhou Medical University (CN)
9 shared publications
- Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide.
- Induction of Serine Racemase by Inflammatory Stimuli Is Dependent on AP‐1
- Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy
- Schwann cells exhibit excitotoxicity consistent with release of NMDA receptor agonists
- Reductions of the components of the calreticulin/calnexin quality‐control system by proteasome inhibitors and their relevance in a rodent model of Parkinson's disease
Showing 5 of 9 shared publications
Xianrong Mao
University of Arkansas for Medical Sciences (US)
9 shared publications
- Neuroprotection by dehydroepiandrosteronesulfate
- Unique aspects of transcriptional regulation in neurons - nuances in NFkappaB and Sp1-related factors
- NFκB in neurons? The Uncertainty Principle in neurobiology
- Glutamate receptor activation evokes calpain‐mediated degradation of Sp3 and Sp4, the prominent Sp‐family transcription factors in neurons
- Characterization of a neuronal κB-binding factor distinct from NF-κB
Showing 5 of 9 shared publications
Robert E. Mrak
University of Toledo (US)
7 shared publications
- Interleukin-1 mediates Alzheimer and Lewy body pathologies
- Vitamin E suppression of microglial activation is neuroprotective
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- S100β Increases Levels of β‐Amyloid Precursor Protein and Its Encoding mRNA in Rat Neuronal Cultures
- Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
Showing 5 of 7 shared publications
Meenakshisundaram Balasubramaniam
University of Arkansas Medical Center
7 shared publications
In database
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
Showing 5 of 7 shared publications
Yuekui Li
6 shared publications
- Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway
- Interleukin-1 mediates Alzheimer and Lewy body pathologies
- Vitamin E suppression of microglial activation is neuroprotective
- S100β Increases Levels of β‐Amyloid Precursor Protein and Its Encoding mRNA in Rat Neuronal Cultures
- S100B‐induced microglial and neuronal IL‐1 expression is mediated by cell type‐specific transcription factors
Showing 5 of 6 shared publications
Srinivas Ayyadevara
Central Arkansas Veterans Healthcare System
6 shared publications
In database
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Showing 5 of 6 shared publications
Robert J. Shmookler Reis
Central Arkansas Veterans Healthcare System
6 shared publications
In database
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
- Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules
- Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan
Showing 5 of 6 shared publications
John Roder
Mount Sinai Hospital (CA)
4 shared publications
- Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
- Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice
- Genetic loss of D‐amino acid oxidase activity reverses schizophrenia‐like phenotypes in mice
- Paradoxical roles of serine racemase and d ‐serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis
Mark P. Mattson
University of Kentucky (US)
4 shared publications
- Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease
- Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor
- Isoform‐Specific Modulation by Apolipoprotein E of the Activities of Secreted β‐Amyloid Precursor Protein
- Silencing survival data
Ling Liu
University of Arkansas for Medical Sciences
4 shared publications
In database
- Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway
- S100β Induction of the Proinflammatory Cytokine Interleukin‐6 in Neurons
- S100B‐induced microglial and neuronal IL‐1 expression is mediated by cell type‐specific transcription factors
- Microglial activation by uptake of fDNA via a scavenger receptor
Ling Liu
University of Arkansas for Medical Sciences (US)
4 shared publications
- S100β Increases Levels of β‐Amyloid Precursor Protein and Its Encoding mRNA in Rat Neuronal Cultures
- Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
- Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
- A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease
Richard A. Jones
Central Arkansas Veterans Healthcare System (US)
4 shared publications
- Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs
- S100β Increases Levels of β‐Amyloid Precursor Protein and Its Encoding mRNA in Rat Neuronal Cultures
- Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
- Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
Wei Wang
University of Arkansas for Medical Sciences (US)
4 shared publications
- Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
- Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice
- Roles of quaternary structure and cysteine residues in the activity of human serine racemase
- Cross‐linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species
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